Imputation. AT&T shall impute to its costs of providing telecommunications services (and charge any affiliate, subsidiary, or associate company engaged in the provision of such services) an equal amount to the charges set forth in this Section for all of the Conduits, Ducts, and Poles it occupies and uses.
Imputation. BellSouth shall impute to its costs of providing telecommunications services (and charge any affiliate, subsidiary, or associate company engaged in the provision of such services) an equal amount to the charges set forth in this Section for all of the conduits, ducts, and poles it occupies and uses.
Imputation. All sums of money received by the Agent and the Secured Parties from the Borrower or from anyone whomsoever, which may be imputed in reduction of the Guaranteed Obligations, shall be considered as payments which the Agent and the Secured Parties may impute, subject to the provisions of the Transaction Documents, as they see fit, notwithstanding the provisions of Article 1572 of the Civil Code of Quebec as well as every other legal rule concerning the imputation of payments.
Imputation. The knowledge or actions or failure to act on the part of any fiduciary of the Company shall not be imputed to Indemnitee, Indemnitee’s Spouse or any Controlling Person for purposes of determining entitlement to indemnification under this Agreement.
Imputation. Toute somme pouvant être reçue par l’un ou l’autre des Créanciers et provenant de la réalisation ou de la liquidation d’actifs affectés par les Sûretés xxxxx être imputée ou distribuée selon l’ordre de collocation prévu à l’article 3.1 et de façon à xxxxxx effet aux dispositions de la présente convention.
Imputation. 4. Sous reserve de toute disposition specifique des presentes quant a l'affectation de toute somme particuliere, toutes sommes d'argent se trouvant entre les xxxxx xx fiduciaire a la suite de sa prise de possession, de son exploitation des affaires de la corporation, de toute vente et de toute liquidation des biens hypotheques ou autrement, seront imputees par le fiduciaire dans l'ordre suivant:
Imputation. BellSouth shall impute to its costs of providing telecommunications services (and charge any affiliate, subsidiary, or associate company engaged in the provision of such services) an equal amount to the charges set forth in this Attachment for all of the conduits, ducts, and poles it occupies and uses.
Imputation. Imputation is the function of the justice of God directed toward mankind and relates to the plan of God for mankind. Imputation functions as an act of condemnation or blessing from the integrity of God to mankind. Imputation is the action of the justice of God whereby either condemnation or blessing is assigned, ascribed, attributed or superimposed to another being. The believer advances in the plan of God with each imputation.
Imputation. The knowledge or actions or failure to act on the part of any person, including any fiduciary of the Company shall not be imputed to Indemnitee or Indemnitee’s Spouse for purposes of determining entitlement to indemnification under this Agreement.
Imputation. To expand the number of interrogated SNVs, imputation can be used for technologies that do not cover the entire genome (Table 2.2). Imputation is predominantly used in GWAS analysis and to expand the PGx panel in genome wide arrays [8]. With imputation, the presence of a genomic variant is inferred based on the absence or presence of a linked SNV. These predictions all come with a probability for the occurrence of the SNV of interest. Often only imputations with a high probability are included (e.g., >90%) to avoid inaccurate assignments. Xxxxxxxx et al. have shown that imputation accuracies as high as 99% can be reached for PGx variants [8]. Nevertheless, a probability of 90% also means that there is a 10% change that the imputed variant is not correct. While this is certainly acceptable for population studies, it is not sufficient for tailoring drug treatment in an individual patient. Furthermore, to reach high imputation accuracy, an imputation dataset specific to each patient’s ethnical background is needed as the level of linkage disequilibrium (LD) between two SNVs can differ between different populations [8,75]. One clear example of the differences in LD between populations is the HLA tagging SNVs; to identify the HLA-A*3101 allele, associated with carbamazepine toxicity, a linked SNV is used. In Caucasians, the rs1061235 (NC_000006.12:g.29945521A>T) variant is in full LD with the *3101 haplotype, therefore the presence of the HLA-A*3101 allele can be inferred based on the presence of the rs1061235 variant [76]. However, in the Asian population, this variant is not in LD with the *3101 allele. For individuals of Asian descent, the rs1633021 (NC_000006.12:g.29779092T>C) variant can be used as a linked SNV as this variant is in LD with HLA-A*3101 in this population [77]. Using the Caucasian-linked SNV in the wrong population can lead to errors in the inferred haplotype, phenotype and ultimately lead to treatment errors. Therefore, the application of imputation should be limited to research purposes until the reliability for an individual patient has been proven.
