Heart. (a) Is there any cardiovascular disorder? [_] Yes [_] No (b) Is heart enlarged? [_] Yes [_] No (If yes, describe) (c) Is murmur present? [_] Yes [_] No (If yes, complete 15d) ------------------------------------------------------------------- (d) Murmur is: [_] Constant [_] Inconstant [_] Transmitted [_] Systolic [_] Apical [_] Soft (Gr. 1-2) [_] Localized [_] Presystolic [_] Basal [_] Mod. (Gr. 3-4) [_] Diastolic [_] Other [_] Loud (Gr. 5-6) After exercise [_] Unchanged [_] Increased [_] Decreased [_] Absent Show location of: Apex by [SYMBOL] Area of murmur by [SYMBOL] [GRAPHIC APPEARS HERE] Point of greatest intensity by [SYMBOL] Transmission by [SYMBOL]
Heart. A variable of a subrange type has all the properties of variables of the host type, but its run-time value must be in the specified interval. One syntactic ambiguity arises from allowing constant expressions where Standard Xxxxxx only allows simple constants. Consider the following declarations: const X = 50; Y = 10; type Color = (Red, Green, Blue); Scale = (X - Y) * 2..(X + Y) * 2; Standard Pascal syntax dictates that, if a type definition starts with a parenthesis, it’s an enumerated type, such as the Color type in the previous example. The intent of the declaration of scale is to define a subrange type, however. The solution is to reorganize the first subrange expression so that it doesn’t start with a parenthesis, or to set another constant equal to the value of the expression and use that constant in the type definition: type Scale = 2 * (X - Y)..(X + Y) * 2; Real types A real type has a set of values that is a subset of real numbers, which can be represented in floating-point notation with a fixed number of digits. A value’s floating-point notation normally comprises three values—M, B, and E—such that M x BE = N, where B is always 2, and both M and E are integral values within the real type’s range. These M and E values further prescribe the real type’s range and precision. There are five kinds of real types: Real, Single, Double, Extended, and Comp. The real types differ in the range and precision of values they hold as shown in the following table: Table 3-4 Real data types Type Range Significant digits Size in bytes Real 2.9 x 10-39 .. 1.7 x 1038 11-12 6 Single 1.5 x 10-45 .. 3.4 x 1038 7-8 4 Double 5.0 x 10-324 .. 1.7 x 10308 15-16 8 Extended 3.4 x 10-4932 .. 1.1 x 104932 19-20 10 Comp -263+1 .. 263 -1 19-20 8 The Comp type holds only integral values within -263+1 to 263 -1, which is approximately -9.2 x 1018 to 9.2 x 1018. Object Pascal supports two models of code generation for performing real-type operations: software floating point and 80x87 floating point. The $N compiler directive is used to select the appropriate model. 80x87 floating point In the {$N+} state, which is selected by default, the generated code performs all real- type calculations using 80x87 instructions and can use all five real types. For more details on 80x87 floating-point code generation, refer to Chapter 14, “Using the 80x87.” Software floating point In the {$N-} state, the generated code performs all real-type calculations in software by calling run-time library ro...
