Slope factor definition

Slope factor. , also known as "q1*", means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.
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Slope factor means the plausible upper-bound estimate of the probability of a response (cancer) per unit intake of chemical over a lifetime. Also referred to as Potency Factor.
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Slope factor means an upper bound estimate that approximates a 95 percent confidence limit of the increased cancer risk from a lifetime exposure to a contaminant. This estimate is expressed in units of the proportion of a population that is affected per milligram per day exposure to the contaminant per kilogram of body weight of the exposed individual.
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Examples of Slope factor in a sentence

  • Slope factor and carcinogen group of arsenic are those listed in IRIS under arsenic (inorganic); RfDs of chromium, mercury, and nickel are those listed in IRIS under chromium (VI), mercuric chloride, and nickel (soluble salts), respectively.

  • Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

  • Slope factor setting; (j) Shade factor setting; and (k) Irrigation uniformity or efficiency setting.

  • Where: C = Concentration of contaminant (soil: mg/kg, water: mg/l) RF = Risk factor For protection from cancer health risks:RF = TR ÷ SFWhere: TR = Target cancer risk (unitless)SF = Slope factor [(mg/kg)/day]-1 for a route of exposure; see paragraph “c” for source.

  • It Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

  • Slope factor: An upper bound, approximating a 95% confidence limit, on the increased cancer risk from a lifetime exposure to an agent.

  • Slope factor (SF) - a plausible upper-bound estimate of the probability of a carcinogenic response per unit intake of a constituent over a lifetime; EPA toxicity value for a constituent that elicits carcinogenic health effects.

  • Secondary Maximum Contaminant Level (SMCL) is given if applicable.B RfD: Chronic oral reference dose for non-carcinogenic toxic health effects based on findings of No Observable Adverse Effect Level (NOAEL) or Lowest Observable Adverse Effect Level (LOAEL).C SF: Slope factor is the upper-bound incremental risk of developing cancer due to lifetime exposure to a particular unit intake.D Chronic refers to the health effects due to long term exposure to the contaminant (e.g., exposure over many years).

  • Slope factor is the cancer risk (proportion affected) per unit of dose.

  • Select Slope to recalculate the Slope factor M (Multiplier) or Offset to recalculate the offset calibration factor A (Adder).


More Definitions of Slope factor

Slope factor means the incremental rate of cancer development calculated using a linearized multistage model or other appropriate model. It is expressed in milligrams per kilogram per day of exposure to the chemical in question and is also known as q1*.
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Slope factor or "Q1*" means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. It is expressed in (mg/kg/day) of exposure to the chemical in question.
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Slope factor means the upperbound estimate of probability in the occurrence of excess cancer risk (increase in cancer risk over the background risk) associated with a specific carcinogen for an individual who is exposed to a unit of intake over lifetime. The unit for a slope factor is the probability per unit intake, i.e., the inverse of milligram per kilogram body weight (mg/Kg/day)-1.
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Slope factor or "Q *" means the incremental rate of cancer development calculated through use o1 f a linearized multistage model or other appropriate
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Related to Slope factor

  • Weighting factor wT for an organ or tissue (T) means the proportion of the risk of stochastic effects resulting from irradiation of that organ or tissue to the total risk of stochastic effects when the whole body is irradiated uniformly. For calculating the effective dose equivalent, the values of wT are:

  • Leverage Factor means the leverage factor in respect of a Series of ETP Securities as specified in the relevant Final Terms.

  • Fit factor means a quantitative estimate of the fit of a particular respirator to a specific individual, and typically estimates the ratio of the concentration of a substance in ambient air to its concentration inside the respirator when worn.

  • Power Factor means the ratio of usage power measured in kW to total power measured in kVA;

  • Loss Factor means the scaling factor determined in accordance with clause 7 and applied by the reconciliation manager to volumes of electricity measured or estimated in respect of ICPs on the Network, in order to reflect the impact of the ICP on Losses within the Network;

  • Performance Factor means any matter that could or will significantly affect a party’s ability to fulfill its obligations under this Agreement;

  • Adjustment Factor means, with respect to a share of the Fund (or one unit of any other security for which a Fund Closing Price must be determined), 1.0, subject to adjustment in the event of certain events affecting the shares of the Fund. See “—Anti-dilution Adjustments Relating to the Fund; Alternate Calculation —Anti-dilution Adjustments” below.

  • Interest Factor means monthly compounding, discounting or annuitizing, as applicable, at a rate set forth in Exhibit A.

  • Capacity factor means the ratio of the average load on a machine or equipment for the period of time considered to the capacity rating of the machine or equipment.

  • Performance Factors means any of the factors selected by the Committee and specified in an Award Agreement, from among the following objective measures, either individually, alternatively or in any combination, applied to the Company as a whole or any business unit or Subsidiary, either individually, alternatively, or in any combination, on a GAAP or non-GAAP basis, and measured, to the extent applicable on an absolute basis or relative to a pre-established target, to determine whether the performance goals established by the Committee with respect to applicable Awards have been satisfied:

  • Multiplier means 1.0.

  • Limited Indexation Factor means, in respect of a Limited Indexation Month or Limited Indexation Date, as the case may be, the ratio of the Index Figure applicable to that month or date, as the case may be, divided by the Index Figure applicable to the month or date, as the case may be, twelve months prior thereto, provided that (a) if such ratio is greater than the Maximum Indexation Factor specified in the relevant Final Terms, it shall be deemed to be equal to such Maximum Indexation Factor and (b) if such ratio is less than the Minimum Indexation Factor specified in the relevant Final Terms, it shall be deemed to be equal to such Minimum Indexation Factor;

  • Weighting with respect to an Underlying means the weighting in relation to the relevant Underlying as specified in the table in the definition of such Underlying.

  • Required Reserve Factor Floor means, for any Calculation Period, the sum (expressed as a percentage) of (a) 28.00% plus (b) the product of the Adjusted Dilution Ratio and the Dilution Horizon Ratio, in each case, as of the immediately preceding Cut-Off Date.

  • Lowest achievable emission rate (LAER) means for any source, that rate of emissions which reflects the most stringent emission limitation which is contained in the implementation plan of any State for such class or category of source, unless the owner or operator of the proposed source demonstrates that such limitations are not achievable, or the most stringent emission limitation which is achieved in practice by such class or category of source, whichever is more stringent. In no event shall the application of this term permit a proposed new or modified source to emit any pollutant in excess of the amount allowable under applicable New Source Standards of Performance.