Model Analysis. To the extent a Deliverable is used by or for JPMC to value positions, measure exposure or evaluate risk (collectively, the “Models”), including to facilitate JPMC’s compliance with regulatory and management requirements to fully understand and explain the Models used for its businesses, promptly after request from JPMC and at no additional charge, Supplier will (a) deliver to JPMC documentation sufficient to enable a detailed understanding of the methodology, analysis and calculations that are referenced, included or implemented in the development or use of the Models (collectively, “Model Analysis”) so as to enable JPMC to review and explain the Models; and (b) make qualified Supplier Personnel available to JPMC and its designees (including regulators and other Auditors) to provide “plain English” explanations of any such Models or Model Analysis. Any such documentation and explanation is subject to Section 11.”
Model Analysis. The two original models for the TCR and TLR5 signaling pathways were merged and the logical rules of shared nodes were updated to take into account the additional regulatory inputs (Fig. 5, Table S4, and File 5). We computed the stable states of the two original and merged models under wild-type and mutant conditions. We further generated a reduced version of the merged model (Fig. S4) to explore its dynamical behavior. All of the analyses were performed with GINsim [as previously described (81–84)], which supports model reduction by hiding selected (intermediate) nodes. Provided that no functional regulatory circuit is eliminated in the process, this reduction preserves all attractors (81). The dynamical behavior of a logical model is represented by a State Transition Graph (STG). In this graph, each node represents a state of the model, which is defined by a vector encompassing the levels of all components, and the arcs represent transitions between states. One core function of GINsim is the automatic construction of this graph (82). When the number of components in a model is large, the resulting STG becomes difficult to compute and to visualize. In this respect, GINsim enables the generation of a Hierarchical Transition Graph (HTG), which is computed by clustering the nodes of a STG into groups of states (hyper-nodes) sharing the same set of successors (84). Finally, computing the HTG for different initial conditions enabled us to identify all of the attractors of our merged model for wild-type and mutant scenarios (see Results). Cell isolation and culture Leukocyte concentrates were obtained from healthy donors from the “Centro Estatal de la Transfusión Sanguínea”, Cuernavaca, Mexico. Peripheral blood mononuclear cells (PBMCs) were obtained from these cellular concentrates through centrifugation with ficoll-hypaque gradient. Total CD4+ T cells were obtained using the RosetteSep CD4+ T cell enrichment cocktail (Stem Cell) and 1 ml of erythrocytes from the same donor. We depleted memory cells with an anti- CD45RO antibody (Tonbo) coupled to magnetic beads (Xxxxxx) with the help of a magnetic rack. Naive CD4+ T cells obtained this way were cultured in RPMI medium supplemented with 5% fetal bovine serum (FBS) at 37°C with 5% CO2. Cell preparations were routinely checked for purity and were at least 96% CD3+CD4+, CD45RO-, and 96% CCR7+CD62L+. CD4+ T cell stimulation Naive CD4+ T cells were either left unstimulated or stimulated by cross-linking the CD3 rec...
Model Analysis. We consider a situation where the SP is the only provider of compensation received by the owner (see 3.2). For case (i), the expected utility function is ⎛ − N ( ,ν )⎛ 2− λ + ∞ e− rCp ( x−v ) g ( x)dx− verCI (v−x ) g ( x)dx ⎞ ⎞ 1 −r(ϒτ − P −C ) y ⎜ λ −ϒr ∫v ∫0 ⎟ E ⎡⎣U y (O2 )⎤⎦ = ⎜1− e G b e ⎝ ⎠ ⎟ (8) r ⎜ ⎟ ⎝ ⎠ For case (ii),the expected profit of the owner is given by (5) and (7) replacing W with Wy and L with Ly.
Model Analysis. We adopt a backward induction to solve the problem from the second period to the first period. According to the revenue functions of the distributor and the theater, we analyze how the distributor sets the contract to maximize his revenue and how the theater decides the number of movie screening to maximize her revenue. There are two types of contracts for distributor. One is no-promotion contract and the other is promotion contract. In brief, if the distributor’s revenue in providing no- promotion contract is higher than that in providing a promotion contract, then he will offer a no-promotion contract to the theater and the theater consequently will also not adopt promotional efforts, and vice versa.
