Cocaine Sample Clauses

Cocaine. Cocaine was initially produced from the coca plant of South America, and in that form has been used as a stimulant for over 1000 years (reviewed in (Xxxxxxxx and Xxxxxxxx, 1989)). In the last 100 years, the active ingredient was isolated, synthesized, and while it was originally used as a supplement and a treatment for a variety of ailments, it is currently most often used illicitly as a recreational drug. The acute effects of cocaine on sleep are similar to those of amphetamine and include longer sleep latency, decreased total sleep time, and decreased REM (Boutrel and Xxxx, 2004; Xxxxxxxxxxxx et al., 2008). Insomnia is a frequent adverse effect of cocaine. In addition, much like amphetamine, cocaine also increases locomotor activity in animal models. Abuse of cocaine in humans leads to sleep disturbances, most frequently fragmented sleep and alterations in REM (Xxxxxxxxxx and Xxxxx, 2007). Even during abstinence from cocaine, some of these disturbances continue. However, modafinil is able to normalize sleep architecture and decrease daytime sleepiness in cocaine-dependent subjects (Xxxxxx et al., 2010). Modafinil has also been shown to be effective at reducing cocaine intake in cocaine-dependent individuals, and this may indicate that improving sleep quality is an important factor in that reduction (Dackis et al., 2005; Xxxx et al., 2008). Cocaine acts by inhibiting the monoamine transporters, and thereby increasing extracellular concentrations of DA, NE, and 5-HT. All of these neurotransmitters are important for arousal, and their primary nuclei are parts of the ascending arousal pathway. The locomotor effects of cocaine seem primarily due to its inhibition of DAT. Cocaine-induced locomotor behavior is normal in NE transporter (NET) and SERT KO mice, but DAT KO mice are nonresponsive to acute cocaine (Hall et al., 2009). DAT KO mice also exhibit decreased self- administration of cocaine, indicating that DA is also responsible for at least some of the rewarding effects of this drug (Xxxxxxx et al., 2009). However, while DAT blockers such as JHW007 can occlude the locomotor effects of cocaine (Xxxxx et al., 2005), cocaine-induced locomotion is also significantly decreased in mice lacking the α1bAR (Xxxxxx et al., 2001). Furthermore, when pretreated with an α1AR antagonist, mice displayed decreased development and expression of cocaine sensitization (Xxxxxxx-Xxxxxx et al., 2006). In-depth studies of cocaine on sleep utilizing EEG monitoring have not been c...
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Cocaine 

Related to Cocaine

  • Infection Control Consistent with the Centers for Disease Control and Prevention Guideline for Infection Control in Health Care Personnel, and University Policy 3364-109-EH-603, the parties agree that all bargaining unit employees who come in contact with patients in the hospital or ambulatory care clinics will need to be vaccinated against influenza when flu season begins each fall. The influenza vaccine will be offered to all health care workers, including pregnant women, before the influenza season, unless otherwise medically contraindicated or it compromises sincerely held religious beliefs.

  • Rhytidectomy Scar revision, regardless of symptoms. • Sclerotherapy for spider veins. • Skin tag removal. • Subcutaneous injection of filling material. • Suction assisted Lipectomy. • Tattooing or tattoo removal except tattooing of the nipple/areola related to a mastectomy. • Treatment of vitiligo. • Standby services of an assistant surgeon or anesthesiologist. • Orthodontic services related to orthognathic surgery. • Cosmetic procedures when performed primarily: o to refine or reshape body structures or dental structures that are not functionally impaired; o to improve appearance or self-esteem; or o for other psychological, psychiatric or emotional reasons. • Drugs, biological products, hospital charges, pathology, radiology fees and charges for surgeons, assistant surgeons, attending physicians and any other incidental services, which are related to cosmetic surgery.

  • Influenza Vaccination The parties agree that influenza vaccinations may be beneficial for patients and employees. Upon a recommendation pertaining to a facility or a specifically designated area(s) thereof from the Medical Officer of Health or in compliance with applicable provincial legislation, the following rules will apply:

  • Drugs Possession or use of drugs by the Student, any person present in the residence with the Student, or any person present in the Student’s residence with the permission of the Student during the Student’s absence, are strictly prohibited in any UCF DHRL facility. Prohibited drugs include, but are not limited to:

  • SUBSTANCE ABUSE The dangers and costs that alcohol and other chemical abuses can create in the electrical contracting industry in terms of safety and productivity are significant. The parties to this Agreement resolve to combat chemical abuse in any form and agree that, to be effective, programs to eliminate substance abuse and impairment should contain a strong rehabilitation component. The local parties recognize that the implementation of a drug and alcohol policy and program must be subject to all applicable federal, state, and local laws and regulations. Such policies and programs must also be administered in accordance with accepted scientific principles, and must incorporate procedural safeguards to ensure fairness in application and protection of legitimate interests of privacy and confidentiality. To provide a drug-free workforce for the Electrical Construction Industry, each IBEW local union and NECA chapter shall implement an area-wide Substance Abuse Testing Policy. The policy shall include minimum standards as required by the IBEW and NECA. Should any of the required minimum standards fail to comply with federal, state, and/or local laws and regulations, they shall be modified by the local union and chapter to meet the requirements of those laws and regulations.

  • Infectious Diseases The Employer and the Union desire to arrest the spread of infectious diseases in the nursing home. To achieve this objective, the Joint Health and Safety Committee may review and offer input into infection control programs and protocols including surveillance, outbreak control, isolation, precautions, worker education and training, and personal protective equipment. The Employer will provide training and ongoing education in communicable disease recognition, use of personal protective equipment, decontamination of equipment, and disposal of hazardous waste.

  • Chemical Dependency Alcoholism and drug addiction shall be recognized as an illness. However, sick leave pay for treatment of such illness shall be contingent upon two conditions: 1) the employee must undergo an evaluation by a licensed alcohol and drug counselor or substance abuse professional, and 2) the employee, during or following the above care, must participate in a prescribed program of treatment and rehabilitation approved by the Employer in consultation with the Employer's health care provider.

  • Influenza Vaccine Upon recommendation of the Medical Officer of Health, all employees shall be required, on an annual basis to be vaccinated and or to take antiviral medication for influenza. If the costs of such medication are not covered by some other sources, the Employer will pay the cost for such medication. If the employee fails to take the required medication, she may be placed on an unpaid leave of absence during any influenza outbreak in the home until such time as the employee has been cleared by the public health or the Employer to return to the work environment. The only exception to this would be employees for whom taking the medication will result in the employee being physically ill to the extent that she cannot attend work. Upon written direction from the employee’s physician of such medical condition in consultation with the Employer’s physician, (if requested), the employee will be permitted to access their sick bank, if any, during any outbreak period. If there is a dispute between the physicians, the employee will be placed on unpaid leave. If the employee gets sick as a reaction to the drug and applies for WSIB the Employer will not oppose the application. If an employee is pregnant and her physician believes the pregnancy could be in jeopardy as a result of the influenza inoculation and/or the antiviral medication she shall be eligible for sick leave in circumstances where she is not allowed to attend at work as a result of an outbreak. This clause shall be interpreted in a manner consistent with the Ontario Human Rights Code.

  • Alcohol & Drugs I understand that the possession or consumption of alcoholic beverages or illegal substances is prohibited at all game locations and Activities hosted by the Club. I understand that by not following the rules of the game, or by playing while intoxicated, or if there is any suspicion of intoxication, I will not be allowed to play and will not receive a refund.

  • Infectious Disease Where an employee produces documentary evidence that:

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