Heart failure HF is a life-threatening chronic disease that prevents the heart from pumping sufficient levels of blood around the body. HF affects approximately 64 million people worldwide. HF remains as fatal as some of the most common cancers in both men (prostate and bladder cancers) and women (breast cancer).3 Chronic HF is the leading cause of hospitalisation for those over the age of 65 and represents a significant clinical and economic burden.4 AstraZeneca's ambition is to be the leading company in HF. AstraZeneca is investing in multiple investigational therapies with diverse mechanisms of action to address the spectrum of patient need in this area. ATTR-CM Cardiomyopathy due to ATTR is caused by aging or genetic mutations resulting in misfolded TTR protein and accumulation as amyloid fibrils in the cardiac myocardium. In patients with ATTR-CM, both the mutant and wild type TTR protein builds up as fibrils in tissues, including the heart. The presence of TTR fibrils interferes with the normal functions of these tissues. As the TTR protein fibrils enlarge, more tissue damage occurs and the disease worsens, resulting in poor quality of life and eventually death. Worldwide, there are an estimated 300,000-500,000 patients with ATTR-CM5,6; however, many of those patients remain undiagnosed. NI006 NI006 is an investigational human monoclonal antibody that specifically targets misfolded transthyretin and is designed to directly address the pathology of ATTR-CM by enabling removal of amyloid fibril deposits in the heart, with the potential to treat patients with advanced ATTR-CM. Xxxxxxx Xxxxxxx, AstraZeneca Rare Disease, is the group within AstraZeneca focused on rare diseases, created following the 2021 acquisition of Alexion Pharmaceuticals, Inc. As a leader in rare diseases for nearly 30 years, Alexion is focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialisation of life-changing medicines. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on haematology, nephrology, neurology, metabolic disorders, cardiology and ophthalmology. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. AstraZeneca
Heart. (2) Liver;
Heart. Coronary artery bypass graft surgery 冠 狀 動 脈 搭 橋 手 術 Complex 複 雜 PTCA with stent insertion 經 皮 穿 冠 狀 動 脈 血 管 成 形 術 及 支 架 內 置 術 Complex 複 雜 PTCA without stent insertion 經 皮 穿 冠 狀 動 脈 血 管 成 形 術 （ 不 設 支 架 ） Major 大 Cardiac catheterisation (including coronary arteriography) 心 導 管 插 入 術 （ 包 括 冠 狀 動 脈 造 影 術 ） Major 大 Thyroid gland 甲狀腺 Total thyroidectomy 甲 狀 腺 完 全 切 除 術 Major 大 Bilateral subtotal thyroidectomy 雙 側 甲 狀 腺 次 全 （ 亞 全 ） 切 除 術 Major 大 Hemi-thyroidectomy 甲 狀 腺 單 側 切 除 術 Major 大 Fine needle aspiration (FNA) / biopsy of thyroid gland 針 取 甲 狀 腺 細 胞 手 術 / 甲 狀 腺 活 組 織 檢 查 Day Case 日 症 手 術 Minor 小 乳房 Breast Partial / total mastectomy with axillary dissection / radical mastectomy Major 大 乳 房 部 份 / 完 全 切 除 術 並 包 括 腋 下 淋 巴 切 除 手 術 / 根 治 性 乳 房 切 除 術 Lumpectomy or partial / total mastectomy with / without biopsy of sentinel lymph node Intermediate 中 乳 房 腫 瘤 切 除 術 或 部 份 / 完 全 乳 房 切 除 術 （ 包 括 或 不 包 括 前 哨 淋 巴 腺 活 組 織 檢 查 ） Incision and drainage of breast abscess 乳 房 膿 腫 切 開 及 引 流 Minor 小 Percutaneous fine needle biopsy of lesion of breast with / without ultrasound guided Day Case 日 症 手 術 Minor 小 乳 房 病 變 經 皮 針 吸 活 組 織 檢 查 （ 包 括 或 不 包 括 超 聲 波 檢 查 ） 眼部
Heart. HET shall conduct a onsite or virtual workshop for the faculty, to inspire them to teach in a reflective manner and also to help them integrate meditative aspects to their course design.
Heart. Blood pressure and pulse rate: We check for higher-than-normal blood pressure (hypertension) as this means that the heart has to work harder to push blood around your body. Over the long term, this is associated with an increased risk of heart attack, stroke and kidney failure Body composition Height and weight measurement: We combine and compare these measurements with other tests. Body Max Index (BMI): This is a ratio of your height to weight, which helps to indicate if you are at a healthy weight. People with a BMI of 25 and over can have a higher-than-average risk of health problems like diabetes, heart disease and some cancers. Blood tests Cholesterol profile blood test: (including LDL and HDL) High cholesterol affects your heart and blood vessels and increases your risk of developing cardiovascular disease. Diabetes blood test: We check for raised glucose levels which may indicate diabetes. This can usually be controlled with diet, exercise or medicines. If not controlled, it can increase the risk of problems such as heart disease and strokes, nerve damage and blindness. Health Risks Coronary heart disease risk score: We estimate the risk of a heart attack within the next 10 years, taking into account your age, sex, total cholesterol, High-Density Lipoprotein (HDL) cholesterol, blood pressure, presence of diabetes and whether or not you smoke The Supplier also has a range of other tests, checks and services which can be provided to the Commissioner’s staff either at the Commissioner’s or individual staff member’s expense. Separate billing for additional items can be arranged directly with the Commissioner’s staff. The Supplier either owns or has a partnership arrangement with other organisations which enable it to provide satisfactory facilities for the medical assessments to take place which are within reasonably close proximity to each of the Commissioner’s offices and accessible via public transport or have on-site parking. Each facility has comfortable waiting areas with refreshments, changing rooms and toilet facilities and private and fully equipped assessment rooms. As the majority of the Commissioner’s staff are based in Wilmslow it is anticipated that most assessments will take place at either the Supplier’s Central Manchester or Macclesfield facilities. All assessment centres to be used in provision of the Services are regulated by the Care Quality Commission. All processes and procedures are accredited to ISO standard 9001:2008. The Suppli...
