Rationale for the current study Sample Clauses

Rationale for the current study. Emotion regulation is associated with a range of psychopathologies in adulthood and childhood, including internalizing and externalizing disorders, disorders of affect, anxiety, psychosis, and a range of self-regulatory difficulties, specifically substance misuse, eating disorders and self-harm. Associations are reported with both clinical disorder, where ER contributes to the maintenance and severity of disorder, and with vulnerability to the later development of disorder in non-clinical groups. ER is hypothesized to mediate relationships between emotional sensitivity likely to be engendered through genetic predisposition, and/or a range of early adversities or traumatic experiences (particularly disruptions to attachment), and the subsequent development of psychopathology. Intervening to improve emotion regulation should, therefore, have a wide range of positive effects on mental health, and, on adolescent psychiatric units, this is a key component of routine psychological interventions. Historically, research on psychosis has had a strong emphasis on positive symptoms leading to interventions for people with a diagnosis of psychosis and/or experiencing psychotic-like experiences most commonly aiming at reducing the frequency of such positive symptoms and the associate distress. More recently, there is an increase interest in the affective changes in symptoms of psychosis (depression, anxiety) and questions are raised as to whether people with psychosis and/or psychotic-like symptoms experience emotions differently from people with a diagnosis of anxiety or depression and from non-clinical populations. Moreover, it is unclear as to whether attempts to regulate emotions are different between these clinical and non-clinical groups. In order to develop effective interventions for psychosis and psychotic-like experiences, it is therefore important to understand whether PLEs imply different and specific ER strategies independent of emotional distress or disturbance and trauma history. In adults, findings (Xxxxxxx et al., 2013) suggest that ER has a specific association with psychosis: associations with subclinical psychotic-like experiences (e.g. paranoia) have been demonstrated to be independent of the known associations of both psychosis and psychotic-like experiences with trauma history and affective disturbance. This suggests that targeting ER may be particularly helpful in interventions designed to impact on the development and maintenance of psychosis. ...

Rationale for the current study. The purpose of this study is to evaluate the safety of eteplirsen in patients with advanced stage DMD with genetic mutations amenable to treatment by exon 51 skipping.