Trajectory Analysis Sample Clauses

Trajectory Analysis. The U.S. signatories will provide for a preliminary and a final Trajectory Analysis which will include sequence of events, vacuum impact point prediction, tracking information, and insertion accuracy as well as range safety parameter and lines of sight for down-range acquisition. A summary of the results of these analyses will be presented to the foreign signatories at the appropriate PMR, ICWG, and Progress Reviews.
Trajectory Analysis. If the FRET efficiency time traces display temporal fluctuations, the data can be further analyzed to obtain more detailed information on the kinetics of the system using dwell-time analysis or hidden Markov modeling, depending on the type of fluctuation as described below. Regardless of the method of trajectory analysis, only molecules exhibiting single-step photobleaching are analyzed, as this is a unique signature of a FRET interaction between a single donor and single acceptor molecule (Figure 2.7C). i. Dwell-time analysis ii. Hidden Markov Modeling Excited States (1) hv (2) hv (3) (1) Excitation of a fluorophore occurs through the absorption of light energy. (2) During the transient excited state lifetime, there is some loss of energy as the fluorophore relaxes to the lowest excited state. (3) Return of a fluorophore to its ground state accompanied by the emission of light. The light energy is always of a longer wavelength than the light energy absorbed (the fluorescence emission is shifted towards the red end of the visible spectrum) due to the energy lost during the transient excited state lifetime. Excitation Maxima Emission Maxima Generalized representation of the absorbance and emission spectra of a fluorophore. hv1 (A) A donor fluorophore is directly excited by a light source (green line, hv), causing it to transition to an excited state. After relaxation, the fluorophore can either return to the ground state by emitting a photon (hv1) or nonradiatively transfer energy to a nearby acceptor fluorophore. The nonradiative energy causes the acceptor fluorophore to reach an excited state, and after relaxation during the excited state lifetime, the fluorophore emits a photon (hv2), allowing it to return to its ground state. (B) FRET efficiency is plotted as a function of distance R between the donor and acceptor (blue line). When the distance between the fluorophores attached to a biomolecule is small, the efficiency of energy transfer is high (high FRET), but when the distance between the fluorophores is large, the efficiency of energy transfer is low (low FRET) (green ball, donor; red ball, acceptor; black squiggle, biomolecule). glucose + O2 + H2O H2O2 gluconic acid + ▇▇▇▇ ▇▇▇ + ½ O2
Trajectory Analysis. ‌ The endpoints, MH and QLQ, were treated as continuous variables and unsupervised trajectory clustering was performed by means of a modified k-means algorithm. Specifically, the kmlShape R package was used to cluster individual patient trajectories accounting for the shape of each trajectory using a shape-respecting distance metric. Options regarding the random initialization points and expectation–maximization were kept as default, while the time-slice was set to 0.01. Overall, kmlShape is a variant of k-means where the Fréchet distance, associated with trajectory shape, is used as the distance metric. The Fréchet distance is defined on a continuous interval, so that the real Fréchet distance cannot be obtained in discrete cases, but can be infinitely approximated. In brief, a curve P can be regarded as the mobile trajectory that travels at a speed α. Then, the Fréchet distance between the curve P and another Q considered as a mobile trajectory with speed β, is the smallest possible maximum distance between the two curves after reparameterization of P and Q by α and β, respectively: DistFrechet(P, Q) = dα,β(P, Q). With appropriate approximation, this distance can account for the different number or location of measurement points and missing values in patients. In the implementation of kmlShape, Fréchet distance is also used to determine the cluster centers. A known limitation of k-means algorithm is that the resulting clusters depend on the initial random assignments and, thus, each run with the same number of clusters k, might yield slightly different results. To mitigate this dependence, for each k value, we run the algorithm 10 times with different initial values so as to pick the best result in terms of within-cluster compactness. This was defined as the clustering solution with the lowest within-cluster sum of squares (WSS). The WSS is a commonly used measure of cluster compactness and is defined as the sum of distances between the points and the corresponding centroids for each cluster:

Related to Trajectory Analysis

  • Risk Analysis The Custodian will provide the Fund with a Risk Analysis with respect to Securities Depositories operating in the countries listed in Appendix B. If the Custodian is unable to provide a Risk Analysis with respect to a particular Securities Depository, it will notify the Fund. If a new Securities Depository commences operation in one of the Appendix B countries, the Custodian will provide the Fund with a Risk Analysis in a reasonably practicable time after such Securities Depository becomes operational. If a new country is added to Appendix B, the Custodian will provide the Fund with a Risk Analysis with respect to each Securities Depository in that country within a reasonably practicable time after the addition of the country to Appendix B.

