Conclusions. The Independent Directors, taking note (i) of the statements by the Offeror contained in the Offer- ing Document; (ii) the conclusions stated in the Fairness Opinion; and (iii) that, to the best of their knowledge, on the date on which this Opinion is being prepared and issued, no elements have emerged that contrast the abovementioned conclusions by the Independent Expert and their shared endorsement, including in light of all the considerations described in the Opinion – what is already indicated in Article 2 above – believe unanimously that: the PTO is consistent with the provisions of the legal regime for mandatory PTOs, not containing accessory or incidental elements that would influence its essential content; the Consideration for the PTO – greater than the maximum value in the range indicated by the Independent Expert with reference to each valuation method and criterion used – may be deemed appropriate. Milan, 29 July 2016 Signed by Xxxxxx Xxxxxxxx (Lead Indipendent Director); Xxxxx Xxxxxxx; Xxxxxxxx xx Xxxxx- xxx; Xxxxxxx Xxxxxx Xxxxxxx; Xxxxx Xxxxxxxx- ni; Xxxxxxx Xxxxx; Xxxxx Xxxxxx.
Conclusions. According to the objectives of this activity, we have developed and described a methodology to address the design of RF-based plasma thrusters. We consider a three-stage thruster with magnetic transversal confinement. It is composed of a generation unit, a helicon plasma source; a booster section employ- ing radio frequency (RF) power at the ion cyclotron (IC) frequency (ion-cyclotron resonant "heating", ICRH); and finally a magnetic nozzle. Our approach relies on both the self-consistent TOPICA code for modeling the RF behavior of the ICRH antenna, and a fast zero-dimensional numerical model purposefully developed for the global description of the plasma-device. TOPICA has been modified to handle the specific geometry and plasma of the thruster; it allows the evaluation of the ICRH antenna parameters (strictly related to the an- xxxxx shape and plasma composition) and the ensuing radiated power. The zero- dimensional global model provides the relevant global system parameters, neces- sary to assess the engine performance. TOPICA results for the parameters of the ICRH antenna of the booster unit were validated against published measured data (for the so-called coupling resis- tance). The predictions of the global modelling were likewise validated against published experimental values. The developed tool set as a whole can be used, for instance, to investigate the feasibility of a low-power (a few kW) system and then to address its scaling to high power. Because of the reduced computational load of the zero-dimensional model, evolutionary algorithms can be employed to optimize the model. With this approach, optimal values of power partition, mass flow rate, type of propellant, magnetic field and dimensions of the thruster have been be computed as an example. The results of the model give the indication of the values of plasma pa- rameters that should be expected during the experiment, and also the requirements for the needed diagnostics. In this respect, the carried out prototypical optimization exercise confirms that the use of Argon as propellant is preferable to other lighter gases, mainly because it can be ionized with significantly lower power. [1] X. Xxxxxxxxxxx, X. Xxxxxxxxx, X. Xxxxxxxx, X. Xxxxxx, X. Kyrytsya 2006 Nucl. Fusion 46 S476 [2] F. R. Xxxxx-Xxxx 2000 Sci. Am. 283 90 [3] I. V. Xxxxxxx 1992 Methods for Electromagnetic Field Analysis Oxford Engi- neering Science Series (Oxford: Clarendon Press) [4] X. X. Xxxxxxxx, X. X. Xxx, X. Xxxxxx 1998 C...
Conclusions. The view on Employment Protection Legislation effects on labour market will always be the playing field of political debates and of the subsequent economic policies.
Conclusions. In human platelets, GLP-1, independently of GLP- 1R, reduces the NaA-induced activation of PI3K and MAPK path- ways and of oxidative stress. Because MAPK activation is involved in the NaA-induced increase of oxidative stress, the inhibiting ef- fects of GLP-1 on MAPK activation can account for its ability to attenuate the NaA-induced increase of oxidative stress. STUDY OF LYSOSOMIAL ACID LIPASE ACTIVITY AND ITS DETERMINANTS IN ADULT PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE: PRELIMINARY RESULTS Introduction and aims. Nonalcoholic fatty liver disease (NA- FLD), the most common hepatic disease, includes a wide spectrum of liver diseases ranging from simple steatosis to non-alcoholic
Conclusions. In FH-patients the development of atherosclerosis is accelerated despite intensive lipid-lowering treatment. To obtain a further reduction of atherosclerosis burden an earlier onset as well as a more aggressive therapy is highly advisable.
