Statement (Scope) of Work. The Client desires to have the University undertake a scope of work under the research project entitled: The Scope of Work will be in accordance with Appendix A, entitled "Statement of Work and Budget." The University agrees to use reasonable effort to perform the research project described in Appendix A, hereafter referred to as "the Research."
Statement (Scope) of Work. A. General Description of the Required Objectives and Desired Results WSU is soliciting genotyping services in support of their service contract with the PRB of the NICHD. Ongoing research projects conducted by The PRB of the NICHD include studying the mechanisms of disease responsible for adverse pregnancy outcome and infant morbidity and mortality. Priority is given to the understanding of the factors that predispose to preterm birth, intrauterine growth retardation, preeclampsia, abruption and other conditions that are collectively referred to as the “Great Obstetrical Syndromes”. A body of evidence now indicates that several obstetrical syndromes are. clustered within families suggesting the presence of heritable risk factors. Moreover, recent evidence derived from DNA linkage studies indicates that a precise genetic locus is linked to pre-eclampsia. Genetic association studies of candidate genes also indicate that certain polymorphisms are associated with a predisposition for these complications and, in some cases, protection. Perinatal morbidity and mortality are largely determined by five major complications of pregnancy: preterm labor (PTL), preterm premature rupture of membranes (PROM), small for gestational age (SGA), pre-eclampsia and abruptio placenta. The perinatal consequences of these disorders along with congenital anomalies account for over 95% of infant mortality (death before the age of one). Although obstetrical complications have been recognized since antiquity, it is now apparent that they are not discrete disorders and are now collectively referred by the term “the great obstetrical syndromes”. The features of these syndromes are: 1) multiple etiologies; 2) chronicity; 3) the clinical manifestations (i.e., hypertension, PTL, rupture of membranes or reduced fetal growth) are adaptive in nature; 4) symptomatic treatment of the specific syndrome is ineffective in reducing perinatal morbidity; and 5) clinical presentation depends upon genetic (fetal and/or maternal) and environmental interactions. The research agenda of the PRB focuses in defining the mechanisms of diseases responsible for “the great obstetrical syndromes” with the goal of improving the pathophysiologic understanding of these disorders, developing methods for the prediction, early diagnosis, and interventions leading to the prevention of these conditions. These studies require high-throughput genotyping of large numbers of samples. Currently, WSU houses and supports the ...
Statement (Scope) of Work. A. The Berkley Group will provide services to Client once issued individual Work Orders for each task assigned constituting the Scope of Services (“Scope of Services”/”Services”) as set forth in this Agreement.
Statement (Scope) of Work. The Client desires to have the University provide the services (“Services”) described in the Scope of Work attached hereto and incorporated herein as Appendix A. The University agrees to use reasonable efforts to perform the Services as described in Appendix A in connection with the Client’s research project, hereafter referred to as the “Project." The Client acknowledges, understands and agrees that the University makes no express or implied warranties for results of the Services, nor their reliability and/or impact on or utility for the Project.
