DISTRIBUTION. (i) If syndicated, names and addresses of Managers and underwriting commitments: Not applicable.
(ii) Date of Subscription Agreement: Not applicable.
(iii) Stabilisation Manager: Not applicable.
(iv) If non-syndicated, name and address of relevant Manager, if applicable: Not applicable.
(v) Total commission and concession: Not applicable
DISTRIBUTION. Method of distribution: Non-syndicated - Dealer(s): Société Générale Tour Société Générale 17 Cours Valmy
DISTRIBUTION. Cabozantinib is highly protein bound in vitro in human plasma (≥ 99.7%). Based on the population- pharmacokinetic (PK) model, the volume of distribution (Vz) is approximately 212 L (SE: ± 2.7%). Protein binding was not altered in subjects with mild or moderately impaired renal or hepatic function (1).
DISTRIBUTION. After a single, deep subcutaneous administration, the mean absolute bioavailability of lanreotide in healthy subjects was 73.4, 69.0, and 78.4% for the 60 mg, 90 mg, and 120 mg doses, respectively. Mean Cmax values ranged from 4.3 to 8.4 ng/mL during the first day. Single-dose linearity was demonstrated with respect to AUC and Cmax, and showed high inter-subject variability. Lanreotide autogel (depot formulation) showed sustained release of lanreotide with a half-life of 23 to 30 days. Mean serum concentrations were > 1 ng/mL throughout 28 days at 90 mg and 120 mg and > 0.9 ng/mL at 60 mg. In patients with GEP-NETs treated with Lanreotide 120 mg every 4 weeks, steady state concentrations were reached after 4 to 5 injections and the mean trough serum lanreotide concentrations at steady state ranged from 5.3 to 8.6 ng/mL. Information from human studies regarding distribution of lanreotide is not available (8).
DISTRIBUTION. (i) Name(s) and address(es), to the extent known to the Issuer, of the Managers / Distributors in the various countries where the offer takes place: See paragraph 107 of Part A.
(ii) Name and address of the co-ordinator(s) of the global offer and of single parts of the offer: The Issuer will act as lead manager of the placement (Responsabile del Collocamento as defined under article 93-bis of the Legislative Decree of 24 February 1998, n. 58, as subsequently amended (the "Financial Services Act")) but will not act as manager and, accordingly, will not place any Securities to the public in Italy.
(iii) Name and address of any paying agents and depository agents in each country (in addition to the Principal Security Agent): Not applicable.
(iv) Entities agreeing to underwrite the issue on a firm commitment basis, and entities agreeing to place the issue without a firm commitment or under "best efforts" arrangements: The Issuer and the Manager have agreed under a placement agreement (the "Placement Agreement") that the Manager will place the Securities without a firm commitment.
(v) Date of signing of the placement agreement: The Placement Agreement will be dated on or about 5 July 2022.
DISTRIBUTION. (i) Method of distribution: Non-syndicated - Dealer(s): Société Générale Tour Société Générale 17 Cours Valmy
(ii) Total commission and concession:
(iii) TEFRA rules: Not Applicable
(iv) Non-exempt Offer: Not Applicable
DISTRIBUTION. Not Applicable Not Applicable Not Applicable Yes. Note that the designation "yes" simply means that the Notes are intended upon issue to be deposited with one of the ICSDs as common safekeeper, and registered in the name of a nominee of one of the ICSDs acting as common safekeeper, that is, held under the New Safekeeping Structure, and does not necessarily mean that the Notes will be recognized as eligible collateral for Eurosystem monetary policy and intra day credit operations by the Eurosystem either upon issue or at any or all times during their life. Such recognition will depend upon the ECB being satisfied that Eurosystem eligibility criteria have been met
(i) Method of distribution: Not Applicable
(ii) If syndicated, names [and addresses of the Lead Manager and the other Managers and underwriting commitments]*: Not Applicable
(iii) Date of Subscription Agreement: Not Applicable
(iv) Stabilising Manager(s) (if any): Not Applicable
(v) If non-syndicated, name and address of Dealer: Citigroup Global Markets Limited at Citgroup Centre, 33 Canada Square, Canary Wharf, Xxxxxx, X00 0XX, Xxxxxx Xxxxxxx
(vi) Total commission and concession: None
(vii) Swiss selling restrictions: Not Applicable
(viii) Non-exempt Offer: Not Applicable
(ix) General Consent: Not Applicable
(x) Other conditions to consent: Not Applicable
DISTRIBUTION. Société Générale Tour Société Générale 17, Cours Valmy 92987 Paris La Défense Cedex
DISTRIBUTION. (i) Method of distribution: Non-syndicated - Dealer(s): Société Générale Bank&Trust 00, xxxxxx Xxxxx Xxxxxx 2420 Luxembourg Luxembourg
(ii) Total commission and concession:
(iii) TEFRA rules: Not Applicable
(iv) Non-exempt Offer: A Non-exempt offer of the Notes may be made by the Dealer - Individual Consent / Name(s) and address(es) of any Initial Authorised Offeror: - General Consent/ Other conditions to consent:
(v) U.S. federal income tax considerations:
DISTRIBUTION. (i) If syndicated, names and addresses of Managers and underwriting commitments: Not Applicable Not Applicable.
(ii) Date of Distribution Agreement: The Issuer and the Distributor have entered into on 15 November 2013 an agreement (Accordo di collocamento) for the distribution of the Notes in Italy during the Offer Period (the “Distribution Agreement”).
(iii) Stabilising Manager(s) (if any): Not Applicable If non-syndicated, name and address of Dealer: Lead Manager (Responsabile del Collocamento) is Mediobanca – Banca di Credito Finanziario S.p.A – Xxxxxxxxx Xxxxxx Xxxxxx 1 – 00000 - Xxxxx, Xxxxx, xxx.xxxxxxxxxx.xxx; and Distributor (Collocatore) is CheBanca! S.p.A. – Xxxxx Xxxxx 00, Xxxxxxx 0, 00000 Xxxxx, Xxxxx, xxx.xxxxxxxx.xx . The Distributor will receive, as consideration of its distribution activity, a commission, included in the Issue Price, of up to 3.50 per cent of the Aggregate Nominal Amount of the Notes actually placed during the Offer Period.