Dependence. Physical dependence is an expected side effect of long-term opioid/narcotic therapy. This means that if you take opioids/narcotics continuously, and then stop them abruptly, you will experience a withdrawal syndrome. This syndrome often includes sweating, diarrhea, irritability, sleeplessness, runny nose, tearing, muscle and bone aching, gooseflesh, and dilated pupils. Withdrawal can be life-threatening. To prevent these symptoms, the opioids/narcotics should be taken regularly or, if discontinued, reduced gradually under the supervision of your physician.
Dependence. After prolonged use, some people will have withdrawal symptoms if they abruptly stop these medications. Such symptoms may include most all of the behavioral side effects discussed above; depression can be quite severe. This problem is much more common following misuse/excessive use of such medications. There is significant potential for abuse of these medications, either by the patient or by persons who obtain them from the patient.
Dependence. If the licensee fails or underperforms, it could significantly impact the revenue generation from the licensed property. Thus, it is important to introduce minimal fees (Section 4.7).
Dependence. “Dependence” on gambling shall be defined as a beneficiary routinely or frequently participating in gaming activities, and expending significant amounts of property on these activities, to the extent that a mental health professional such as a therapist, psychiatrist or psychologist could reasonably concur that the beneficiary is psychologically dependent upon these activities. An actual diagnosis of dependency on gambling need not be submitted by a medical professional in order to enact the presumption of this prerequisite: No tests must actually be performed by such a medical professional for the Trustee to determine that the beneficiary is dependent upon the behavior; the Trustee need to only have a reasonable suspicion that such dependency does exist..
Dependence. After prolonged use, most people will have withdrawal symptoms if they abruptly stop narcotic pain medications. Such symptoms include rapid heart rate, elevated blood pressure, sweating, nausea and vomiting, diarrhea, body aches, abdominal pain, psychosis, and hallucinations. These are very uncomfortable, but rarely life- threatening.
Dependence. All people on long term narcotics will develop a physical dependence on narcotics. This means that after being on the medication for a period of time, sudden cessation of this drug will lead to withdrawal symptoms and intense craving for the medication. Chronic narcotics can not be stopped suddenly. If the patient decides to stop the medication the patient will need to be weaned off the medication.
Dependence. Both tolerance and physical dependence can develop during chronic opioid therapy. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Tolerance may occur to both the desired and undesired effects of drugs, and may develop at different rates for different effects. Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug. Withdrawal also may be precipitated through the administration of drugs with opioid antagonist activity (e.g., naloxone, nalmefene), mixed agonist/antagonist analgesics (e.g., pentazocine, butorphanol, nalbuphine), or partial agonists (e.g., buprenorphine). Physical dependence may not occur to a clinically significant degree until after several days to weeks of continued opioid usage. APADAZ should not be abruptly discontinued in a physically-dependent patient [see Dosage and Administration (2.5)]. If APADAZ is abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other signs and symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal signs [see Use in Specific Populations (8.1)].
