Lead Compound Criteria definition

Lead Compound Criteria means (i) those criteria set forth in Exhibit 1.13.2 hereto, and (ii) such other criteria that are approved by the JRC in accordance with Section 2.5.9(a) and agreed in writing by the Parties in order for such compound to be deemed a Lead Compound for purposes of Section 1.41. “Lead Compound” shall mean any Collaboration Compound that becomes a Lead Compound in accordance with Section 2.6.
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Lead Compound Criteria means (i) those criteria set forth in the Research Plan to be “Lead Compound Criteria,” and/or (ii) such other criteria as are approved by the JRC and agreed in writing by the parties. If the Parties agree to any such other criteria, then their writing shall clearly set forth whether such criteria are in addition to, or alternative to, such criteria set forth in the Research Plan as of the Effective Date.
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Lead Compound Criteria means data which demonstrate the following attributes of the compound: biological activity, potency and selectivity for the designated molecular target in appropriate in vitro functional assays.
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Examples of Lead Compound Criteria in a sentence

  • Disputes among the JRC or the Parties as to whether to change or add to the Hit Compound Criteria and/or the Lead Compound Criteria shall be non-justiciable, and the Hit Compound Criteria and the Lead Compound Criteria shall remain as they exist as of the Effective Date unless the Parties otherwise agree in writing.

  • Upon determination by the JRC that a Compound satisfies the Lead Compound Criteria, Biogen Idec will have the right to designate such Compound as a Lead Compound at any time during the Research Term.

  • From time to time during the Research Term, Biogen Idec may approve the designation of any Target Selective Compound within the Field as a Lead Compound for purposes of Section 1.41 by written notice to Sunesis, provided such Target Selective Compound meets the Lead Compound Criteria with respect to a Collaboration Target.

  • MCSC, MCAC, MW and the Stockholders have caused this Agreement to be duly executed and delivered under seal, by their respective authorized officers, on the date first above written.

  • The earlier of (i) designation of the first Lead Compound for such target by the JRC, or (ii) identification of the first Lead Compound to meet Lead Compound Criteria for such target.

  • In the event that for any given [***]* successfully achieves Lead Compound Criteria milestone [***]* Leads that will be selected by GSK for [***]* Target Compounds, [***]* * Indicates that certain information contained herein has been omitted and filed separately with the Securities and Exchange Commission.

  • A PCC is a Program Compound which satisfies the [*] Lead Criteria, the Viral Inhibitor Lead Criteria, the Lead Compound Criteria and which has been accepted for further pre-clinical or clinical development by the PDRC pursuant to the PDRC’s standards for designating PCCs (or any successor designation thereof).

  • Tree replacement shall be based on the below ratio for every non-exempt tree of 10” DBH or greater that is removed in excess of Section 3140 (G) or as required in Section 3115 (B).

  • Under each Research Plan, the Parties will seek to identify orally bioavailable PROTACs to a given Collaboration Target that satisfy the Lead Compound Criteria [**], with more specific criteria to be agreed in the Research Plan for each Collaboration Target.

  • Execution Version Exhibit B Lead Compound Criteria A Compound that: [***] CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”.


More Definitions of Lead Compound Criteria

Lead Compound Criteria means the criteria for a [**] Decision, as listed in Exhibit B.
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Lead Compound Criteria means [†].
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Lead Compound Criteria means, with respect to a Compound, the criteria to be agreed and established by the JSC for the Research Program, as may be updated and amended from time to time as deemed appropriate by the JSC.
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Lead Compound Criteria means (i) those criteria set forth in Exhibit 1.7.3 hereto, and/or (ii) such other criteria that are agreed in writing by the Parties, which are required to be demonstrated from the testing of a compound in order for such compound to be deemed a Lead Compound.
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Lead Compound Criteria means that set of criteria set forth in [***]* as of the Effective Date, as attached hereto and hereby incorporated by reference, and as may be further specified by a Program of Work under the Research Plan, for the purpose of determining the achievement of a Lead Compound with respect to a particular Collaboration Target.
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Related to Lead Compound Criteria

  • Lead Compound means any compound of lead other than galena which, when treated in the manner described below, yields to an aqueous solution of hydrochloric acid a quantity soluble lead compound exceeding, when calculated as lead monoxide, five percent of the dry weight of the portion taken analysis.

