Naming of organoids Sample Clauses

Naming of organoids. An organoid does not have the same properties and functions as an organ. It is therefore incorrect to refer to organoids as mini-organs, and communicating incorrect information constitutes misconduct. Misnaming is both prejudicial for the advancement of science and for the trust of the public. The HYBRIDA project recognizes the effort of the scientific community to raise a consensus for an adequate nomenclature for nervous system organoids and assembloids. We endorse the recently proposed nomenclature consensus for nervous system organoids and assembloids73 . These authors proposed a simple set of guidelines for naming that is rooted in developmental neuroanatomy. We anticipate that this effort will facilitate communication and scientific advancement, promote collaborations, and initiate the development of quality control measures and benchmarking in the field. Three main classes of 3D models are used in the field at present: organoids, assembloids and grafted organoids. As we do in the HYBRIDA project, authors define organoids as in vitro- generated cellular systems that emerge by self-organization, include multiple cell types, and exhibit some cytoarchitectural and functional features reminiscent of an organ or organ region. Concerning nervous system organoids, they may be constructed from pluripotent stem cells but can also be derived from donor tissues with growth potential (such as glioblastoma organoids). They can be generated as 3D cultures or by a combination of 3D and 2D approaches (also known as 2.5D) that can develop and mature over long periods of time (months to years). Engineered 3D cultures obtained by bioprinting that enable and/or sustain self-organization would also be considered as organoids. Authors refer to nervous system organoids by the major anatomic region they model, such as cortical organoids, retinal organoids, hypothalamic organoids or spinal cord organoids. The terms neural organoids and nervous system organoids each encompass a broader spectrum of cell types, including those from the central and the peripheral, autonomic and enteric nervous systems, and are appropriate as blanket terms or to describe organoids encompassing several regionally diverse cell types. These authors define assembloids as self-organizing cellular systems resulting from the combination of a type of organoids with another type of organoids (for example, dorsal forebrain with ventral forebrain) or with different specialized cell types (for example, corti...
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