SNP selection Sample Clauses

SNP selection. The experiments that follow used a candidate gene approach. Resources and time dictated that only a small number of SNPs could be investigated in this thesis. There are around 20,000 genes in the human genome and many millions of SNPs therefore picking a SNP at random will have such a small likelihood of being associated with a given phenotype as to make investigation worthless. Before detailing genotyping methods the process for selecting which SNPs to examine will be discussed. In selecting SNPs we used the following criteria: • Biological plausibility: SNPs had to be in psychosis-relevant pathways. • Support from in vivo or in vitro models: SNPs had to have known functional consequences (e.g. they lead to an amino acid change or are transcription altering). • Prior evidence of genetic association. • Common enough in European samples to warrant investigation in cohorts of the size used in these experiments. On the basis of the above criteria the following four polymorphisms were investigated: 5HTTLPR, COMT val158met, extended MAPT haplotype and HNMT. A full review of the functional significance and supporting evidence for the selection of these polymorphisms is can be found in sections 1.4.1 (5HTTLPR), 1.4.2 (COMT val158met), 1.4.3 (extended MAPT haplotype) and
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Related to SNP selection

  • Shift Selection In multiple shift operations, employees within each classification shall have a right to select their work shift on the basis of their seniority within a bureau or division thereof and competing only with employees covered under this agreement on the following basis:

  • Panel Selection 1. The Parties shall apply the following procedures in selecting a Panel: (a) the Panel shall comprise 3 members; (b) within 15 days following the date of the establishment of the Panel, each Party shall nominate a Panelist; (c) the Parties shall endeavor

  • Single Source Selection Services for tasks in circumstances which meet the requirements of paragraph 3.10 of the Consultant Guidelines for Single Source Selection, may, with the Association's prior agreement, be procured in accordance with the provisions of paragraphs 3.9 through 3.13 of the Consultant Guidelines.

  • Textbook Selection Textbook committees composed of teachers, principals, and the assistant superintendent shall review textbooks and shall make recommendations to the administrative team for consideration. Final selection shall be left to the Board of Education or its authorized representatives.

  • Provider Selection To the extent applicable to Provider in performance of the Agreement, Provider shall comply with 42 CFR 438.214, as may be amended from time to time, which includes, but is not limited to the selection and retention of providers, credentialing and recredentialing requirements and nondiscrimination. If Subcontractor and/or Health Plan delegate credentialing to Provider, Subcontractor and/or Health Plan will provide monitoring and oversight and Provider shall ensure that all licensed medical professionals are credentialed in accordance with Health Plan’s and the State Contract’s credentialing requirements.

  • Vacation Selection Beginning January 2 of each calendar year, employees will be scheduled a time, based on seniority, to select up to three (3) segments of available vacation leave during the time period of April 1 through March 31. A “segment” is one (1) or more contiguous days of vacation leave. No segment shall include more than ten (10) consecutive days of vacation leave in June, July, and/or August, provided that an employee may select contiguous segments of vacation leave. Each employee will be guaranteed one (1) scheduled workweek of vacation leave if requested as one of their segments. Off-shift times to select a vacation will not be considered as “time worked” for purposes of computing callback or overtime. If an employee is unable to be present during their scheduled time they may make their choice by telephone, email, or another individual with written documentation of designation, may select a vacation segment(s) for the employee. If the employee fails to select their vacation during their assigned time, the Employer may proceed with scheduling. The employee will be provided an opportunity to select their segment(s) at a later date when they are available. The Employer will publish the vacation schedule by March 1, after considering requests, as well as Agency program needs. Employees will complete a Leave Request Form no less than thirty (30) days prior to any approved vacation segment taken.

  • Method of Selection Bidder will be selected under Cost Based Selection-L1 (CBS) and procedures described in this Tender Document.

  • Quality-based Selection Services for assignments which the Bank agrees meet the requirements set forth in paragraph 3.2 of the Consultant Guidelines may be procured under contracts awarded on the basis of Quality-based Selection in accordance with the provisions of paragraphs 3.1 through 3.4 of the Consultant Guidelines.

  • Selection of Candidates 5.12 The Appointments Committee shall consider all candidates for a Probationary, Tenured, Limited-Term, Externally-Funded or Visiting position and shall interview all short-listed candidates who present themselves for interview.

  • Least-cost Selection Services for assignments which the Association agrees meet the requirements of paragraph 3.6 of the Consultant Guidelines may be procured under contracts awarded on the basis of Least-cost Selection in accordance with the provisions of paragraphs 3.1 and 3.6 of the Consultant Guidelines.

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