Aim 2. The brain and spinal cord of EAE and control mice will be harvested for two sets of experiments.
Aim 2. My group will continue further development of the lead compounds (NB74, NB84 and NB124) to establish the formulation for increased bioavailability and acute delivery (instead of systemic delivery, e.g. intravenous and/or subcutaneous injection as they have been tested until to date). Shortly, because aminoglycosides (AGs), like gentamicin and our leads XX00, XX00 and NB84 are highly charged, water soluble compounds, they poorly absorb through intestinal tissues and therefore are usually administered by injection. In addition, AGs are short-lived molecules in the circulatory system, being rapidly eliminated by glomerular filtration in the kidney. They also exhibit poor permeability into eukaryotic cells, which requires their administration in higher dosages that in turn causes harmful side effects and limits their use in translational therapy. To solve these problems, we have initiated two different but complementary directions.
Aim 2 i. We will strive to eliminate long-standing barriers to institution-wide cross-cutting research initiatives and provide the wherewithal for scientists and clinicians to collaborate.
Aim 2 a. Established 2 successful contracts for specimen collections with the NIH Cancer Genome Atlas Program through the Cancer Center Tissue Bank Core Facility.
Aim 2 i. In collaboration with the CTSI Research Navigator and Alianza, Research Ethics, and Research Training Components, initiated cooperation with Office of Regulatory Support and Quality Assurance to inventory and consolidate regulatory tools, templates, and training resources.
ii. In collaboration with Miami Center for Research Participation & Partnership, Research Ethics, and Research Training Components, hosted a day-long planning meeting represented by four CTSAs to identify curriculum content for Clinical Research Coordinator training program to be developed for presentation via CITI IT platform.
iii. To publicize Component services, presented poster of Regulatory Knowledge & Support Component goals, programs, and resources at CANESEARCH.
Aim 2. To expose a broad spectrum of students, trainees, faculty, research staff, and community collaborators to the principles of translational science and the standards of good practice in clinical research
i. Developed ethics training for research staff, graduate students, postdoctoral research fellows, early career investigators, etc. Coordinated with ¡Alianza! and University of Miami Office of Regulatory Support and Quality Assurance to develop training and certification of Clinical Research Coordinators and staff, including Bootcamp; 17 short courses which are in the process of being placed online utilizing the CITI online platform, to address issues such as informed consent, protocol compliance, and other key clinical research areas; and an internship/mentoring component.
Aim 2. Conduct a rigorous and on-going evaluation of the CTSI and its components to:
Aim 2. Conduct a rigorous and on-going evaluation of the CTSI and its components
a. Develop and conduct evaluation surveys with users of the CTSI component services
b. Collect data on the identified metrics for the overall CTSI and the components using developed tracking methodologies
c. Summarize collected data and rigorously evaluate progress of each component and overall CTSI relative to specific aims and to plans outlined in 2013 Annual Report (current report)
Aim 2. 1.1 The aim of the service is to offer free starter packs for oral contraception (POP - Progestogen-only Pill) under a PGD as a bridging method (3-month supply, 1x84 pack with a view to direct referral to a GP or community sexual health for ongoing support and review of method). This service is provided with a view to service users obtaining further supplies via their local GP (first and foremost) or from a local sexual health clinic.
Aim 2. Describe the association between personal PM2.5 exposure from household air We modeled the cross-sectional data via a multivariate linear regression model. Many studies have modeled the impact of PM2.5 on BP using regression analysis [22, 23]. Some additional predictors of interest include: age, Body Mass Index (BMI), and time of day of BP data were obtained. Per CHAP study restriction, any woman who was pregnant or planning to become pregnant, smoked daily, or has hypertension were excluded from the study. Our models were run for SBP and DBP.