Heart. Coronary artery bypass graft surgery Complex PTCA with stent insertion Complex PTCA without stent insertion Major Cardiac catheterisation (including coronary arteriography) Major Thyroid gland Total thyroidectomy Major Bilateral subtotal thyroidectomy Major Hemi-thyroidectomy Major Fine needle aspiration (FNA) / biopsy of thyroid gland / Day Case Minor Breast Partial / total mastectomy with axillary dissection / radical mastectomy Major / / Lumpectomy or partial / total mastectomy with / without biopsy of sentinel lymph node Intermediate / Incision and drainage of breast abscess Minor Percutaneous fine needle biopsy of lesion of breast with / without ultrasound guided Day Case Minor 乳房病變經皮針吸活組織檢查（包括或不包括超聲波檢查）
Heart. Coronary artery disease Hypertension Murmurs Valvular disease Aneurysm High Cholesterol Lungs: Asthma COPD Emphysema Bronchitis TB Pneumonia Lung Cancer Other: Gastrointestinal: Ulcer Reflux Gastritis Hepatitis Cancer Bleeding Diverticulosis Other: Kidney: Failure Stones Dialysis (When): Other: Endocrine: Diabetes Hypothyroidism Hyperthyroidism Other: Neuro: Stroke Aneurysm Brain cancer Nerve injury Spinal cord injury Alzheimer’s Dementia Seizures Xxxxxxxxx’x Other: Psychiatric: Depression Bipolar Anxiety Panic disorder Psychosis Schizophrenia Other: Bone/Muscular: Arthritis Rheumatoid arthritis Osteoarthritis Gout Osteoporosis Scoliosis Cancer: Other:
Heart. Mice were anaesthetised with isoflurane, and exsanguination was achieved by drawing blood from the abdominal IVC. The rib cage was then opened to reveal the heart. The heart was perfused with 1ml cold sterile saline through the aorta and removed from the animal. The heart was placed in a 40mm petri dish and sliced in half using a blade. Any remaining blood was flushed from the ventricles using saline, and the tissue placed in a fresh petri dish containing 1ml heart digestion media. The tissue was minced to 1mm pieces using microscissors and transferred to a 5ml polypropylene tube, which was placed on ice. Xxxxxx was allowed to settle at the bottom of the tube and supernatant aspirated to a 50ml Falcon tube with 100µm nylon mesh attached. The mesh was washed with heart digestion media, and the tube placed on ice. To the heart tissue, 1ml digestion mix (heart digestion media plus 10µg/ml type 1 collagenase (Sigma-Xxxxxxx; Merck KGaA) and 10µg/ml DNAse 1) pre-warmed to 37ºC was added, and the tube incubated at 37ºC for 15 minutes. The tube was vortexed for 1 minute half way through the incubation. This process was repeated, and after the final incubation the remaining undigested tissue was mashed through a 100µm nylon mesh with the plunger of a 1ml syringe. The tube containing the digested heart tissue was centrifuged at 1100RPM for 5 minutes at 4ºC. The supernatant was discarded and the tissue re-suspended in 3ml 0.01M EDTA in FCS at room temperature. The suspension was then layered over 3ml Histopaque-1077 (Sigma-Xxxxxxx; Merck KGaA) at room temperature, and centrifuged for 30 minutes at 900RPM at room temperature with no brake. Leukocytes form an opaque layer between the Histopaque-1077 and the FCS. Due to low yields of leukocytes from heart tissue, the FCS and leukocyte layer were carefully removed to a 15ml Falcon tube and topped up to 10ml with PBS. The tube was spun at 1100RPM for 10 minutes at 4ºC. The supernatant was discarded and the heart leukocytes were re-suspended in FACS buffer.
