Reference dose definition

Reference dose means a designated toxicity value established in these rules for evaluating potential noncarcinogenic effects in humans resulting from exposure to a chemical(s) of concern. Reference doses are designated in Appendix A.

Reference dose or “RFD” means a benchmark dose, derived from the NOAEL or LOAEL for a hazardous substance by consistent application of uncertainty factors used to estimate acceptable daily intake doses and an additional modifying factor, which is based on professional judgment when considering all available data about a substance, expressed in units of milligrams per kilogram body weight per day. This includes chronic reference doses, subchronic reference doses, and developmental reference doses.

Reference dose or "RfD" means the estimate of the daily intake of a chemical over a lifetime that is not likely to result in any significant adverse health effects (including in sensitive subpopulations).

Examples of Reference dose in a sentence

• After unilateral damage, the remaining ATL can continue to support comprehension for strongly-instantiated high frequency concepts; thus small semantic impairments are easily overlooked on standard semantic tests (Bell & Giovagnoli, 2007; Rice, Caswell, Moore, Hoffman, & Lambon Ralph, 2018; Rice, Hoffman, & Lambon Ralph, 2015; Rogers et al., 2004; Schapiro, McClelland, Welbourne, Rogers, & Lambon Ralph, 2013).

• Reference dose" is a value representative of a daily exposure level for the human population, including sensitive subpopulations, that is not likely to cause an adverse non-cancer health effect during a specified period of time (for example, an acute, short-term, subchronic or chronic exposure period).

• The piezocone has a standard (ASTM D-3441) 10 cm2 60° conical tip and a 150 cm2 friction sleeve.

• U.S. Environmental Protection Agency, Reference dose for chronic oral exposure to perchlorate and perchlorate salts.

• Appendix A - Contaminant Screening Process‌ Screening value calculations Non-cancer Health Effects SV = [(MRL or RfD)*BW]/CR [31] SV = Screening value (mg/kg or ppm) MRL = Minimal risk level (mg/kg/day) RfD = Reference dose (mg/kg/day) BW = Mean body weight (kg)CR = Mean daily consumption rate (kg/day) BW (adult) = 70 kgGeneral population CR = 17.5 g/day Subsistence population CR = 142.4 g/day If maximum concentration is greater than screening value, further evaluation is required.

More Definitions of Reference dose

Reference dose means an estimate of a daily exposure level for the human population, including sensitive subpopulations, that is likely to be without an appreciable risk of deleterious effects during a lifetime.

Reference dose or “RfD” means an estimate of a daily exposure, in units of milligrams of chemical per kilogram of body weight per day (mg/kg/d), to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious effects during a portion of a lifetime (up to approximately seven years, subchronic) or for a lifetime (chronic).

Reference dose means an estimate of a daily exposure to the general human population that is likely to be without an appreciable risk of deleterious effects during a lifetime of exposure.

Reference dose means a toxicity value for evaluating potential non-carcinogenic effects in humans resulting from exposure to a chemical of concern.

Reference dose or "RfD" means an estimate of a dose for a given duration to the human population, including susceptible subgroups such as infants, that is likely to be without an appreciable risk of adverse effects during a lifetime. It is derived from a suitable dose level at which there are few or no statistically or biologically significant increases in the frequency or severity of an adverse effect between the dosed population and its associated control group. The RfD includes one or more divisors, applied to the suitable dose level, accounting for:

Reference dose or "RfD" means a conservative estimate of the daily intake of the human population, including sensitive subgroups, that is likely to be without appreciable risk of deleterious effect during a lifetime. The reference dose is expressed in units of milligrams per kilogram body weight per day.

Reference dose or "RfD" means an estimate of a daily exposure to the human population, including sensitive subpopulations, that is likely to be without appreciable risk or deleterious effects over a lifetime. The RfD is expressed in units of daily dose, mg/kg/day.