Slope factor definition

Slope factor. , also known as "q1*", means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

Slope factor means the plausible upper-bound estimate of the probability of a response (cancer) per unit intake of chemical over a lifetime. Also referred to as Potency Factor.

Slope factor means an upper bound estimate that approximates a 95 percent confidence limit of the increased cancer risk from a lifetime exposure to a contaminant. This estimate is expressed in units of the proportion of a population that is affected per milligram per day exposure to the contaminant per kilogram of body weight of the exposed individual.

Examples of Slope factor in a sentence

• Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

• Where: C = Concentration of contaminant (soil: mg/kg, water: mg/l) RF = Risk factor For protection from cancer health risks:RF = TR ÷ SFWhere: TR = Target cancer risk (unitless)SF = Slope factor [(mg/kg)/day]-1 for a route of exposure; see paragraph “c” for source.

• It Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

• Hazard Quotient (HQ) = Chronic Daily Intake/RfD Cancer Risk = Chronic Daily Intake x Slope factor or Unit Risk Factor Of greater interest for those concerned with the health of workers, building occupants and school children is the paucity of data with respect to the exposure to specific congeners.

• Select Slope to recalculate the Slope factor M (Multiplier) or Offset to recalculate the offset calibration factor A (Adder).

• Slope factor was grouped into four parts (< 1%, 1–2%, 2–3%, > 3%) and buffer zone scored as 1, 2, 3 and 4, respectively.

• Each of the input layers (e.g. Rainfall Erosivity, Soil Erodibility, Slope factor, population densities etc.) is explained well in the model developed.

• The excess lifetime carcinogenic risk can be estimated by multiplying Average Daily Dose (ADD) with Slope factor (SF) and the duration of life (75.2 years).

• Table 7-1Calculation of Carcinogenic Toxicity Screen ChemicalNotes:Cmax: Maximum concentration SF: Slope factor (kg-day/mg)Site toxicity: Sum of toxicity score for each media.

• Pair-wise comparison matrix of triangular fuzzy-AHP for GWP evaluation Factors 41Where: LF denotes Landform factor, RF denotes Rainfall factor, LD denotes Lineament Density factor, LITH denotes Lithology factor, DD denotes Drainage Density factor, SO denotes Soil factor, SL denotes Slope factor and LULC denotes Land use/cover factor.

More Definitions of Slope factor

Slope factor means the incremental rate of cancer development calculated using a linearized multistage model or other appropriate model. It is expressed in milligrams per kilogram per day of exposure to the chemical in question and is also known as q1*.

Slope factor or "Q1*" means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. It is expressed in (mg/kg/day) of exposure to the chemical in question.

Slope factor means the upperbound estimate of probability in the occurrence of excess cancer risk (increase in cancer risk over the background risk) associated with a specific carcinogen for an individual who is exposed to a unit of intake over lifetime. The unit for a slope factor is the probability per unit intake, i.e., the inverse of milligram per kilogram body weight (mg/Kg/day)-1.

Slope factor or "Q *" means the incremental rate of cancer development calculated through use o1 f a linearized multistage model or other appropriate