Quantification of enamel and dentine shrinkage errors Sample Clauses

Quantification of enamel and dentine shrinkage errors. In order to assess the effect of partial dehydration on the dimension stability of worn enamel and dentine, enamel and dentine samples were firstly prepared as described below. In line with UK legislation (Human Tissue Act, 2004) and guidelines (Good practice in research and consent to research, 2010; HTA Codes of Practice, 2009) regulating activities concerning the removal, storage, use and disposal of human tissue in the UK, teeth were sourced for use in the studies that form Chapters 3, 4 and 5 of this thesis. In order to achieve this, ethical approval for the research was sought from a local research ethics committee (King’s College Hospital NHS Foundation Trust Research Ethics Committee Approval reference 09/H0808/109). Once granted, Research and Development approval was sought from both King’s College Hospital NHS Foundation Trust (where the teeth were donated) and from Guy’s and St. Xxxxxx’ NHS Foundation Trust (where the laboratory work was carried out). Once this was granted a Material Transfer Agreement between the two NHS partner sites (King’s College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS and Guy’s and St.Xxxxxx’ NHS Foundation Trust, Great Maze Pond, London, SE1 9RT) was sought in order to safely transfer the human tissue approximately 3.2 miles across South-East London. In order to source suitable teeth for the research, potential subjects for tooth donation were sought from patients attending for an assessment appointment at the Oral Surgery Department at King's College Hospital NHS Foundation Trust, prior to undergoing routine extractions of their third molars (required for the enamel and dentine samples in these studies) or premolars (required for the enamel attrition antagonists in these studies). Those patients who needed one or more of their teeth extracted were invited to participate in the study by the clinician from the oral surgery department who was taking first stage clinical consent at this assessment appointment. All clinicians who were identifying potential subjects had been provided with information and training by the research team in order to ensure that the clinicians could identify suitable subjects (according to the principle inclusion and exclusion criteria for recruitment of participants to donate extracted teeth for the research study ‘Protection of erosive wear’ as shown in Table 4 below) and to ensure that the clinicians were familiar with the proposed research work so that they would be able to...