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Development Candidate means a Compound that meets the Development Candidate Criteria for the initiation of a Development Program for the treatment of CF, and which is the subject of a notice from Vertex to CFFT that Vertex intends to commence formal pre-clinical development of the Compound in the Field pursuant to the provisions of Section 3.1 hereof.

  • Collaboration Target means the Initial Collaboration Targets set forth on Exhibit F and any Additional Target or Substitute Target that is selected in accordance with Section 3.3 of this Agreement.

  • Product Candidate means any pharmaceutical product developed, manufactured and/or tested by or on behalf of the Company that has not received a Regulatory Authorization for commercial distribution other than in connection with pre-clinical or clinical trials.

  • ASAM criteria means admission, continued service, transfer, and discharge criteria for the treatment of substance use disorders as published by the American Society of Addiction Medicine (ASAM).

  • Licensed Compound means [***].

  • Back-Up Compound means, with reference to any particular Development Candidate or Drug Product Candidate, a Compound which (a) has the same principal mode of action (i.e., Potentiator or Corrector) as that Development Candidate or Drug Product Candidate; and (b) was among the group of Compounds, identified by VERTEX as potential additional lead molecules having the same principal mode of action, from which the Development Candidate was selected.

  • Selection Criteria means and includes all of the requirements, considerations,

  • Licensed Compounds means: (a) Research Program Active Compounds; (b) Novartis Active Compounds; (c) salts, hydrates, solvates, esters, metabolites, intermediates, stereoisomers and polymorphs of Research Program Active Compounds or Novartis Active Compounds; and (d) prodrugs of Research Program Active Compounds or Novartis Active Compounds (any of the foregoing, a “Licensed Compound”).

  • Evaluation Criteria means the criteria set out under the clause 27 (Evaluation Process) of this Part C, which includes the Qualifying Criteria, Functional Criteria and Price and Preferential Points Assessment.

  • Design Criteria Package means concise, performance-oriented drawings or specifications for a public construction project. The purpose of the Design Criteria Package is to furnish sufficient information to permit Design-Build Firms to prepare a bid or a response to the District’s Request for Proposals, or to permit the District to enter into a negotiated Design- Build Contract. The Design Criteria Package must specify performance- based criteria for the public construction project, including the legal description of the site, survey information concerning the site, interior space requirements, material quality standards, schematic layouts and conceptual design criteria of the project, cost or budget estimates, design and construction schedules, site development requirements, provisions for utilities, stormwater retention and disposal, and parking requirements applicable to the project. Design Criteria Packages shall require firms to submit information regarding the qualifications, availability, and past work of the firms, including the partners and members thereof.

  • Research Plan shall have the meaning set forth in Section 2.1.

  • Nomination Criteria means the criteria made up of the Over-Riding Nomination Criteria andthe Specific Nomination Factors, and is also referred to as “this Criteria”.

  • Exempt compound means the same as defined in Rule 2.

  • Clinical review criteria means the written screening procedures, decision abstracts, clinical protocols, and practice guidelines used by a health carrier to determine the necessity and appropriateness of health care services.

  • Collaboration Product means a pharmaceutical product containing or comprising Compound in any dosage form alone, or in combination with, one or more other pharmaceutically active ingredients, and any and all Improvements thereto.

  • Development Milestone is defined in Section 5.3.

  • Review Criteria has the meaning assigned to that term in Section 12.02(b)(i).

  • Over-Riding Nomination Criteria means the criteria set out in clause 4.2.

  • Development Milestone Event has the meaning set forth in Section 7.2.1.

  • Research Program has the meaning set forth in Section 3.1.

  • Compounds means any or all of the following chemicals, as the context requires:

  • hit means the existence of a match or matches established by the Central System by comparison between biometric […] data recorded in the computerised central database and those transmitted by a Member State with regard to a person, without prejudice to the requirement that Member States shall immediately check the results of the comparison pursuant to Article 26(4);

  • Phase I Clinical Study means a human clinical study of a product, the principal purpose of which is a preliminary determination of safety in healthy individuals or patients, as described in 21 C.F.R. 312.21(a).

  • Phase IIb Clinical Trial means a clinical trial of a Product on sufficient numbers of patients that is designed to provide a preliminary determination of safety and efficacy of such Product in the target patient population over a range of doses and dose regimens.