Selection of Leads for Preclinical Investigation Sample Clauses

Selection of Leads for Preclinical Investigation. For each Validated Target, Allergan shall select and the Research Management Committee shall approve and prioritize up to *********** Active Compounds with activity against such Validated Target that are most promising for preclinical investigation by Allergan. At the time of such approval of selected compounds, such compounds shall be designated as "Collaboration Compounds," provided that such compounds are not Excluded Compounds. From time to time thereafter Allergan may designate additional Active Compounds as Collaboration Compounds, or remove such designation from previously designated Active Compounds, so long as the total number of such Collaboration Compounds with respect to a particular Validated Target shall not exceed *********** at any time. At the request of the Research Management Committee, pursuant to the Research Plan, CNSI shall conduct medicinal chemistry to optimize lead compounds. Allergan shall use reasonable efforts to conduct, at its expense, all preclinical testing and investigations necessary for Allergan to select appropriate Collaboration Compounds as Development Compounds for further development. Such further development may include, at Allergan's reasonable discretion, GLP Tox studies, formulation and process development, animal testing and other preclinical pharmaceutical development necessary to prepare and file an IND. CNSI will be responsible for providing the supply of all Active Compounds and Collaboration Compounds necessary to screen such compounds for preclinical development under Sections 5.2 and 5.3, prior to designation as a Development Compound but not more than *********. If more material is required, the Research Management Committee shall determine the process to obtain such material and such additional material will be obtained at Allergan's expense. Allergan shall provide promptly to the Research Management Committee the results of all work it performs pursuant to this Section 5.
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Related to Selection of Leads for Preclinical Investigation

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