Aims of the thesis Sample Clauses

Aims of the thesis. ‌ The primary research objective was to compare the efficiency of two competing trial design options that address the problem of contamination and estimate efficacy. The comparison built on the work by Xxxxx-Xxxxx et al. (2007) by comparing similar design methods. The first option was cluster randomisation at the level at which contamination was expected (i.e. preventing any contamination) with an estimator of the effect of treatment receipt on outcome that accounted for clustered data. The second option was individual randomisation, acceptance that contamination would take place, measurement of treatment receipt for all participants, and use of a randomisation-based efficacy estimator of the effect of treatment on outcome within the subpopulation of compliers. I aimed to make the findings from the comparison of these design options accessible to those planning trials in the form of an online decision support tool. The secondary research objective was to summarise and develop randomisation-based estimators of efficacy in a randomised trial with contamination, where treatment receipt could be measured on a binary or continuous scale. Having collected individual treatment receipt data for participants in D6 as part of this research project, the second part of this objective was to apply these estimators to evaluate the efficacy of the D6 intervention. The tertiary research objective was to review the problems and solutions associated with contamination in mental health trials of complex interventions. The aims were to assess the processes driving contamination, the typical extent of the problem, what researchers do in order to mitigate it, and the quantity of contamination bias within trials that used both individual- and cluster-level randomisation.
Sample 1
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Aims of the thesis. Stratified medicine is the targeting of treatment to a person's specific characteristics. The overall aim of this thesis is to develop statistical methodology for the analysis of randomised clinical trial data, to better understand mechanisms underlying treatment effects as a platform for stratified medicine. The work is developed with the following methodological objectives: 1. To understand the novel use of threshold models in treatment effect modification to evaluate mechanism in time to recovery or remission trials; 2. To maximise the potential from multivariate data and growth curve models by development of an efficient estimator to generate a survival function for the time to reach a threshold; 3. To combine indices to explore multiple moderators using methods that maximise predictive power and provide individual treatment recommendations; 4. With an emphasis on causal mechanisms, I will consider extensions to threshold models using instrumental variable methodology. Throughout the thesis, the methodology developed will be applied to real clinical datasets (see Chapter 1 for full descriptions), serving to illustrate the clinical benefit and interpretation of results from the novel methodology. Stata programs are developed to implement the new methodological components. New and current methodology is assessed via simulated trial data using Monte Carlo simulations. By characterising mechanistic treatment processes the intention is to improve clinical understanding and progress the best approaches to apply the results in practice. The chapter will now move to formally introduce the methodological themes and current literature.
Sample 1

Related to Aims of the thesis

  • Steps of the Procedure A grievance regarding a dispute over contract interpretation shall be filed at the lowest step in the grievance procedure in which the City’s representative would have the authority to make a final and binding resolution of the grievance, provided, however, that a grievance may not be filed at a Step higher than Step 2, except by mutual agreement of the parties. In the event a grievance is filed at a Step in the grievance procedure which the City deems inappropriate, the City’s representative with whom the grievance was filed shall remand the grievance to the appropriate Step.

  • Emergency Situations If the condition is an emergency, this will be communicated to the Contractor with the request that corrections are to be accomplished immediately. The Contractor shall respond to the notice in emergency situations within twenty-four hours. If the Contractor fails to respond within this time limit, the Owner may correct the defect and charge the Contractor for the Work. If it is determined the complaint is not the responsibility of the Contractor, the Contractor shall be promptly paid for the cost of the corrective work. The Contractor shall give notice in writing to the Owner when corrections have been completed.

  • Grading systems of the institutions [It is recommended that receiving institutions provide the statistical distribution of grades according to the descriptions in the ECTS users’ guide7. A link to a webpage can be enough. The table will facilitate the interpretation of each grade awarded to students and will facilitate the credit transfer by the sending institution.]

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  • Details of the Processing The subject-matter of Processing of Personal Data by Data Processor is the performance of the Services pursuant to the Agreement. The duration of the Processing, the nature and purpose of the Processing, as well as the types of Personal Data Processed and categories of Data Subjects under this DPA are further specified in Schedule 1 (Details of the Processing) to this DPA.

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  • Mitigation Measures Company shall take commercially reasonable measures (except measures causing it to incur out-of-pocket expenses which BNYM does not agree in advance to reimburse) to mitigate losses or potential losses to BNYM, including taking verification, validation and reconciliation measures that are commercially reasonable or standard practice in the Company’s business.

  • Emergency Situation In the event of an emergency situation beyond our reasonable control, such as an "act of God," war, fire, or natural disaster, services involving your account could be available only in a modified or reduced form or could be entirely unavailable. Unless expressly prohibited by applicable law, you agree that we will have no liability to you for such modification, reduction, or unavailability of services caused by an emergency situation.

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