Changes in pharmacokinetics. Re- sults of pharmacokinetics measure- ments (i.e., biotransformation, extent of absorption, tissue distribution, and excretion) obtained in rats receiving the single low oral dose of test sub- stance (Group B) shall be compared to the corresponding results obtained in rats receiving repeated oral doses of test substance (Group F).
Changes in pharmacokinetics. R e- s u l t s of p h a r m a co k i n e t ics m e a s ur e- m e n t s ( i . e., bio a v a il a bili t y a n d ex t e n t of a bso r p t io n , t iss u e dis t r ib u t io n , a n d exc r e t io n) ob t a i n ed i n r a t s r eceivi n g t h e s i n gle low o r a l dose of t h e t es t s u b- s t a n ce ( G r o u ps B a n d C) s h a ll be co m - p a r ed t o t h e co rr espo n di n g r es u l t s ob- t a i n ed i n r a t s r eceivi n g r epe a t ed o r a l doses of t h e t es t s u bs t a n ce ( G r o u p F ).
