Fluoride and the oral environment Sample Clauses

Fluoride and the oral environment. Effects on enamel When topical fluoride is present in the oral environment surrounding teeth (i.e. in saliva, plaque, crevicular fluid, oral soft tissues and directly on the enamel/dentine surface itself), there are two distinct post-eruptive effects on enamel. Low concentrations of ionic fluoride interact with enamel during the process of demineralisation to either modify the chemical and biologic characteristics of enamel apatite by forming fluorhydroxyapatite or calcium fluoride. The former is more likely to occur when the fluoride concentration is less than around 50 ppm and the environment is acidic. Formation of fluorhydroxyapatite occurs only in the outermost layers of enamel and forms an integral part of the tissue that will be lost if the tissue is worn away. Equation 1 Formation of fluorhydroxyapatite from hydroxyapatite in the presence of ionic fluoride Ca10(PO4)6(OH)2 + F− + H+ → Ca10(PO4)6(OH)F + H2O Under neutral conditions this is a slow process, however in a low pH solution the solubility of enamel increases considerably and fluorhydroxyapatite formation increases under such conditions. Ionic fluoride promotes conversion of brushite and octacalcium phosphate to apatite and promoting formation of fluorhydroxyapatite, in preference to brushite or β- tricalcium phosphate in acidic conditions (Ten Cate et al., 2008). At higher fluoride concentrations (>100 ppm) calcium fluoride is formed thus: Equation 2 Formation of calcium fluoride from hydroxyapatite in the presence of ionic fluoride Ca10(PO4)6(OH)2 + 20 F− + 8 H+ = 10 CaF2 + 6HPO42− + 2H2O Therefore the higher the concentration of fluoride and the more acidic the solution the more calcium fluoride is formed on the tooth surface. In the oral environment, calcium fluoride is also precipitated in plaque, in pellicle, in porosities and other plaque retention factors. Calcium fluoride is formed in the shape of spherical globules scattered across the tooth surface which can be seen using scanning electron microscopy as a round globule with a nodular surface around 0.6 µm in diameter (Xxxxxxx, 2000). Formation of calcium fluoride globules is the only surface event that is detectable using chemical means after application of high fluoride concentrations. Subsequently, after the calcium fluoride is worn away and all chemical traces have disappeared, a reduced caries incidence in the following months is noted (ten Cate and Xxxxxxxxxxxx, 1996).
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