CombiChem Responsibilities. CombiChem shall with Due Diligence conduct the following activities under the Research Program in accordance with the terms of this Agreement and as more fully described in the Research Plan:
(a) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Targets provided by ImClone; (ii) based on such data and information and using the CombiChem Technology, design informative compound libraries; and (iii) supply all lead chemistries and synthesize compounds as provided in Section 5.3 below.
(b) During the Research Period, CombiChem shall keep ImClone informed of its activities performed in connection with the Collaboration, including, without limitation, providing ImClone with data and information regarding Collaboration Compounds prior to the meetings of the Research Management Committee.
(c) Subject to Article 4 and at all times during the Research Period, CombiChem shall dedicate a project team of five (5) FTEs comprised of synthetic and analytical chemists, compound control scientists, and a computational scientist (the "Project Team") to conduct all of its activities in connection with the Collaboration; provided, however, that the RMC may at any time during the Research Period substitute employees for the FTEs described above; provided, further, that ImClone may request that CombiChem expand its Project Team by adding additional FTEs to work on the Collaboration at the rate and in the manner specified in Section 8.2(b).
CombiChem Responsibilities. CombiChem shall with Due Diligence provide the following resources to Athena and conduct the following activities under the Research Program and as more fully described in the Research Plan:
(a) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Targets provided by Athena; (ii) based on such data and information and using the CombiChem Technology, design Daughter Libraries; and (iii) supply all lead chemistries and synthesize compounds as provided in Section 5.4 below.
(b) During the Research Period, CombiChem shall keep Athena informed of its activities performed in connection with the Collaboration, including, without limitation, providing Athena with data and information (and, upon Athena's request, reasonable quantities of samples pursuant to Section 5.4) regarding the status of all Collaboration Compounds prior to the meetings of the Research Management Committee.
(c) Subject to Section 2.3, Article 3 and Section 8.3, and at all times during the Research Period, Combichem shall dedicate, in separate laboratory facilities as to its chemistry efforts, one or more project team(s) ("Project Team"), each consisting of such number of FTEs as determined by the RMC to conduct all of CombiChem's activities in connection with the collaboration at a per annum rate of U.S. *** to be paid by Athena. The initial Project Team shall consist of a minimum of five (5) CombiChem FTEs, unless the RMC determines other use.
CombiChem Responsibilities. CombiChem shall with Due Diligence provide the following resources to ICOS and conduct the following activities under the Research Program and as more fully described in the Research Plan:
(a) Within thirty (30) days of the Effective Date, CombiChem will deliver to ICOS its UIL sufficient in quantity for ICOS to screen against the Initial Target and any Target contained in Appendix B at the time of such shipment.
(b) At any time following the Effective Date, CombiChem shall provide to ICOS data analysis and evaluations for results from the screening of the UIL against the Initial Target and any substituted Alternative Target under Section 3.2(b) herein within *** of CombiChem's receipt of the relevant screening data from ICOS.
(c) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Target provided by ICOS and derived from the UIL by CombiChem; (ii) based on such data and information and using the CombiChem Technology, design Daughter Libraries; and (iii) supply all lead chemistries and synthesize compounds as provided in Section 5.4 hereof.
(d) During the Research Period, CombiChem shall keep ICOS informed of its activities performed in connection with the Collaboration, *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.
(e) Subject to Section 2.3, Article 3 and Section 8.3 hereof, and at all times during the Research Period, CombiChem shall dedicate, in separate laboratory facilities as to its chemistry efforts *** to conduct all of CombiChem's activities in connection with the Collaboration at a per annum rate of U.S. *** per FTE to be paid by ICOS. The *** unless the RMC recommends otherwise and ICOS and CombiChem agree in writing to alter the size of *** .
CombiChem Responsibilities. CombiChem shall conduct the following activities under the Research Program in accordance with the terms of this Agreement and as more fully described in the Research Plan:
(a) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Targets provided by Sumitomo ; (ii) based on those data and information and using the CombiChem Technology , design compound libraries; and (iii) synthesize compounds as provided in Section 4.4 below. *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.
(b) During the Research Period, CombiChem shall keep Sumitomo fully informed of its activities performed in connection with the Collaboration, including, without limitation, by providing Sumitomo with data and information regarding Collaboration Compounds prior to the meetings of the Research Management Committee.
(c) During the Research Period, CombiChem shall provide space and resources to accommodate the Sumitomo scientists described in Section 2.2 below.
(d) During the Research Period , CombiChem shall provide a minimum of *** .
(e) During the Research Period and while *** *** , CombiChem shall provide Sumitomo with reasonable technical support to facilitate Sumitomo's establishment of an *** *** *** *** *** *** .
