Disease Signatures and Personalised Medicine Sample Clauses

Disease Signatures and Personalised Medicine. Many challenges are raised by the interpretation of complex biological and clinical data to identify signatures that may be clinically useful in the diagnosis and treatment of mental disorders. Further challenges arise if such signatures are used to identify predispositions or susceptibilities to disorders. These challenges include the recognition and interpretation of statistical clusters within data, identifying when a particular biological signature is an indicator for a disease, translation of findings into protocols and guidelines for clinical practice, ensuring appropriate use of disease signatures by clinicians and patients, and preparing the regulatory and governance infrastructure for what is often termed ‘personalised’ or ‘precision’ medicine. Many of these can only adequately be addressed though strong consultation and engagement with affected communities. On the basis of our Foresight work on disease signatures, WP12.1 made a number of recommendations, intended to ensure that an effective partnership is created with patients, clinicians and other potential users of disease signatures. These focussed on the need to include patients and clinicians in a research advisory capacity; to address the implications of disease signatures in mental disorders for clinical practice and clinical ethics; to consider the clinical and ethical challenges arising when brain signatures are used in an attempt to identify pre-clinical susceptibility; the need for a communication strategy and a public engagement programme and - crucially - the engagement of other research communities and relevant regulators to develop appropriate pathways for translation of research to clinical applications. Some of these recommendations have already been incorporated into the developing structure and processes of the MIP, others will require action by others as the work of the Human Brain Project develops. Our report was widely disseminated within and beyond the HBP, and WP12.1 is working with other WPs within SP12, and with the other members of the HBP, to encourage implementation of the recommendations. These collaborations embody the principles of Responsible Research and Innovation, and aim to ensure that the work of the HBP is directed to meet the major challenges posed by psychiatric and neurological disorders to contemporary individuals, families, communities and societies.
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