Conclusions. In the postprandial phase HOMA index positively correlated with the ω3/ω6 ratio at time 210 minutes and 240 min- utes in NAFLD patients and QUICKI index was inversely correlat- ed with the ω3/ω6 ratio at 210 minutes. Amount and type of dietary fatty acids influence postprandial response. An imbalance in the ω3/ω6 fatty acids ratio could modulate postprandial responses with more pronounced effects in insulin-resistant subjects, such as NAFLD patients. K. Garlaschelli1, F. Pellegatta1, X. Baragetti1,2, L. Grigore1, A. Pirillo1,3, A.L. Catapano2,3 1Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Xxxxxxx, Xxxxx; 2Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan; 3IRCCS MultiMedica, Sesto San Giovanni, Milan E-mail: xxxxxxxxxxxx.xxxxxxxxxxx@xxxxx.xxx Familial hypercholesterolemia (FH) is a genetic disease mainly due to autosomic dominant mutations in several genes involved in the control of low density lipoprotein cholesterol (LDL-C) lev- els, including the low density lipoprotein receptor (LDLR), apoli- poprotein B (apoB), proprotein convertase subtilisin/kexin type 9 (PCSK9). An autosomal recessive form of FH, due to loss-of-func- tion mutation in the LDLR adaptor protein 1 (LDLRAP1) gene, has also been described. A high number of genetic variants for the LDLR gene that co-segregate with hypercholesterolemia have been reported. Subjects with high levels of LDL-C and a history of personal or fa- milial premature CAD were evaluated according to the MEDPED score, to define the presence of genetic defects in one of the known candidate genes. We have identified two families with mutations not yet described. The first proband is a 31-year-old man with high levels of total and LDL-C (364 and 291 mg/dL, respectively) and a history of familial hypercholesterolemia and premature CAD. The genetic analysis identified the mutation c.1207 -1209delTTC (p.Phe403del) in the exon 9 of LDLR. The two proband’s children were carriers of the same variant,and were both hypercholesterol- emic. The second proband is a 55-year-old man with high levels of total and LDL-C (460 and 397 mg/dL, respectively) and a prema- ture myocardial infarction at age 42. The genetic analysis identi- fied a splice site mutation (c.1061-1G>T) in intron 7 of LDLR, a vari- ant with a very high splicing prediction. His son, which exhibited high levels of total and LDL-C (321 and 258 mg/dL, respectively), carries the same genetic variant. I...
Conclusions. In hypertensive AF patients, subclinical atheroscle- rosis, assessed by cIMT, is associated with previous cardiovascu- lar and cerebrovascular events, smoking and persistent/perma- nent AF. Statin and β blockers use seems to have a favorable effect on carotid atherosclerosis.
Conclusions. In our population we found a mutation frequency of about 25%, confirming that the LPL gene is the most frequently mutated in HTG. The high heterogeneity of the HTG and the in- complete knowledge of the genetic of this disease recommended a deep genetic screening for the identification of new variants. STAT3 INHIBITION INDUCES PCSK9 IN HEPATIC CELL LINE: POSSIBLE INVOLVEMENT IN HYPERTRIGLYCERIDEMIA ASSOCIATED WITH INSULIN RESISTANCE EVALUATION OF AGREEMENT AMONG CARDIOVASCULAR RISK CALCULATORS AND THEIR CORRELATION WITH ARTERIAL STIFFNESS IN CLINICAL PRACTICE Background. Evaluation of global cardiovascular risk using car- diovascular disease risk calculators is usually recommended by the main guidelines for cardiovascular prevention. Differences in risk estimation could results in changes in clinical management of the patients, but evidence on the consistency in risk assessment among different calculators and their correlation with marker of arterial stiffness are still far to be fully elucidated.
