Specific Aims. Under this contract, Principal Investigator shall conduct research as outlined in the specific aims of the application submitted titled: “Insert Project Title” and on file in the AASM Foundation’s National Office. Principal Investigator will use its reasonable best efforts to conduct this research in accordance with generally accepted scientific and professional standards.
Specific Aims. “State concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the results of the proposed research will exert” on the field of HIV/AIDS research.1 In the context of this application, you may wish to: Identify the relevant gap in knowledge and rationale for the research Highlight the objective of the proposal Describe the hypothesis to be tested and expected outcome State how the successful completion of this project will impact the field This section is typically about a half-page in length.
Specific Aims. To test the peptide (MS-1)-guided drug delivery system for its relative efficacy against relapsing disease in SJL mice compared with that of drug delivery via plain liposomes or as unpackaged (free) drug. In addition, to monitor various pparameters of systemic toxicity (e.g., toxicity to the liver, kidney, heart, and muscle) in experimental and control groups, and compare the efficacy versus safety profiles of the drug administered via 3 different modalities. Aim 2- To define the cell types within CNS (e.g., neurons, astrocytes, glial cells, endothelial cells) that are targeted by peptide MS-1 and MS-1-displaying liposomes. This is important for knowing how and where drug-carrying liposomes interact with the CNS tissue cells.
Specific Aims. To identify why women are dying from pregnancy-related factors using two data separate sources (CARE and MOHS). • To assess the capabilities of the service providers and determine the use of the service providers related to cost, socio-cultural barriers, distance and accessibility (4 delays). • To assess the reliability of the community-based MDR method.
Specific Aims. The overall focus research project is the development of novel, proprietary derivatives of cordycepin exhibiting enhanced stability towards ADA while retaining the parent compound’s biological activity. We will also attempt to expand our knowledge of the SAR of the benzamide compounds of interest to OXiGENE, while concurrently attempting to develop optimized compounds with either the ability to induce apoptosis or to inhibit NFkB. These goals will be accomplished through the following specific aims:
Specific Aims. 1. To identify factors that women cite as the reasons why they do or do not receive routine mammography screening,
2. To understand how insurance status influences mammography use.
Specific Aims. The main objective of the work that will be supported by this supplemental funding is to expedite availability of ESS by performance of a limited study (8-10 subjects) under an Investigational Device Exemption (IDE) protocol, with ESS generated by the commercial manufacturer, Lonza Walkersville, Inc (LWI). ESS remains an investigative device which has been studied previously as described above. Toward these objectives, two specific aims are proposed:
Specific Aims. To obtain the crystal structure of FGF4 bound to its highest affinity receptor, FGFR2.
Specific Aims. The overall goal of this research is to develop biochemical systems that will be optimal for assessment of ddrug affinity and selectivity for P2U-R. The specific aims are:
1. To develop a radioligand binding assay for P2U-R. A baculovirus expression vectors will be constructed with the human P2U-R cDNA, and P2U-R will be expressed to high levels in Sf9 insect cells in the absence and presence of G- protein subunits. We will synthesize [35S]UTPyS and use this high affinity P2U- R agonist as a radioligand to label the P2U-R membranes prepared from Sf9 cells overexpressing the receptor.
2. To stably express the human P2u-purinergic receptor. We will continue our characterization of the stably expressed P2U-R as a test for agonists and antagonists of this receptor.
Specific Aims. The Specific Aims of this Project are to characterize and identify the enzymes on the surfaces of human airway epithelial cells that metabolize extracellular 5' triphosphate nucleotides and characterize their metabolic products.
