Cartridge. A customer replaceable module that holds toner or ink and that must be inserted into or connected to an imaging equipment Product for the imaging equipment Product during print. Ink and toner bottles or similar units designed to refill ink or toner tanks are not “Cartridges” for the purposes of this Voluntary Agreement.
Cartridge. Each cartridge consists of a printed circuit board (PCB) with an array of gold electrodes on one face of the PCB. Each electrode is approximately 0.5 mm in diameter. Each electrode is connected to a contact paid on one edge of the PCB via a thin interconnect strip of metal. The exposed area of each electrode is defined by one or more layers of solder mask (a photosensitive insulating layer). Each electrode is covered by the solder mask, except for a circle in its center of approximately 0.25 mm diameter. The solder mask completely covers the entire surface of the PCB except for the electrodes and the connector pads on one edge of the PCB. The electrodes of each PCB “chip” are modified with a self-assembled-monolayer (XXX) containing insulating molecules and DNA oligonucleotides (15-30 nucleotides in length). The insulating molecules are thio-alkyl or disulfide-alkyl compounds which have appended triethylene-glycol groups. The DNA oligonucleotides are modified (usually on the 3’ terminal nucleotide) with an thio-alkyl group. The electrodes are modified by applying a small droplet of the two components in an aqueous solution to each electrode using a non-contact automated spotter. Each electrode can be modified with a different oligonucleotide sequence or multiple electrodes can be modified with the same oligonucleotide. The cartridge is formed by attaching the modified PCB to a plastic housing. The plastic housing and a gasket define a fluid chamber over the electrode array. The plastic housing and gasket also form an inlet port to the cartridge designed to accept a standard disposable pipet tip for filling. The cartridges in an Assay Kit are enclosed in a metalized plastic pouch which is filled with nitrogen gas.
Cartridge. Each cartridge consists of a printed circuit board (PCB) with an array of 36 gold electrodes on one face of the PCB. The gold electrodes are formed by electroplating first tin and then gold over copper. Electrodes, interconnects and edge contacts are all coated with electroplated gold. The exposed area of each electrode is defined by two layers of solder mask. Each electrode is covered by a first layer of solder mask, except for a circle in its center of 0.25 mm diameter. The second (top) solder mask layer has a larger circular hole (approximately 1 mm in diameter) around each DNA electrode. Each PCB also has a single reference electrode which is gold, but coated with a Ag/AgCl paste. Each PCB also has a single auxiliary electrode which is a gold electrode of approximately 1 mm diameter. Each electrode is spotted with different capture probe, usually 20-25 nucleotides in length. Typically, two electrodes are coated with each capture probe to provide duplicate analysis for increased reliability of the assay. Two positive control electrodes are spotted with a capture probe which will hybridize with a synthetic DNA oligonuclotide which is included in the assay buffer. The assay buffer also contains a signal probe complementary to the synthetic oligonuclotide. Two negative control electrodes are also included and spotted with capture probes that have no significant complementarity to any signal probe or target polynucleotide. The cartridge is formed by attaching the modified PCB to a plastic housing. The plastic housing and a double sided adhesive gasket define a fluid chamber over the electrode array.
Cartridge. Each cartridge will consist of a printed circuit board (PCB) with an array of 75-100 gold electrodes on the PCB. A higher density edge connector configuration will be employed to allow the higher number of electrodes. The cartridges are designed to allow mixing of the fluid contained in the cartridge to facilitate hybridization kinetics. SCHEDULE 7 Royalty Reports Royalty reports are required from the Licensee and each Affiliate for each Calendar Quarter during the Term. Each report is to contain information that enables OGT to check the volume and the value of each form of Net Sales interaction as expressly allowed by the Agreement. Each report should contain the following sections
Cartridge. 4-1 Unit Price US$fully burdened cost plus 15%
