Preliminary Fact. Grant Agreement no. • The identification of groups of patients with similar characteristics will be investigated based upon classification and clustering analysis (e.g.random forests and supporing vector machines, hierarchical clustering, k-means,).
Preliminary Fact. Grant Agreement no. Figure A4 Graphical representation of the correlation matrix between the QLQ-C30, QLQ-BR23, WHQ, FACIT and BDI scores at month 12 from baseline. Positive correlations are displayed in blue and negative correlations in red colour. The colour intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: the pairwise deletion method was applied. The scales with the highest number of missing data were the B23 upset by hair loss, the B23 sexual enjoyment and the WQH sexual behaviour. For the correlation analyses between variable pairs including these scales, the number of complete cases ranged from 190 to 284. In all other variable pairs, the complete cases ranged from 395 to 468.
Preliminary Fact. Grant Agreement no. Figure A5 Graphical representation of the correlation matrix between the QLQ-C30, QLQ-BR23, WHQ, FACIT and BDI scores at month 18 from baseline. Positive correlations are displayed in blue and negative correlations in red colour. The colour intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: the pairwise deletion method was applied. The scales with the highest number of missing data were the B23 upset by hair loss, the B23 enjoyment and the WQH sexual behaviour. For the correlation analyses between variable pairs including these scales, the number of complete cases ranged from 199 to 275. In all other variable pairs, the complete cases ranged from 366 to 434. D4.1 Preliminary Fact Grant Agreement no. Figure A6 Graphical representation of the correlation matrix between the QLQ-C30, QLQ-BR23, WHQ, FACIT and BDI scores at month 24 from baseline. Positive correlations are displayed in blue and negative correlations in red colour. The colour intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: the pairwise deletion method was applied. The scales with the highest number of missing data were the B23 upset by hair loss, the B23 sexual enjoyment and the WQH sexual behaviour. For the correlation analyses between variable pairs including these scales, the number of complete cases ranged from 193 to 321. In all other variable pairs, the complete cases ranged from 363 to 433. D4.1 Preliminary Fact Grant Agreement no. Figure A7 Graphical representation of the correlation matrix between the QLQ-C30, QLQ-BR23, WHQ, FACIT and BDI scores at month 30 from baseline. Positive correlations are displayed in blue and negative correlations in red colour. The colour intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: the pairwise deletion method was applied. The scales with the highest number of missing data were the B23 sexual enjoyment and the WQH sexual behaviour. For the correlation analyses between variable pairs including these scales, the number of complete cases ranged from 185 to 232. In all other variable pairs, the complete cases ranged from 305 to 404. D4.1 Preliminary Fact Grant Agreement...
Preliminary Fact. Grant Agreement no. investigated in the BOUNCE project: breast cancer women. First of all, retrospective data research is important to design the next study more accurately, thus allowing the maximization of the chances of actually predicting resilience. Moreover, it is harmless to patients, as it makes use of material that exists already and does not require further procedures to patients.
Preliminary Fact. Grant Agreement no. The RSA is a self-report scale for measuring protective resilience factors (intrapersonal and interpersonal) that promote the adaptation of adversity. The resilience factors are divided into 6 subscales: Perception of self. Planned future. Social competence, Structured style. Family cohesion and Social resources. State Trait Anxiety Inventory (STAI) (Xxxxxxxxxxx et al., 1983) It is a 40 item questionnaire that assesses trait and state anxiety. It is used in clinical settings to diagnose anxiety and to discriminate between anxiety as a symptom and anxiety as a habitual way of responding to external stimuli. D4.1 Preliminary Fact Grant Agreement no. 5[A]. Preliminary Correlation Analyses using the Retrospective BOUNCE Data [Code Letter: A] A1 Preliminary Correlation Analysis with Retrospective data: The HUS Dataset
Preliminary Fact. Grant Agreement no.
