Use of Animals in Laboratory Testing. Each Party agrees, and shall cause its Affiliates and contractors to agree, to comply with the “3R” principles with respect to the use of animals in each R&D Program — reducing the number of animals used, replacing animals with non-animal methods whenever possible and refining the research techniques used. All work must be conducted in accordance with the core principles identified below, in addition to all relevant statutes, legislation, regulations and guidelines for the care, welfare and ethical treatment of animals used in research in the country where the activities under the applicable R&D Program are being performed.
2.13.1 The principles set forth below describe minimum standards; local customs, norms, practices or laws may be additive to such principles.
a. Access to species appropriate food and water;
b. Access to species specific housing, including species appropriate temperature and humidity levels;
c. Access to humane care and a program of veterinary care; EXECUTION COPY Confidential
d. Ability to demonstrate species specific behavior;
e. Study design reviewed by institutional ethical review panel;
f. Commitment to minimizing pain and distress during in vivo studies; and
g. Work performed by appropriately trained staff.
2.13.2 KineMed shall permit GSK to conduct reasonable inspections, at GSK’s sole expense and no more frequently than twice per Calendar Year, upon at least *** (***) calendar days’ prior written notice, and during regular business hours, in order for GSK to confirm adherence to the above principles and guidelines. To the extent that any material deficiencies are identified as the result of such inspection, KineMed shall endeavor in good faith to take reasonable and practical corrective measures to remedy any such material deficiencies.
Use of Animals in Laboratory Testing. Each Party agrees, and shall cause its Affiliates and Contractors to agree, to comply with the “3R” Principles with respect to the use of animals in the Research Program—reducing the number of animals used, replacing animals with non-animal methods whenever possible and refining the research techniques used. All work must be conducted in accordance with the core principles identified below, in addition to all relevant statutes, legislation, regulations and guidelines for the care, welfare and ethical treatment of animals used in research in the country where the Research Program is being performed. The principles set forth below describe minimum standards; local customs, norms, practices or laws may be additive to such principles.
a) Access to species appropriate food and water;
b) Access to species specific housing, including species appropriate temperature and humidity levels;
c) Access to humane care and a program of veterinary care;
d) Ability to demonstrate species specific behavior;
e) Study design reviewed by institutional ethical review panel;
f) Commitment to minimizing pain and distress during in vivo studies, and
g) Work performed by appropriately trained staff. FivePrime shall permit GSK to conduct reasonable inspections, at GSK’s sole expense and no more frequently than twice per Calendar Year, upon at least *** calendar days’ prior written notice, and during regular business hours, in order for GSK to confirm adherence to the above principles and guidelines. To the extent that any material deficiencies are identified as the result of such inspection, FivePrime shall endeavor in good faith to take reasonable and practical corrective measures to remedy any such material deficiencies.
Use of Animals in Laboratory Testing. Each Party agrees, and shall cause its Affiliates and Contractors to agree, to comply with the “3R” Principles with respect to the use of animals in the Research Program -- reducing the number of animals used, replacing animals with non-animal methods whenever possible and refining the research techniques used. All work must be conducted in accordance with the core principles identified below, in addition to all relevant statutes, legislation, regulations and guidelines for the care, welfare and ethical treatment of animals used in research in the country where the Research Program or the FivePrime Early Development Plan is being performed. The principles set forth below describe minimum standards; local customs, norms, practices or laws may be additive to such principles.
a) Access to species appropriate food and water;
b) Access to species specific housing, including species appropriate temperature and humidity levels;
c) Access to humane care and a program of veterinary care;
d) Ability to demonstrate species specific behavior;
e) Study design reviewed by institutional ethical review panel;
