Prohibited Medications Sample Clauses

Prohibited Medications. Subjects who require treatment during the course of the study with either an anticonvulsant (phenobarbital, phenytoin, carbamazepin or primidone) or chronic treatment with any form of heparin will be discontinued. Estrogens given as HRT are allowed at entry into the study but cannot be initiated during the study except for local low dose vaginal estrogen. Drugs that may compromise renal function such as non-steroidal anti-inflammatory drugs should be used with caution.
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Prohibited Medications. Restrictions on specific classes of medications include the following and any use of these medications during the specified time periods must be documented as protocol deviations: • Initiation of new psychotropic medications, including antidepressant or antianxiety medications, and any new pharmacotherapy regimens that may potentially have an impact on efficacy and/or safety endpoints within 30 days prior to Day 1 through completion of the Day 45 visit • Use of any benzodiazepines, barbiturates, GABAA modulators (eg, eszopiclone, zopiclone, zaleplon, and zolpidem) within 28 days prior to Day 1 through completion of the Day 45 visit (within 30 days prior to Day 1 through completion of the Day 45 visit for benzodiazepine or GABA modulators with a half-life of ≥48 hours [eg, diazepam) • First generation (typical) antipsychotics (eg, haloperidol, perphenazine) and second generation (atypical) antipsychotics (eg, aripiprazole, quetiapine) within 14 days prior to Day 1 through completion of the Day 45 visit • Use of any non-GABA anti-insomnia medications (eg, melatonin, Benadryl [antihistamines], trazodone) within 14 days prior to Day 1 through completion of the Day 45 visit • Exposure to another investigational medication or device from 30 days prior to screening through completion of the Day 45 visit • Any known strong inhibitors of cytochrome P450 (CYP)3A4 within 14 days or 5 half-lives (whichever is longer) within 14 days prior to receiving the first dose of IP through the 14-day treatment period • Use of any strong CYP3A inducer, such as rifampin, carbamazepine, enzalutamide, mitotane, phenytoin, or St John’s Wort within 14 days or 5 half-lives (whichever is longer) prior to receiving the first dose of IP through the 14-day treatment period • Use of any chronic or as-needed psychostimulants (eg, methylphenidate, amphetamine) or opioids from within 28 days prior to Day 1 through completion of the Day 45 visit
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Prohibited Medications. Medications specifically prohibited in the exclusion criteria are not allowed during the ongoing study (Section 5.2). The list of medications below is not exhaustive. If there are any questions regarding a medication, the investigator can consult with the Sponsor’s Medical Monitor (or designee). The following treatments are prohibited for all subjects during the study: • Phototherapy (PUVA and/or UVB) • All biologic therapy with a potential therapeutic impact on the disease being studied, including but not limited to the following: anakinra (Kineret®), abatacept (Orencia®), adalimumab (Humira®), natalizumab (Tysabri®), ustekinumab (Stelara®), etanercept (Enbrel®), infliximab (Remicade®), rituximab (Rituxan®), tocilizumab (Actemra®), efalizumab (Raptiva®), golimumab (Simponi®), certolizumab (Cimzia®), belimumab (Benlysta®), secukinumab (Cosentyx®) • Any investigational agents • Any oral antibiotic treatment for HS or other systemic non-biologic therapies with potential therapeutic impact on HS, including but not limited to antibiotics, methotrexate, cyclosporine, retinoids, corticosteroids, and fumaric acid esters • Live or live-attenuated vaccines (during the study and for 28 days after the last dose of study treatment) • New use of oral, topical, and opioid analgesics for HS • Prescription topical therapies for the treatment of HS, including topical steroids, calcineurin inhibitors, and phosphodiesterase inhibitors • New use of over-the-counter topical antiseptic washes, creams, soaps, ointments, gels, and liquids containing antibacterial agents to treat HS not listed in
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Prohibited Medications. Known prior medications that exclude a patient from participating in this cohort are described in the exclusion criteria (see Section 8.2). Medications prohibited in the overall study are provided in the master protocol. The following additional therapies are prohibited during the screening and treatment phase for this cohort. • Investigational agents other than TSR-042, bevacizumab, and niraparib • Systemic glucocorticoids for any purpose other than to manage symptoms of suspected irAEIs. (Note: Use of inhaled steroids, local injection of steroids, topical steroids, and steroid eye drops are allowed.) If medically deemed necessary (eg, acute asthma or chronic obstructive pulmonary disease exacerbation, prophylaxis for IV contrast if indicated), Investigators are allowed to use their judgment to treat patients with systemic steroids. In such cases, systemic steroids should be stopped at least 24 hours prior to the next dose of TSR-042. • Prophylactic cytokines (ie, granulocyte colony-stimulating factor [GCSF]) should not be administered in the first cycle of the study but may be administered in subsequent cycles according to current American Society of Clinical Oncology (ASCO) guidelines.39 In addition, niraparib has been shown to weakly induce cytochrome P450 (CYP) 1A2 in vitro and is an insensitive substrate for P-glycoprotein. Therefore, Investigators and patients should be advised to use caution with drugs that are sensitive substrates of CYP1A2 with narrow therapeutic range, such as theophylline and tizanidine. The niraparib safety profile includes risk for thrombocytopenia, and bevacizumab may increase the potential for bleeding (hemorrhage); therefore, patients should be advised to use caution with anticoagulants (eg, warfarin) and antiplatelet drugs (eg, aspirin). Physicians should follow the current versions of the TSR-042 Investigator’s Brochure, the Zejula® package insert39, the Avastin® [Genentech/Roche US] package insert40, and the niraparib Investigator’s Brochure for information on the general management of the patients receiving these therapies.
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Related to Prohibited Medications

