SVCCS 1: GALANT Sample Clauses

SVCCS 1: GALANT. Glass surface coating to reduce leaching using nanoTiO2 The aim of GALANT is to analyse possible leaching of titanium dioxide (TiO2)-nanoparticles out of nano-coatings on the inner surface of glass containers that are used for storage of pharmaceutical solutions. The partners that have been involved in the study are: - AIT (XXXxXXX partner; case study leader, overall evaluation of study feasibility, work coordination, analysis of outcomes), - Stölzle-Oberglas GmbH, Austria (industrial partner; provider of specific problem, industrial know- how, materials), - Graz University of Technology (TUG), Austria (scientific partner; provider of technical know-how, performer of coating processes, certain analytical work), - Research Center Pharmaceutical Engineering GmbH (RCPE) (scientific partner; provider of technical know-how), - BioNanoNet (NANoREG partner and Austrian NC; provider of industrial contacts, support in coordination of work, dissemination of information), - SINTEF (NANoREG partner; provider of scientific and technical know-how, analytical work, compilation of technical data). The most probable exposure to TiO2 nanoparticles of relevance for this case study, besides the earlier (production) stages, is in glass containers of pharmaceutical solutions when TiO2 particles xxxxx out of the TiO2-nanocoatings into solutions that are used for pharmaceuticals, e.g. for parenteral use. Another exposure of the TiO2-nanoparticles can be in the course of the disposal of the coated glass containers. Glass containers are widely used in the pharmaceutical industry. However, a major concern regarding their use is their hydrolytic stability (this means their “corrosion resistance” in aqueous environments), particularly when using soda-lime-glass (also called “Type 3” glass). When these containers are filled with aqueous pharmaceutical solutions, alkali metals and alkaline earth metals can xxxxx out of the glass surface and alter the pH-value of the solution in the glass container. This may cause undesired interactions, such as degradation of the active pharmaceutical ingredient (API) or precipitation of biopharmaceuticals, both leading to inefficacy of the drug. Furthermore, ionic diffusion processes have a strong influence on other properties of glasses, such as electrical conductivity, viscosity, thermal expansion and chemical durability. In order to reduce the diffusion of alkali and alkaline earth metals from glass surfaces into aqueous solutions, a process that in...
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