Aim 2. Conduct a rigorous and on-going evaluation of the CTSI and its components to:
Aim 2. 1.1 The aim of the service is to offer free starter packs for oral contraception (POP - Progestogen-only Pill) under a PGD as a bridging method (3-month supply, 1x84 pack with a view to direct referral to a GP or community sexual health for ongoing support and review of method). This service is provided with a view to service users obtaining further supplies via their local GP (first and foremost) or from a local sexual health clinic. 2.1.2 In the case of the above, the contraception provided should be offered as a follow on to the Emergency Hormonal Contraception initial consultation. This specification does not yet define for use off the EHC pathway, ie. for routine visits, starts and/or repeats where women are already on effective methods (this work is in development – future plans).
Aim 2 i. We will strive to eliminate long-standing barriers to institution-wide cross-cutting research initiatives and provide the wherewithal for scientists and clinicians to collaborate.
Aim 2 a. Established 2 successful contracts for specimen collections with the NIH Cancer Genome Atlas Program through the Cancer Center Tissue Bank Core Facility.
Aim 2 i. In collaboration with the CTSI Research Navigator and Alianza, Research Ethics, and Research Training Components, initiated cooperation with Office of Regulatory Support and Quality Assurance to inventory and consolidate regulatory tools, templates, and training resources.
Aim 2. To expose a broad spectrum of students, trainees, faculty, research staff, and community collaborators to the principles of translational science and the standards of good practice in clinical research
Aim 2. Describe the association between personal PM2.5 exposure from household air pollution and blood pressure in adult non-hypertensive, non-smoking, non-pregnant women age 25 to 65 who use biomass cookstoves in Puno, Peru. We modeled the cross-sectional data via a multivariate linear regression model. Many studies have modeled the impact of PM2.5 on BP using regression analysis [22, 23]. Some additional predictors of interest include: age, Body Mass Index (BMI), and time of day of BP data were obtained. Per CHAP study restriction, any woman who was pregnant or planning to become pregnant, smoked daily, or has hypertension were excluded from the study. Our models were run for SBP and DBP.
Aim 2. The brain and spinal cord of EAE and control mice will be harvested for two sets of experiments.
Aim 2. My group will continue further development of the lead compounds (NB74, NB84 and NB124) to establish the formulation for increased bioavailability and acute delivery (instead of systemic delivery, e.g. intravenous and/or subcutaneous injection as they have been tested until to date). Shortly, because aminoglycosides (AGs), like gentamicin and our leads XX00, XX00 and NB84 are highly charged, water soluble compounds, they poorly absorb through intestinal tissues and therefore are usually administered by injection. In addition, AGs are short-lived molecules in the circulatory system, being rapidly eliminated by glomerular filtration in the kidney. They also exhibit poor permeability into eukaryotic cells, which requires their administration in higher dosages that in turn causes harmful side effects and limits their use in translational therapy. To solve these problems, we have initiated two different but complementary directions.
Aim 2. Identify the Historical Basis for the Policies A thorough literature review and search of xxxx literature, as shown in Figure 1, allowed for the compilation of a timeline delineating the major events, conferences, and decision points that shaped the growth of the “country ownership” concept. The timeline begins in 1996, and continues until 2020 (the year this analysis was completed). Focus was given to developments as they related to the donor-recipient relationship between country governments, the private sector, and multilateral organizations. Documents which pertained solely to the finance of unilateral organizations were excluded, as the scope of this paper encompassed global public private partnerships such as Gavi and the Global Fund. Organizations like the Presidential Emergency Plan for Aids Relief, while also responsive to the movement toward country ownership of public health programs, were excluded for this reason. Documents from the UN speaking specifically to the donor-recipient relationship, country ownership, and the changing expectations in the use of development assistance for health were included.