  • Prohibited Persons Neither Purchaser, nor any Affiliate of Purchaser nor any Person that directly or indirectly owns 10% or more the outstanding equity in Purchaser (collectively, the “Purchaser Persons”), is, or has been determined by the U.S. Secretary of the Treasury to be acting on behalf of, a Blocked Person, or has otherwise been designated as a Person (i) with whom an entity organized under the laws of the United States is prohibited from entering into transactions or (ii) from whom such an entity is prohibited from receiving money or other property or interests in property, pursuant to the Executive Order or otherwise. In addition, no Purchaser Person is located in, or operating from, a country subject to U.S. economic sanctions administered by OFAC.

  • Prohibited Uses You may use the Website only for lawful purposes and in accordance with these Terms of Use. You agree not to use the Website: • In any way that violates any applicable federal, state, local, or international law or regulation (including, without limitation, any laws regarding the export of data or software to and from the US or other countries). • For the purpose of exploiting, harming, or attempting to exploit or harm minors in any way by exposing them to inappropriate content, asking for personally identifiable information, or otherwise. • To send, knowingly receive, upload, download, use, or re-use any material that does not comply with the Content Standards set out in these Terms of Use. • To transmit, or procure the sending of, any advertising or promotional material without our prior written consent, including any "junk mail," "chain letter," "spam," or any other similar solicitation. • To impersonate or attempt to impersonate the Company, a Company employee, another user, or any other person or entity (including, without limitation, by using email addresses or screen names associated with any of the foregoing). • To engage in any other conduct that restricts or inhibits anyone's use or enjoyment of the Website, or which, as determined by us, may harm the Company or users of the Website, or expose them to liability. Additionally, you agree not to: • Use the Website in any manner that could disable, overburden, damage, or impair the site or interfere with any other party's use of the Website, including their ability to engage in real time activities through the Website. • Use any robot, spider, or other automatic device, process, or means to access the Website for any purpose, including monitoring or copying any of the material on the Website. • Use any manual process to monitor or copy any of the material on the Website, or for any other purpose not expressly authorized in these Terms of Use, without our prior written consent. • Use any device, software, or routine that interferes with the proper working of the Website. • Introduce any viruses, Trojan horses, worms, logic bombs, or other material that is malicious or technologically harmful. • Attempt to gain unauthorized access to, interfere with, damage, or disrupt any parts of the Website, the server on which the Website is stored, or any server, computer, or database connected to the Website. • Attack the Website via a denial-of-service attack or a distributed denial-of-service attack. • Otherwise attempt to interfere with the proper working of the Website.

