TERMINATION 16. UKONČENÍ PLATNOSTI SMLOUVY Sample Clauses

TERMINATION 16. UKONČENÍ PLATNOSTI SMLOUVY. 16.1 The effective date of this Agreement is the date on which it is published in accordance with Act No. 240/2015 Coll., on the register of contracts, as amended.and shall continue in effect for the full duration of the Study according to the Protocol unless sooner terminated in accordance with the provisions of this Section. CRO may terminate this Agreement immediately upon written notice to Institution and Investigator for any reasons, including without limitation upon any of the following occurrences: (a) Institution or Investigator has failed to cure a breach to this Agreement within thirty (30) days of receipt of written notice given by SPONSOR or CRO, specifying such breach; or 16. 1. Tato smlouva nabývá účinnosti k datu, kdy byla tato smlouva zveřejněna dle zákoan č. 240/2015 Sb., o registru smluv, v platném znění a její platnost a účinnost trvá po celou dobu provádění klinického hodnocení v souladu s ustanovením protokolu, pokud nebude předčasně ukončena v souladu s ustanovením tohoto článku této smlouvy. CRO může tuto smlouvu vypovědět s okamžitou platností na základě písemné výpovědi zaslané zdravotnickému zařízení a zkoušejícímu, a to z jakéhokoli důvodu, včetně následujících: (a) zdravotnické zařízení nebo zkoušející nezjednali nápravu při porušení ustanovení této smlouvy do třiceti (30) dnů od obdržení písemného upozornění na konkrétní porušení smlouvy od ZADAVATELE nebo CRO; a/nebo (b) Investigator becomes personally unavailable to conduct the Study and a CRO- approved replacement has not been identified by Institution and Investigator; or (b) stávající zkoušející není schopen dále pokračovat v provádění klinického hodnocení a zdravotnickému zařízení ani zkoušejícímu se nepodařilo získat náhradního zkoušejícího, kterého by ZADAVATEL nebo CRO schválili; nebo
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TERMINATION 16. UKONČENÍ PLATNOSTI SMLOUVY. 16.1 This Agreement will become valid upon the date it is fully executed by all parties and effective upon the date it is published in the registry of contracts. Its validity and effectivity shall continue in effect for the full duration of the Study until the estimated completion of Study in 2027 according to the Protocol unless sooner terminated in accordance with the provisions of this Section. CRO may terminate this Agreement immediately upon written notice to Institution and Investigator for any reasons, including without limitation upon any of the following occurrences: (a) Institution or Investigator has failed to cure a breach to this Agreement within thirty (30) days of receipt of written notice given by SPONSOR or CRO, specifying such breach; or (b) Investigator becomes personally unavailable to conduct the Study and a CRO- approved replacement has not been identified by Institution and Investigator; or (c) two months after shipment of the Investigational Product, Investigator has failed to meet the enrolment target for Subjects set forth in Exhibit A, or has recruited such a low number of Subjects that it can be reasonably assumed by CRO that the agreed number of Subjects will not be reached in accordance with the schedule set forth in Exhibit A; or 16. 1. Tato smlouva nabývá platnosti k datu, kdy svůj podpis připojila poslední ze všech jejích smluvních stran, a účinnosti dnem zveřejnění v registru smluv. Její platnost a účinnost trvá po celou dobu provádění klinického hodnocení v souladu s ustanovením protokolu (do předpokládaného termínu 2027, pokud nebude předčasně ukončena v souladu s ustanovením tohoto článku této smlouvy. CRO může tuto smlouvu vypovědět s xxxxxxxxx xxxxxxxxx xx xxxxxxx xxxxxxx xxxxxxxx zaslané zdravotnickému zařízení a zkoušejícímu, a to z jakéhokoli důvodu, včetně následujících: (a) zdravotnické zařízení nebo zkoušející nezjednali nápravu při porušení ustanovení této smlouvy do třiceti (30) dnů od obdržení písemného upozornění na konkrétní porušení smlouvy od ZADAVATELE nebo CRO; a/nebo (b) stávající zkoušející není schopen dále pokračovat v provádění klinického hodnocení a zdravotnickému zařízení ani zkoušejícímu se nepodařilo získat náhradního zkoušejícího, kterého by ZADAVATEL nebo CRO schválili; nebo (c) pokud do dvou měsíců po dodávce hodnoceného přípravku nesplní Zkoušející cílový počet zařazených subjektů do Klinického hodnocení dle přílohy A nebo pokud do Klinického hodnocení zařadí tak nízký počet subjektů, že ZA...
TERMINATION 16. UKONČENÍ PLATNOSTI SMLOUVY. 16.1. This Agreement will become effective upon the date it is fully executed by all parties and shall continue in effect for the full duration of the Study according to the Protocol unless sooner terminated in accordance with the provisions of this Section. CRO may terminate this Agreement immediately upon written notice to Institution and Investigator for any reasons, including without limitation upon any of the following occurrences: 16. 1. Tato smlouva nabývá účinnosti k datu, kdy svůj podpis připojila poslední ze všech jejích smluvních stran a její platnost a účinnost trvá po celou dobu provádění klinického hodnocení v souladu s ustanovením protokolu, pokud nebude předčasně ukončena v souladu s ustanovením tohoto článku této smlouvy. CRO může tuto smlouvu vypovědět s xxxxxxxxx xxxxxxxxx xx xxxxxxx xxxxxxx xxxxxxxx zaslané poskytovateli a zkoušejícímu, a to z jakéhokoli důvodu, včetně následujících: (a) Institution or Investigator has failed to cure a breach to this Agreement within thirty (30) days of receipt of written notice given by SPONSOR or CRO, specifying such breach; or

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  • Termination; General The Representatives may terminate this Agreement, by notice to the Company, at any time at or prior to Closing Time (i) if in the reasonable judgment of the Representatives, there has been, since the time of execution of this Agreement or since the respective dates as of which information is given in the Prospectus or the General Disclosure Package, any material adverse change in the condition, financial or otherwise, or in the earnings, business affairs, financial prospects or business prospects of the Company and its subsidiaries considered as one enterprise, whether or not arising in the ordinary course of business, or (ii) if there has occurred any material adverse change in the financial markets in the United States or the international financial markets, any outbreak of hostilities or escalation thereof or other calamity or crisis or any change or development involving a prospective change in national or international political, financial or economic conditions, in each case the effect of which is such as to make it, in the judgment of the Representatives, impracticable or inadvisable to market the Securities or to enforce contracts for the sale of the Securities, or (iii) if trading in any securities of the Company has been suspended or limited by the Commission, the New York Stock Exchange or the Nasdaq Global Market, or if trading generally on the NYSE American or the New York Stock Exchange or in the Nasdaq Global Market has been suspended or limited, or minimum or maximum prices for trading have been fixed, or maximum ranges for prices have been required, by any of said exchanges or by such system or by order of the Commission, the FINRA or any other governmental authority, or a material disruption has occurred in commercial banking or securities settlement or clearance services in the United States, or (iv) if a banking moratorium has been declared by either Federal, California or New York authorities, or (v) if since the date of this Agreement, there has occurred a downgrading in the rating assigned to the Securities, any class or series of the Company’s outstanding Preferred Stock, if any, or any of the Company’s other debt securities by any nationally recognized securities rating agency, or any such securities rating agency has publicly announced that it has under surveillance or review, with possible negative implications or without indicating the direction of the possible change, its rating of the Securities, any class or series of Preferred Stock or any of the Company’s other debt securities.

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