Conclusions. It is hard to understand the enthusiasm shown by the agricultural sector and the attention that the proposal and subsequent adoption of the Directive have constantly received, including from the media. Fortunately, Parliament’s intervention during the procedure for the adoption of the act has significantly broadened the subjective and objective scope of the new rules and included many types of unfair practices that the Commission proposal did not cover at all. In fact, the Directive cannot be considered as a general instrument for combating unfair commercial practices in the agri-food chain, but rather as an instrument for combating only certain practices, and in particular well- identified cases. Moreover, for six of these practices, the prohibition is not absolute, deriving from the fact that they are not clearly and unequivocally provided in the contract. The practices listed, moreover, cannot be said to be always prohibited even when falling within the ‘black list’ of Article 3(1), since for the prohibition being applicable it is necessary that the undertakings involved in the commercial relationship at issue fall within the turnout thresholds laid down in the Directive: in particular, practices adopted if the contracting undertakings are both micro-enterprises are never prohibited. nor can the directive be considered as a specific safeguard for the agricultural sector, since, as we have seen, its provisions also benefit food businesses, whether they are producing or merely marketing. This admittedly minimalist approach is not surprising, given that the Commission was essentially forced by the Parliament and the Council to adopt a proposal that was not in its wheelhouse and that, in any case, this is the first regulatory intervention: as such, it is susceptible to subsequent amendments, also on the basis of the ex post evaluation that will be made four years after its application. The amendments made by Parliament have, in any case, undoubtedly made this minimal form of intervention to protect the weaker party more effective. There is no doubt, therefore, that despite the harmonization brought about by the Directive, Member States remain the main actors in the fight against unfair practices in the sector. Moreover, the creation of enforcement authorities, imposed by the directive, even for those States that do not yet have them, could lead to the development of fruitful cooperation between them, thus filling a significant gap in the current situation, ...
Conclusions. Analysis of combined compressibility measurements and high-P crystal-structure refinements shows that high P destabilizes low-Fm muscovite. This destabilization is mainly related to bond lengths, bond angles, and di- XXXXXX, X.X. (1984): Crystal chemistry of the true micas. In Xxxxx (X.X. Xxxxxx, ed.). Rev. Mineral. 13, 13-60. XXXXX, X. & XXXXXXXX, X. & XXXXXX, X. (1989): Thermal strain analysis in the crystal structure of muscovite at 700°C. Eur. J. Mineral. 1, 625-632. XXXXXX, P. & XXXXXXX, X.X. (1995): High-pressure structural study of muscovite. Phys. Chem. Minerals 22, 170-177. mensions of both the individual coordination polyhedra & (1997): Pressure dependence of struc- and the sheets of polyhedra. Consequently, muscovite changes chemically to counteract these P-induced in- stabilities. However, even though undergoing P-induced structural changes (Xxxxxx & Xxxxxxx 1997), coexist- ing paragonite shows no clearly discernible composi- tional adjustments at pressures up to ~25 kbar. Possibly this constancy is related to the octahedrally coordinated Na in the interlayer sites and the associated intrinsically large amounts of α rotation (e.g., 16.0° at 0.001 kbar and 17.9° at 25 kbar). Such high values of would hinder enlargement of the VI sheet, as would occur by signifi- cant incorporation of Fm. Xxxxxxxx et al. (1994a, b) pre- sented similar arguments, suggesting that incorporation tural parameters of paragonite. Phys. Chem. Minerals 24, 274-280. XXXXXXX, X.X. & XXXXXXXX, X.X. (1996): The stability and composition of phengitic muscovite and associated phases from 5.5 – 11 GPa: implications for deeply subducted sediments. Geochim. Cosmochim. Acta 60, 4133-4150. XXXXX, X.X. (1963): Significance of phengitic micas from low grade schists. Am. Mineral. 48, 1357- 1373. XXXXXXXX, X.X., XXXXXXX, C., XXXXX, X.X. & XXXXXXX, X.X. (1992): Compositional controls on the cell dimensions of 2M1 muscovite and paragonite. Eur. J. Mineral. 4, 283-297. of more than minor Fm into paragonite would destabi- & XXXXX, X.X. (1976): Muscovite as petrogenetic lize it. Finally, as seen on Figure 1, paragonite is inherently less compressible than muscovite. Hence, possibly the structural changes occurring as P increases indicator mineral in pelitic schists. Neues Jahrb. Mineral., Abh. 127, 97-142. impart less instability to a paragonite crystal than a co- & (1998): Petrogenetic significance of existing muscovite crystal, thereby not requiring the compositional adjustment seen in mus...