  • Prohibited Use 4. You may not use the Website for any of the following purposes:

  • Prohibited Person New Borrower warrants and represents, after review of the website identified below, that neither New Borrower nor Principal nor any of their respective officers or directors is an entity or person (i) that is listed in the Annex to, or is otherwise subject to the provisions of, Executive Order 13224, issued on September 24, 2001 (“EO13224“), (ii) whose name appears on the United States Treasury Department’s Office of Foreign Assets Control (“OFAC“) most current list of “Specifically Designated Nationals and Blocked Persons“ (which list may be published from time to time in various media including but not limited to, the OFAC website, hxxx://xxx.xxxxx.xxx/xxxxxxx/enforcement/ofac/sdn/t11sdn.pdf, (iii) who commits, threatens to commit or supports “terrorism“, as that term is defined in EO13224, or (iv) who, to the knowledge of New Borrower, is otherwise affiliated with any entity or person listed above (any and all parties or persons described in clauses [i] – [iv] above are herein referred to as a “Prohibited Person“). New Borrower covenants and agrees that neither New Borrower nor Principal nor any of their respective officers or directors will (a) knowingly conduct any business, or engage in any transaction or dealing, with any Prohibited Person, including, but not limited to, the making or receiving of any contribution of funds, goods, or services, to or for the benefit of a Prohibited Person, or (b) knowingly engage in or conspire to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding, or attempts to violate, any of the prohibitions set forth in EO13224. New Borrower further covenants and agrees to deliver (from time to time) to Lender any such certification as may be requested by Lender in its reasonable discretion, confirming that, based on reasonable inquiry (x) neither New Borrower nor Principal nor any of their respective officers or directors is a Prohibited Person and (y) neither New Borrower nor Principal nor any of their respective officers or directors has (a) knowingly conducted any business, or engaged in any transaction or dealing, with any Prohibited Person, including, but not limited to, the making or receiving of any contribution of funds, goods, or services, to or for the benefit of a Prohibited Person or (b) knowingly engaged in or conspired to engage in any transaction that evaded or avoided, or had the purpose of evading or avoiding, or attempted to violate, any of the prohibitions set forth in EO13224.

  • Prohibited Contracts Other than those listed on Schedule 7.11:

  • Prohibited Activities You may not access or use the Site for any purpose other than that for which we make the Site available. The Site may not be used in connection with any commercial endeavors except those that are specifically endorsed or approved by us. As a user of the Site, you agree not to:

  • Prohibited Actions The Company agrees that it will not take any action which would entitle the Warrantholder to an adjustment of the Exercise Price if the total number of shares of Common Stock issuable after such action upon exercise of this Warrant, together with all shares of Common Stock then outstanding and all shares of Common Stock then issuable upon the exercise of all outstanding options, warrants, conversion and other rights, would exceed the total number of shares of Common Stock then authorized by its Charter.

  • No Prohibited Persons Neither Seller nor any of its Affiliates, officers, directors, partners or members, is an entity or person (or to Seller’s knowledge, owned or controlled by an entity or person): (i) that is listed in the Annex to, or is otherwise subject to the provisions of Executive Order 13224 issued on September 24, 2001 (“EO13224”); (ii) whose name appears on the United States Treasury Department’s Office of Foreign Assets Control (“OFAC”) most current list of “Specifically Designated National and Blocked Persons” (which list may be published from time to time in various mediums including, but not limited to, the OFAC website, http:xxx.xxxxx.xxx/xxxx/x00xxx.xxx); (iii) who commits, threatens to commit or supports “terrorism”, as that term is defined in EO13224; or (iv) who is otherwise affiliated with any entity or person listed above (any and all parties or persons described in clauses (i) through (iv) above are herein referred to as a “Prohibited Person”).

  • Prohibited Conduct In providing the services described in this agreement, the Sub-Advisor will not consult with any other investment advisory firm that provides investment advisory services to any investment company sponsored by Principal Life Insurance Company regarding transactions for the Fund in securities or other assets.

  • Certain Prohibited Transfers The Shareholder agrees not to, except as provided for in this Agreement or the Merger Agreement:

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