LABORATORY QUALITY CONTROL REQUIREMENTS. 31 The laboratory will be selected on a site-by-site basis. As such, the laboratory QAM will 32 be included with the Site-specific QAPP Addenda. The Site-specific QAPP Addenda will 33 reference the appropriate sections of the laboratory QAM which detail the laboratory QC 34 requirements. If the information is not included in the laboratory QAM, the information 35 will be detailed in Section B6 of the Site-specific QAPP Addenda. To monitor the 36 achievement of the data quality objectives identified in the Site-specific QAPP Addenda, 37 precision, accuracy, representativeness, completeness, and comparability will be 38 assessed in accordance with the previously cited sections of each laboratory’s QAM. 39 Precision will be assessed by examining field and matrix spike duplicate (MSD) 40 analytical results. Laboratory accuracy will be assessed by performing recovery studies, 1 including matrix spike (MS), laboratory control samples, and laboratory method blank 2 analytical results. The Site-specific QAPP Addenda will provide a table with ranges of 3 precision and accuracy considered acceptable for the CoC. If quality issues are 4 identified, the laboratory will follow the corrective action procedures detailed in their 5 QAM.
LABORATORY QUALITY CONTROL REQUIREMENTS. 1 This information is provided in the Generic QAPP document. In addition, the laboratory
LABORATORY QUALITY CONTROL REQUIREMENTS. Detailed laboratory QC requirements are contained within each analytical laboratory’s Standard Operating Procedures (SOP) and are also available upon request. Laboratory quality control procedures include the following practices. Laboratory replicate – Laboratory replicates are used to assess precision. A laboratory replicate is prepared by splitting aliquots of a single sample (or a matrix spike or a laboratory control standard) in the laboratory after prep techniques have been completed. Both samples are carried through the entire analytical process. Laboratory replicates are performed on 10% of samples analyzed. Precision is calculated by the relative percent difference (RPD) of duplicate results as defined by 100 times the difference (range) of each replicate set, divided by the average value (mean) of the set. For replicate results, D1 and D2, the RPD is calculated from the following equation: RPD = (D1 − D2) ∗ 100 (D1 − D2)⁄2 Equation ES-2: Laboratory Replicate Relative Percent Difference Laboratory Control Standard (LCS) – A laboratory control sample is analyte-free water spiked with the analyte of interest prepared from standardized reference material. The laboratory control standard is generally spiked at a level less than or equal to the mid-point of the calibration curve for each analyte. The LCS is carried through the complete preparation and analytical process. The LCS is used to document the accuracy of the method due to the analytical process. LCS’s are generally run at a rate of one per batch. Acceptability criteria are laboratory specific and usually based on results of past laboratory data. The analysis of LCS’s is a measure of accuracy and is calculated by Percent Recovery (%R) and defined as 100 times the observed concentration, divided by the true concentration of the spike. Acceptance criteria are based on laboratory control charts, but not greater than the prescribed criteria. The formula used to calculate percent recovery, where %R is percent recovery includes SR as the sample result and SA as the spike added: Percent R = SR ∗ 100⁄SA Equation ES-3: Laboratory Control Standard Percent Recovery Matrix spikes (MS) – A matrix spike is an aliquot of sample spiked with a known concentration of the analyte of interest. Percent recovery of the known concentration of added analyte is used to assess accuracy of the analytical process. The spiking occurs prior to sample analysis. The MS level varies based on the method but is typically spike...
LABORATORY QUALITY CONTROL REQUIREMENTS. This information was provided in Section B6 of the Generic QAPP. In addition, Pace Analytical’s QAM is provided in Appendix D.