Preliminary Fact. Grant Agreement no. The C30 Cognitive functioning scale correlates strongly with WHQ memory scale (r 0.61 – 0.69), FACIT-F fatigue scale (r 0.57 – 0.65) and BDI depression scale (|r|0.54 – 0.63). The C30 Physical functioning scale has the strongest correlation with both FACIT-F and C30 fatigue scales (|r| 0.6). A strong correlation is noted between C30 role functioning with fatigue scales (FACIT-F and C30) (|r| 0.57). Depression correlates substantially with WHQ anxiety and sleep scales and C30 insomnia (|r| 0.5 – 0.6). Fatigue (FACIT F and to a lesser extend C30) exhibits a substantial correlation with all functioning scales of C30 questionnaire, as well as WHQ somatic and memory scales (|r| 0.51 – 0.62). FACIT-F fatigue score is highly correlated with the BDI depression score (r < - 0.65). A strong correlation is observed between BR23 body image, WHQ attractiveness and depression, (both WHQ and BDI) scales (|r| 0.54 - 0.6)
Preliminary Fact. Grant Agreement no. TABLE A4 Repeated-measures ANOVA results (p-values). The colour density is proportional to the significance levels 0, 0.001, 0.01 and 0.05. Scale Mixed-effects analysis Conventional analysis C30 Global QoL 0.0000 0.0000 C30 Physical functioning 0.0000 0.0000 C30 Role functioning 0.0192 0.1060 C30 Emotional functioning 0.0152 0.0284 C30 Cognitive functioning 0.7812 0.8000 C30 Social functioning 0.0000 0.0000 C30 Fatigue 0.0000 0.0000 C30 Nausea and vomiting 0.0114 0.0220 C30 Pain 0.0414 0.0181 C30 Dyspnea 0.8269 0.8990 C30 Insomnia 0.0001 0.0003 C30 Appetite loss 0.0003 0.0008 C30 Constipation 0.5867 0.5890 C30 Diarrhea 0.3943 0.3770 C30 Financial impact 0.0000 0.0000 BR23 Body image 0.0000 0.0000 BR23 Sexual functioning 0.0000 0.0000 BR23 Sexual enjoyment 0.1255 0.0881 BR23 Future perspective 0.0000 0.0000 BR23 Systemic therapy side effects 0.0000 0.0000 BR23 Breast symptoms 0.0000 0.0000 BR23 Arm symptoms 0.0000 0.0000 BR23 Upset by hair loss 0.0000 0.0000 WHQ Depressed mood 0.4540 0.5300 WHQ Somatic symptoms 0.2344 0.2710 WHQ Memory/concentration 0.0011 0.0020 WHQ Vasomotor Symptoms 0.0000 0.0000 WHQ Anxiety/fears 0.0478 0.0332 WHQ Sexual behaviour 0.5268 0.3340 WHQ Sleep Problems 0.0161 0.0199 WHQ Menstrual symptoms 0.0000 0.0000 WHQ Attractiveness 0.0481 0.0940 BDI Depression 0.0000 0.0000 FACIT – F score 0.0000 0.0000 D4.1 Preliminary Fact Grant Agreement no.
Preliminary Fact. Grant Agreement no. A data cleaning of the HUJI retrospective dataset is being performed in the framework of WP4. The data cleaning steps performed so far include: o For every variable, comparison of all values to what is listed in the code/explanation manual provided along with the data. In the case of standardized questionnaires, values were compared against questionnaires’ scales and derived overall scores were recalculated.
Preliminary Fact. Grant Agreement no. Figure A9 Graphical representation of the correlation matrix between the various scales at baseline. Positive correlations are displayed in blue and negative correlations in red color. The color intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: Pair wise deletion method was applied. D4.1 Preliminary Fact Grant Agreement no. Figure A10 Graphical representation of the correlation matrix between the various scales at month 3 from baseline. Positive correlations are displayed in blue and negative correlations in red color. The color intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: Pair wise deletion method was applied. D4.1 Preliminary Fact Grant Agreement no. Figure A11 Graphical representation of the correlation matrix between the various scales at month 6 from baseline. Positive correlations are displayed in blue and negative correlations in red color. The color intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: Pair wise deletion method was applied. D4.1 Preliminary Fact Grant Agreement no. Figure 12 Graphical representation of the correlation matrix between the various scales at month 12 from baseline. Positive correlations are displayed in blue and negative correlations in red color. The color intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are left blank. Handling of missing data: Pair wise deletion method was applied. D4.1 Preliminary Fact Grant Agreement no. Figure 13 Graphical representation of the correlation matrix between the various scales at month 24 from baseline. Positive correlations are displayed in blue and negative correlations in red color. The color intensity and the size of the circle are proportional to the correlation coefficients. Not significant correlations (p-value < 0.01) are leaved blank. Handling of missing data: Pair wise deletion method was applied. D4.1 Preliminary Fact Grant Agreement no. Figure A14 Graphical representation of the correlation matrix between the various scales at follow. Positive correlations are displayed in blue and negative correlatio...
