Recruitment and Subject Population Clause Samples

Recruitment and Subject Population. Subjects may be men or women aged 18 or older with a confirmed diagnosis of chronic, treatment-resistant PTSD who have undergone psychotherapeutic or psychopharmacological treatment for PTSD of adequate dose/duration without achieving remission. Subjects who discontinued PTSD treatment due to inability to tolerate psychotherapy (e.g. due to persistent “over-engagement”) or psychopharmacology due to treatment-emergent side effects would not be excluded. Subjects would also not be excluded for having more than one traumatic event. Subjects must have a CAPS score equal to or greater than 50 and must meet all inclusion criteria and no exclusion criteria at baseline. They must be in good physical health and without major medical disorders that might affect the safety or tolerability of MDMA. Subjects will be recruited through printed ads, internet ads, referrals from other psychiatrists, psychotherapists or physicians, and through word of mouth. Twelve participants who meet all inclusion criteria without meeting any exclusion criteria will be admitted to the study. Only IRB- approved recruitment materials and advertisements will be used for the study.