Structure of Decision Tree models Sample Clauses

Structure of Decision Tree models. The protection for each vaccination coverage, number of people vaccinated, was reflected in the value of the vaccine effective branch. For example at the vaccine effective branch, 75% vaccination coverage is calculated as 75% of vaccinees mounting an adequate and protective immune response to the vaccine (44%, vaceffective variable value) and results in 33% protected among vaccinees. The outcomes are represented by the variables healthy, case and dead which are estimated to be valued at 1, 0.5 and 0 quality adjusted life years (QALYs). Most of the model variables included lower and upper bound values based on assumptions, calculated or estimated (Table 1, 2). In addition to evaluating vaccination coverage options, the models accessed the potential paths from infection to outcome in the context of three scenarios: H5N1, 1918 H1N1 and 2009 H1N1 (Table I). The H5N1 model utilizes data from sporadic cases with high case fatality (59%) which is highly specific but has low sensitivity since the WHO surveillance case definition of the data only includes laboratory confirmed cases (3). On the other hand, the 1918 H1N1 model utilizes a combination of not specific but sensitive data generated by symptom-based mortality statistics and house-to-house surveys for a moderate case fatality pandemic (0.25%-2.33%) (31-33). The 2009 H1N1 model is derived from moderately specific and sensitive data that is a combination of laboratory confirmation, mortality statistics, hospital and community studies for a low case fatality pandemic (0.011%-0.066%) (34-35). Table 1. Decision Tree Model Variables Name Description Root Low High Source Variables Common to All Models infected infection resulting from an exposure- related activity 0.50 0.10 0.90 (24) vaceffective antibody titer > 1:40 measured 28 0.44 0.34 0.55 (17) days after second dose via HI assay vaccost cost of vaccine only + 2011 inflation 83.80 - - calculated adjustment (22, 25) vaccostadm [vaccine administration (20 min of 94.92 - - calculated nurse time for 2 doses) + cost-of- (22, 25-27) living adjustment estimation] + vaccost diedcost [treatment + 2011 inflation adjustment] + vaccost 16077.73 11678.5 16077.73 (22, 25, 28) diedcostadm [treatment + 2011 inflation 16088.85 11689.62 16088.85 (22, 25, 27-28) adjustment] + vaccostadm nonfatalcost [treatment + 2011 inflation 8657.17 331.84 11678.5 (22, 25, 28-29) adjustment] + vaccost nonfatalcostadm [treatment + 2011 inflation 8668.29 342.96 11689.62 (22, 25-29) adjustment] ...
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