Principle and scope Sample Clauses

The "Principle and scope" clause defines the fundamental purpose and boundaries of the agreement or policy it introduces. It typically outlines the main objectives, the parties involved, and the specific subject matter or activities covered. For example, it may clarify whether the agreement applies to all employees, only certain departments, or specific types of transactions. By establishing what is and is not included, this clause ensures all parties have a clear understanding of the agreement’s intent and limits, thereby preventing misunderstandings and disputes about its application.
Principle and scope. The original SOP “Final protocol for producing suitable manufactured nanomaterial exposure media” was developed as a generic approach for the preparation of batch dispersions for in vitro and in vivo toxicity testing in the NANOGENOTOX project [21]. The method aims to produce a highly dispersed state of any MN by ethanol (EtOH) pre-wetting to handle hydrophobic materials followed by dispersion in sterile-filtered 0.05% w/v BSA-water at a fixed concentration of 2.56 mg/ml using probe sonication. The protocol may not produce the smallest possible particle size in the dispersion, but is a generically applicable procedure that ensures reasonable dispersion of the test materials selected for the NANOGENOTOX project, with the aim to use or characterize the dispersion immediately after its production [21]. To precisely and accurately measure the size and shape of (nano)materials in the context of the EC definition [22] using TEM, it is efficient to modify the generic dispersion protocol. For the examined materials and conditions, a minor modification omitting the pre-wetting step with EtOH and the treatment with 0.05% w/v BSA-kept the particles in a highly dispersed state, allowed representative transfer to an EM-grid, and it improved the separation of the particles from the background based on mass-density contrast and the identification of the primary particles in aggregates.
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Principle and scope. The proposed method for preparation of EM specimens brings particles in dispersion in contact with an EM-grid and allows them to interact with the grid surface. When excess fluid is drained of and grids are air-dried, a fraction of the particles remains attached to the grid by different types of interactions (electrostatic, apolar, van der Waals). This procedure aims to prepare a TEM specimen from dispersed particles. The concentrations of particles, and the type and charge of the grid are chosen such that the fraction of nanoparticles attached to the grids optimally represents the dispersed particles, and that the particles of interest can be detected individually. Transfer of the particles to the grid is not complete such that absolute counts cannot be realized. The SOP is useful for particles that can be metallic, metal oxides or other. The particles can be monodisperse or polydisperse, aggregated or not. The medium can be polar (water, phosphate buffered saline,...) or apolar (hexane, acetone,…). The prepared EM specimens are useful for descriptive TEM analyses or quantitative TEM analyses. To be suitable for quantitative TEM analysis, the particles should be evenly distributed over the grids, while the fraction of the attached NPs represents the dispersed particles optimally.
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Principle and scope. A descriptive or qualitative EM analysis aims to provide a description of specific physical properties of a nanomaterial that determine, among others, its interaction with biological and environmental systems based on calibrated, bright-field TEM or SEM micrographs taken at low to intermediate magnification. It allows evaluating under which physical form the NM is exposed to in vivo and in vitro test systems, and whether a subsequent quantitative TEM analysis of the NM is feasible. The procedure is based on guidelines described in literature [70, 78-82]. In principle this method allows to describe the characteristics of any kind of nanoparticles. A descriptive EM analysis includes (i) an estimate of the size (distribution) of the primary and aggregated/agglomerated particles: (ii) representative and calibrated micrographs; (iii) the agglomeration- and aggregation status; (iv) the general morphology; (v) the surface topology; (vi) the structure (crystalline, amorphous, …); (vii) and the presence of contaminants and aberrant particles. In addition, such qualitative analysis evaluates the relevance and suitability of a quantitative TEM analysis based on the amount of particles on the EM grid and the homogeneity of their distribution. The proposed methodology complies with the EFSA Guidance document that foresees application of electron microscopy (TEM) such that the generated data is in line with the current Guidance document. It describes several key parameters important to assess the nanoparticle safety as specified in [28, 29, 63, 64].
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Principle and scope. The proposed method for TEM imaging of nanomaterials aims to record a set of calibrated transmission electron micrographs showing particles that are representative for the NM on the EM grid starting from EM specimens containing particles that optimally represent the particles in the original sample, and that contain particles of interest that can be detected individually. The TEM specimen preparation can be performed based on the grid-on-drop or drop-on-grid methods described in 3.2 , or on other specimen preparation methods including cryo-EM, aerosol sampling and on grid ultracentrifugation centrifugation. To assure unbiased random image collection the systematic micrograph selection procedure of ▇▇ ▇▇▇▇▇▇▇▇▇ et al. [11] is applied. The magnification of the micrographs and the number of particles (micrographs) are determined such that the images are suitable for subsequent descriptive and quantitative image analyses. The pixel size and the associated magnification is determined based on the criterion of Merkus [53]. The upper size detection limit is limited to one tenth of the image size supporting on ISO 13322-1, 2014 [54]. The number of particles required to estimate a quantitative parameter with a certain confidence level is determined based on the method proposed by ▇▇ ▇▇▇▇▇▇▇▇▇ et al. [9, 51].
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Principle and scope. This procedure aims to analyse the 2D properties of the particles on EM micrographs. To be suitable for quantitative characterisation, the images should have a homogeneous background and the particles should be clearly distinguishable from the background. This method allows characterising NM on EM-micrographs using image analysis software.  The NM can be metallic consisting for example of Ag or Au, an oxide including SiO2, TiO2,Fe2O3, Fe3O4 ,and other.  The NM can be monodisperse or polydisperse.  Freeware and/or commercial image analysis softwares can be applied.
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Principle and scope. This procedure aims to analyse the 2D properties of the primary particles on EM micrographs. The image analysis program detects aggregated particles on an EM micrograph based on their grey value, which reflects the mass-density contrast of the material. Aggregates that are distinguishable from the background are detected and semi-automatically measured. Multiple measurands are measured simultaneously on individual aggregates. The primary particles in the aggregates are detected based on watershed segmentation and their minimal size and overlap coefficient are measured based on an Euclidean distance map. A typical particle analysis consists of following steps: • Image preparation • Setting and adjusting the threshold value • Defining the detection area • Setting the detection parameters • Detection of the primary particles in aggregated NM • Selection of the primary particle parameters • Defining the classification schemes • Classification of the particles according the selected parameters • Exporting of results in excel spreadsheets and storage of the (annotated) images in the NM database
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Principle and scope. 1. Member States shall include in their CAP Strategic Plans a system of conditionality, under which farmers and other beneficiaries receiving direct payments under Chapter II of this Title or the annual payments under Articles 65, 66 and 67 shall be subject to an administrative penalty if they do not comply with the statutory management requirements under Union law and the GAEC standards established in the CAP Strategic Plan, as listed in Annex III, relating to the following specific areas: (a) the climate and the environment, including water, soil and biodiversity of ecosystems; (b) public health, animal health and plant health; (c) animal welfare. 2. The rules on an effective and proportionate system of administrative penalties to be included in the CAP Strategic Plan shall respect in particular the requirements set out in Chapter IV of Title IV of Regulation (EU) [HzR]. 3. The legal acts referred to in Annex III concerning the statutory management requirements shall apply in the version that is applicable and, in the case of Directives, as implemented by the Member States. 4. For the purpose of this Section, 'statutory management requirement' means each individual statutory management requirement under Union law listed in Annex III within a given legal act, differing in substance from any other requirements in the same act.
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Principle and scope. At the latest by 1/1/2025, Member States shall include in their CAP Strategic Plans that farmers and other beneficiaries receiving direct payments under Chapter II of this Title or the annual payments under Articles 65, 66 and 67 of this Regulation shall be subject to an administrative penalty if they do not comply with the requirements related to applicable working and employment conditions or employer obligations arising from the legal acts referred to in Annex XX.
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Related to Principle and scope

