Vertebral fracture Sample Clauses

Vertebral fracture. Vertebral fractures affect approximately 20% of postmenopausal women [157, 158] and are the most common complication of OP. Vertebral fractures are associated with significant pain, morbidity, excess mortality and health and social service expenditure resulting from long-term disability There is also an increased risk of further fractures in patients who have already sustained fractures [159, 160]. It is increasingly difficult to quantify the incidence of vertebral fracture as only a third of patients come to medical attention after fracture [161]. However, The European Prospective Osteoporosis Study (EPOS) assessed vertebral fracture incidence in 3174 men and 3614 women over a 3 year period and reported vertebral fracture incidence increases markedly with age in both men and women [162]. Vertebral fractures commonly occur in the upper lumbar or lower thoracic vertebrae [161] and if symptomatic, typically present with the sudden onset of severe pain [163], and there is often an associated loss of height and thoracic kyphosis. One of the most important factors impairing quality of life is back pain. The EVOS study [159] demonstrated that patients with three or more vertebral deformities were almost twice as likely to report back pain in the previous year, compared with subjects without deformity.
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