CombiChem Responsibilities. CombiChem shall, with Due Diligence, provide the following resources to ONO and conduct the following activities under the Lead Generation Program, as more fully described in the Research Plan: *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission
(a) Prior to the Effective Date, (i) CombiChem has reviewed data and information regarding the Research Target provided by ONO and derived from the UIL by CombiChem and (ii) both Parties have agreed upon the Research Plan under the Screening Agreement. During the Research Period, based on the data and information described above and such additional data and information as may be provided by ONO after the Effective Date and using the CombiChem Technology, CombiChem shall design Research Libraries as a part of the LGP and supply all lead chemestries and synthesize Research Compounds as provided in Section 4.4 hereof. CombiChem shall make commercially reasonable efforts to identify Research Compounds which satisfy the First Year Benchmarks on or before the first anniversary of the commencement of the Research Period and to identify Preclinical Lead Compounds on or before the expiration of the Research Period.
(b) During the Research Period, CombiChem shall keep ONO informed of its activities performed in connection with the Lead Generation Program, including, without limitation, providing ONO with data and information (and, upon ONO's request, reasonable quantities of samples pursuant to Section 4.4 hereof) regarding the status of all Research Compounds prior to the meetings of the RMC. CombiChem shall also establish a method of synthesis as provided in Section 4.5 hereof.
(c) Subject to Section 2.3 and 8.2 hereof and Article 3 hereof, CombiChem shall provide one (1) project team ("Project Team") to conduct CombiChem's activities in connection with the Lead Generation Program at a per annum rate of *** *** to be paid by ONO pursuant to subsections 8.2 (a), (b) and (c) hereof. The initial Project Team shall consist of a minimum of *** CombiChem FTEs, unless both Parties determine otherwise pursuant to subsection 8.2(c) hereof.
(d) CombiChem shall maintain research records in reasonably sufficient detail comparable to the way they are maintained for CombiChem's own research programs and in good scientific manner appropriate for ONO's Patent purposes, which shall reflect all work done and results achieved in accordance with the LGP. Upon ON...
CombiChem Responsibilities. CombiChem shall with Due Diligence provide the following resources to Athena and conduct the following activities under the Research Program and as more fully described in the Research Plan:
(a) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Targets provided by Athena; (ii) based on such data and information and using the *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the commission.
CombiChem Responsibilities. CombiChem shall with Due Diligence conduct the following activities under the Research Program in accordance with the terms of this Agreement and as more fully described in the Research Plan:
(a) During the Research Period, CombiChem shall (i) review data and information regarding the Collaboration Targets provided by ImClone; (ii) based on such data and information and using the CombiChem Technology, design informative compound libraries; and (iii) supply all lead chemistries and synthesize compounds as provided in Section 5.3 below.
(b) During the Research Period, CombiChem shall keep ImClone informed of its activities performed in connection with the Collaboration, including, without limitation, providing ImClone with *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the commission.
CombiChem Responsibilities. (a) During the Research Program Term, CombiChem shall synthesize *** Libraries. Such Libraries shall be provided to Teijin according to the schedule set forth in the Research Plan. The Libraries shall be provided in 96-well plates or Eppendorf tubes, and shall contain the quantities of Library Compounds set forth on Exhibit B; *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.
(b) During the Research Program Term, CombiChem shall keep the RC fully informed of its activities performed in connection with the Collaboration, including, without limitation, by providing the RC with data and information regarding Libraries, Collaboration Compounds and structures thereof;
(c) During the Research Program Term, CombiChem shall provide an average of *** *** to conduct CombiChem's activities under the Research Program; and
(d) During the Research Program Term, CombiChem shall provide space and resources to accommodate the FTE Teijin chemist (described in Section 2.1.2(c) below).
CombiChem Responsibilities. CombiChem shall with Due Diligence provide the following resources to ICOS and conduct the following activities under the Research Program and as more fully described in the Research Plan:
(a) Within *** of the Effective Date, CombiChem will deliver to ICOS its UIL sufficient in quantity for ICOS to screen against the Initial Target and any Target contained in Appendix B at the time of such shipment. The Parties hereby agree that the obligations and responsibilities in this Section 2.1(a) have been fully and finally completed and performed by the Parties as part of a separate agreement between the Parties and constitute separate and valuable consideration between the Parties in respect of this Agreement.
(b) At any time following the Effective Date, CombiChem shall provide to ICOS data analysis and evaluations for results from the screening of the UIL against the Initial Target within *** of CombiChem's receipt of the *** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.
CombiChem Responsibilities. (a) During the Research Program Term, CombiChem shall *** . Such Libraries shall be provided to Teijin according to the schedule set forth in the Research Plan. The Libraries shall be provided in 96-well plates or Eppendorf tubes, and shall contain the quantities of Library Compounds set forth on Exhibit B;
(b) During the Research Program Term, CombiChem shall keep the RC fully informed of its activities performed in connection with the Collaboration, including, without limitation, by providing the RC with data and information regarding Libraries, Collaboration Compounds and structures thereof;
(c) During the Research Program Term, CombiChem shall provide an *** *** under the Research Program; and
(d) During the Research Program Term, CombiChem shall provide space and resources to accommodate *** *** .