  • Definitions and Scope 1.1 Employees shall have the right to present grievances in accordance with the procedures prescribed in this Article. 1.2 For purposes of this Agreement, a grievance is a dispute concerning the interpretation or application of the terms or provisions of this Agreement. It is intended that this shall not mean administrative matters under the Retirement System and the Group Health Insurance Program.

  • Objectives and Scope 1. The Parties confirm their joint objective of strengthening and deepening their relations in all fields covered by this Agreement by developing their political dialogue and reinforcing their co-operation. 2. The Parties confirm their joint objective of working towards creating conditions under which, building on the outcome of the Doha Work Programme, a feasible and mutually beneficial Association Agreement, including a Free Trade Agreement, could be negotiated between them. 3. Implementation of this Agreement should help to create these conditions by striving for political and social stability, deepening the regional integration process and reducing poverty within a sustainable development framework in the Andean Community. 4. This Agreement governs the political dialogue and co-operation between the Parties and contains the necessary institutional arrangements for its application. 5. The Parties undertake to periodically assess progress, taking account of progress achieved before the entry into force of the Agreement.

  • Purpose and Scope The purpose of these standard contractual clauses is to ensure compliance with the requirements of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data (General Data Protection Regulation)1 for the transfer of personal data to a third country.

  • Object and Scope of the Agreement The competent authorities of the Contracting Parties shall provide assistance through exchange of information that is foreseeably relevant to the administration and enforcement of the domestic laws of the Contracting Parties concerning taxes covered by this Agreement. Such information shall include information that is foreseeably relevant to the determination, assessment and collection of such taxes, the recovery and enforcement of tax claims, or the investigation or prosecution of tax matters. Information shall be exchanged in accordance with the provisions of this Agreement and shall be treated as confidential in the manner provided in Article 8. The rights and safeguards secured to persons by the laws or administrative practice of the requested Party remain applicable to the extent that they do not unduly prevent or delay effective exchange of information.

  • Definitions and Schedules 1.1 Words and phrases contained in this Agreement (whether capitalized or not) that are not defined in this Agreement have the meanings given to them in the Electricity Act, 1998, the Ontario Energy Board Act, 1998, any regulations made under either of those Acts, or the Code. 1.2 The following schedules form part of this Agreement: Schedule A – Application and Connection Cost Agreement (recitals) Schedule B – Single Line Diagram, Connection Point and Location of Facilities (section 2.3) Schedule C – List of Other Contracts (section 3.4) Schedule D – Technical and Operating Requirements (section 4.1(d)) Schedule E – Billing and Settlement Procedures (section 5.3) Schedule F – Contacts for Notice (section 12.1) Schedule G – Dispute Resolution (section 16.1) 1) Where a schedule is to be completed by the Parties, the Parties may not include in that schedule a provision that would be contrary to or inconsistent with the Code or the remainder of this Agreement.