  • Sampling and Analysis The sampling and analysis of the coal delivered hereunder shall be performed by Buyer upon delivery of the coal to Buyer’s facility, and the results thereof shall be accepted and used as defining the quality and characteristics of the coal delivered under this Agreement and as the Payment Analysis. All analyses shall be made in Buyer’s laboratory at Buyer’s expense in accordance with ASTM standards where applicable, or industry-accepted standards in other cases. Samples for analyses shall be taken in accordance with ASTM standards or other methods mutually acceptable to both parties. Seller shall transmit its “as loaded” quality analysis to Buyer as soon as possible. Seller’s “as-loaded” quality shall be the Payment Analysis only when Buyer’s sampler and/or scales are inoperable, or if Buyer fails to obtain a sample upon unloading. Seller represents that it is familiar with Buyer’s sampling and analysis practices, and that it finds them to be acceptable. Buyer shall notify Seller in writing of any significant changes in Buyer’s sampling and analysis practices. Any such changes in Buyer’s sampling and analysis practices shall, except for ASTM or industry-accepted changes in practices, provide for no less accuracy than the sampling and analysis practices existing at the tune of the execution of this Agreement, unless the Parties otherwise mutually agree. Each sample taken by Buyer shall be divided into four (4) parts and put into airtight containers, properly labeled and sealed. One (1) part shall be used for analysis by Buyer. One (1) part shall be used by Buyer as a check sample, if Buyer in its sole judgment determines it is necessary. One (1) part shall be retained by Buyer until thirty (30) days after the sample is taken (“Disposal Date”), and shall be delivered to Seller for analysis if Seller so requests before the Disposal Date. One (1) part (the “Referee Sample”) shall be retained by Buyer until the Disposal Date. Seller shall be given copies of all analyses made by Buyer by the fifth (5th) business day of the month following the month of unloading. In addition, Buyer shall send Seller weekly analyses of coal unloaded at Buyer’s facilities. Seller, on reasonable notice to Buyer, shall have the right to have a representative present to observe the sampling and analyses performed by Buyer. Unless Seller requests an analysis of the Referee Sample before the Disposal Date, Buyer’s analysis shall be used to determine the quality of the coal delivered hereunder and shall be the Payment Analysis. The Monthly Weighted Averages of specifications referenced in §6.1 shall be based on the individual Shipment analyses. If any dispute arises with regard to the analysis of any sample before the Disposal Date for such sample, the Referee Sample retained by Buyer shall be submitted for analysis to an independent commercial testing laboratory (“Independent Lab”) mutually chosen by Buyer and Seller. For each coal quality specification in question, if the analysis of the Independent Lab differs by more than the applicable ASTM reproducibility standards, the Independent Lab results will govern, and the prior analysis shall be disregarded. All testing of the Referee Sample by the Independent Lab shall be at requestor’s expense unless the Independent Lab results differ from the original Payment Analysis for any specification by more than the applicable ASTM reproducibility standards as to that specification. In such case, the cost of the analysis made by the Independent Lab shall be borne by the party who provided the original Payment Analysis.

  • Quantitative Analysis Quantitative analysts develop and apply financial models designed to enable equity portfolio managers and fundamental analysts to screen potential and current investments, assess relative risk and enhance performance relative to benchmarks and peers. To the extent that such services are to be provided with respect to any Account which is a registered investment company, Categories 3, 4 and 5 above shall be treated as “investment advisory services” for purposes of Section 5(b) of the Agreement.”

  • Research Analyst Independence The Company acknowledges that the Underwriters’ research analysts and research departments are required to be independent from their respective investment banking divisions and are subject to certain regulations and internal policies, and that such Underwriters’ research analysts may hold views and make statements or investment recommendations and/or publish research reports with respect to the Company and/or the offering that differ from the views of their respective investment banking divisions. The Company hereby waives and releases, to the fullest extent permitted by law, any claims that the Company may have against the Underwriters with respect to any conflict of interest that may arise from the fact that the views expressed by their independent research analysts and research departments may be different from or inconsistent with the views or advice communicated to the Company by such Underwriters’ investment banking divisions. The Company acknowledges that each of the Underwriters is a full service securities firm and as such from time to time, subject to applicable securities laws, may effect transactions for its own account or the account of its customers and hold long or short positions in debt or equity securities of the companies that may be the subject of the transactions contemplated by this Agreement.

  • SAMPLE (If applicable and the project has specifications, insert the specifications into this section.)