Reader. 1. This Letter of Understanding covers individuals who are employed to perform work as a Reader. A job description for this position will be provided by OC.
Reader. The Reader is responsible for supporting the delivery of interpretive services to visually disabled staff, specifically:
Reader. Reader is a free software program available for many platforms that allows a user to view and print PDF documents.
Reader. This Agreement is for a lease of personal property and related software known as the ProCheck Antioxidant Reader (“Reader”) as more specifically described on the attached Exhibit A, which is incorporated herein by this reference.
Reader. The Generation 1 Reader is an instrument for performing hybridization and interrogation of multiple cartridges simultaneously, each in a separate compartment. The instrument is controlled by a central processing unit (CPU) which may be an off-the-shelf personal computer (Windows-based) or an internal, embedded computer. The CPU and associated electronic circuitry monitor and control the temperature of each compartment. The CPU and associated electronic circuitry also perform electrochemical analysis of each DNA electrode in the cartridges. Electrochemical analysis is performed using multiple potentiostat circuits, each of which analyzes a cartridge in one compartment at a time. The circuit measures the potential of the fluid in the cartridge using a reference electrode in the cartridge. It applies a voltage to the auxiliary electrode in the cartridge to achieve a desired voltage in the fluid. The desired voltage is a time variable waveform which is programmable, usually an alternating-current (ac) voltage added to a dc ramp. The current which flows from the auxiliary electrode to each DNA electrode (working electrode) in response to the applied voltage is measured by the circuitry as a function of time. The current is amplified and fed into a high speed, high precision analog to digital (A/D) converter. The digital information is stored in memory, as is the time for each data point. Each DNA electrode is analyzed sequentially in an identical manner. Signal processing for the data set corresponding to each DNA electrode is performed by determining the root-mean-square (RMS) current as a function of applied voltage to produce a standard ac voltammogram for each electrode. In addition, the data set may be analyzed by calculating the RMS current response for each DNA electrode at integer multiples of the fundamental frequency (harmonics) of the applied ac voltage. Waveform analysis is performed on the resultant waveform to characterize the DNA hybridization on the DNA electrode.
Reader. The Generation 1.0 Reader, called the eSensor™ 4800 Reader, incorporates 48 compartments for separate cartridges. It is controlled by a Windows XP-based personal computer and also contains embedded microprocessors for signal processing, thermal control, and electrochemical analysis. The personal computer communicates with the Reader by serial communication. The cartridge compartments are arranged in six columns of eight compartments. Each column can be independently controlled and can, thus, be used for different assays. The 4800 Reader contains eight independent potentiostats for electrochemical analysis so that all cartridges in a single column can be analyzed at once. Alternating current voltammetry (ACV) is performed by applying a linear dc ramp from -100 to +600 mV combined with an ac sine wave of approximately 100 mV amplitude and approximately 100 Hz. Signal processing for each DNA electrode is performed by the embedded microprocessors. The fourth harmonic ac voltammogram is determined and downloaded to the personal computer for waveform analysis. Waveform analysis is performed by analyzing the ac voltammogram, searching for the expected shape of the fourth harmonic waveform. For genotyping assays, each waveform is analyzed for the existence of two fourth harmonic waveforms, overlapping but having different electrochemical potentials.
Reader. The Generation 1.1 Reader will be modular in construction and will accommodate from eight to 48 cartridges, expandable in columns of eight compartments. The Reader will use an embedded computer and the electronics will be redesigned and use updated electronic components but will perform similar functions to the 4800 Reader. Each cartridge compartment will include actuators to allow mixing of fluid components within the cartridge.
Reader. The sales price for each Reader (which shall be contained in finished product packages which include operator's manual, retail cartons, carton packing material, languages on packages should be English and/or Japanese) purchased by KDK for commercial sale hereunder shall be equal to (a) [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] (FOB Munich Airport, Frankfurt Airport or Hamburg Seaport Incoterms 1990) per Reader for orders received by Biosite prior to the second anniversary of the First Commercial Sale of the Reader, and (b) [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] (FOB Munich Airport, Frankfurt Airport or Hamburg Seaport Incoterms 1990) per Reader for orders received by Biosite on or after the second anniversary and prior to the fourth anniversary of the First Commercial Sale of the Reader. The sales price for each Reader for orders received on or after such fourth anniversary shall be determined from time to time by the mutual agreement of the parties.
Reader. Prior to, and during the period of one (1) year following, the date the First Commercial Sale of the Reader in the Territory, Biosite shall sell and deliver to KDK such quantity of Readers, not to exceed [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION], as KDK requests solely for demonstration purposes in connection with the promotion, marketing, distribution and sale of the Reader, but not for commercial sale hereunder, at a price equal to [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] (FOB Munich Airport, Frankfurt Airport or Hamburg Seaport Incoterms 1990) per Reader. During the term of the Agreement, KDK may request from time to time any additional Readers for demonstration purposes and upon such request, the parties shall negotiate in good faith terms and conditions (including quantity and price terms).
Reader. The sales price for each Reader (which shall be contained in finished product packages which include operator's manual, retail cartons, carton packing material, languages on packages should be English and/or Japanese) purchased by KDK for commercial sale hereunder shall be equal to (a) [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] (FOB Munich Airport, Frankfurt Airport or Hamburg Seaport Incoterms 1990) per Reader for orders received by Biosite prior to the [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] of the First Commercial Sale of the Reader, and (b) [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] (FOB Munich Airport, Frankfurt Airport or Hamburg Seaport Incoterms 1990) per Reader for orders received by Biosite on or after the [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] and prior to the [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] of the First Commercial Sale of the Reader. The sales price for each Reader for orders received on or after such [CONFIDENTIAL MATERIAL REDACTED AND FILED SEPARATELY WITH THE COMMISSION] shall be determined from time to time by the mutual agreement of the parties.
