Structure of the Sample Clauses

Structure of the. EACH programme
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Structure of the. REGISTER
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Structure of the extracellular matrix of the heart The normal myocardium is composed of a variety of cells. Cardiac myocytes occupy a major portion of tissue space however represent only one third of all cells. The remaining two thirds and include endothelial and vascular smooth muscle cells of the intramural coronary vasculature and fibroblasts located in both interstitial and perivascular spaces. The cells are tethered within an extracellular scaffolding of fibrillar collagen termed the extra cellular matrix (ECM). The extra cellular matrix (ECM) is made up of a complex lattice of structural proteins e.g. collagen and elastin, as well as adhesive proteins e.g. laminin and fibronectin, which surround the cardiomyocytes. Collagens are the major constituent of the ECM, with the fibrillar collagen types I and III being the most abundant in normal hearts, and their diverse structural properties play an important part in the structure and function of the heart (Xxxxxx et al., 2008). Collagen I has a high tensile strength, which therefore, determines cardiac stiffness, while the distensible property of collagen type III maintains cardiac structure (Xxxxx, 1989). Associated with the collagens are elastic fibers, which are responsible for passive recoil; these fibers are made from an elastin core covered in fibrillin microfibrils. Adhesive proteins including fibronectin, laminin and collagen typeIV bind ECM structural proteins to the cardiomyocytes providing structural support. The ECM is the structural component that maintains the alignment of the myocytes preventing slippage during contraction. As a passive functional component it is the main determinant of diastolic stiffness. However the ECM is not an inert component and plays an essential role in the transmembrane signaling via integrins leading to MAP kinase activation and cytoskeletal rearrangement of the cells tethered to the ECM.
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Structure of the. ALLIANCE -------------------------
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Structure of the. Bitbon System Public Contract
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Related to Structure of the

  • Structure a) The committee will meet as necessary at times determined by the Association and TEBA.

  • Projects There shall be a thirty (30) km free zone around the projects excluding the Metro Vancouver Area. For local residents, kilometers shall be paid from the boundary of the free zone around the project. Workers employed by any contractor within an identified free zone who resides outside of that same free zone will be paid according to the Kilometer Chart from the project to their residence less thirty

  • Project 3.01. The Recipient declares its commitment to the objectives of the Project. To this end, the Recipient shall carry out the Project in accordance with the provisions of Article IV of the General Conditions.

  • Working Facilities During the Term of Employment, the Company shall furnish the Executive with an office, secretarial help and such other facilities and services suitable to his position and adequate for the performance of his duties hereunder.

  • Development 3.3 Within twenty (20) Working Days after the Commencement Date and in accordance with paragraphs 3.10 to 3.12 (Amendment and Revision), the Contractor will prepare and deliver to the Authority for approval the full and final Security Plan which will be based on the draft Security Plan set out in Appendix B.

  • Infrastructure (a) The Borrower has and will maintain a sufficient infrastructure to conduct its business as presently conducted and as contemplated to be conducted following its execution of this Agreement.

  • Office Facilities During the Employment Period, the Company will furnish Executive, without charge, suitable office facilities for the purpose of performing his duties hereunder, which facilities shall include secretarial, telephone, clerical and support personnel and services and shall be similar to those furnished to employees of the Company having comparable positions.

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