Experimental. Shall be defined as all procedures and treatments not covered under the Medicare Program (Title XVlll of Social Security Act of 1965, as amended), unless otherwise specifically included or excluded under this Agreement.
Experimental. INVESTIGATIVE - the use of any treatment, Service, procedure, facility, equipment, drug, device or supply (intervention) which is not determined by the Plan to be medically effective for the condition being treated. The Plan will consider an intervention to be Experimental/Investigative if:
a. the intervention does not have FDA approval to be marketed for the specific relevant indication(s); or
b. available scientific evidence does not permit conclusions concerning the effect of the intervention on health outcomes; or
c. the intervention is not proven to be as safe and as effective in achieving an outcome equal to or exceeding the outcome of alternative therapies; or
d. the intervention does not improve health outcomes; or
e. the intervention is not proven to be applicable outside the research setting. If an intervention as defined above is determined to be Experimental/Investigative at the time of Service, it will not receive retroactive coverage even if it is found to be in accordance with the above criteria at a later date.
Experimental. Materials and reagents Physical measurements
Experimental. PLAN The experimental details that follow are approximate and may be changed upon mutual agreement of the NCI and Kite. Any change in the scope of this CRADA will be by mutual consent and written Amendment to the CRADA. […***…]. […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 28 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 29 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 30 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 31 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 32 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 33 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 34 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. DESCRIPTION OF THE CONTRIBUTIONS AND RESPONSIBILITIES OF THE PARTIES — […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 35 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH — […***…]. — […***…]. — […***…]. PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 36 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH — […***…]. RELATED NCI AND COLLABORATOR AGREEMENTS: NONE RELATED INTELLECTUAL PROPERTY AND BUSINESS/SCIENTIFIC EXPERTISE OF THE PARTIES
Experimental. The Seebeck coefficient was measured using a home-made sample holder built on a PPMS puck. It consists of two copper blocks separated by a thermal insulator plastic. The copper has a high thermal conductance so the blocks are at a uniform temperature while a temperature gradient is produced be- tween them. A small heater (maximum power of 5 W) is installed in the upper block. Its temperature is measured with a Pt-100 resistor and controlled with an external temperature controller. The temperature of the lower block is controlled by the set point of the PPMS, but the temperature was separately measured by a second Pt-100 resistor. The whole setup is covered with a stainless steal cup that isolates the sample holder to help stabilize the tem- perature gradient. The measurements were done in a relatively low vacuum of 10 mTorr. A schematic of the sample holder is given in Fig.6.1 The samples consisted of thin films, mostly on sapphire substrates, with an area of 10 × 10 mm2. CrO2 films were deposited by Chemical Vapor Deposition (CVD) on both isostructural TiO2(100) and sapphire (1000) sub- strates. CrO2 films deposit epitaxially on TiO2 in the form of rectangular grains aligned along c-axis but on sapphire the grains are aligned with six fold rotational symmetry coming from the hexagonal structure of the substrate, as detailed in Chapter 3. The Py thin films were deposited using dc sputter- ing in a UHV sputtering system, with a base pressure of 10−9 mbar, the Co films were deposited in Z-400 an RF sputtering system with base pressure of 10−6 mbar. Both Py and Co were deposited on sapphire substrates because of its better thermal conductivity. The Seebeck coefficient was recorded with reference to copper since Cu wires were connected at both ends of the film via pressed Indium. The po- tential difference was probed using a Nanovoltmeter (Xxxxxxxx 2018) in an open circuit geometry (J = 0). A dynamic technique was utilized to measure TEM as function of temperature in which the temperature difference between hot and cold point was always 5 K, while the temperature of the cold point was increased by 10 K in each step. In this way hot point and cold point interchanged in each step between the temperature range of 100 - 400 K [80]. To check the setup, TEP was measured for nonmagnetic Cu, Au, and Pt with reference to Cu. In principal, it should give a zero TEP on a Cu thin film, but we measured around 2.5 µV at temperature difference of 45 K with the hot terminal b...
Experimental. Single crystals of Ba(Fe1-‐xCox)2As2 were grown by a self-‐flux method as described elsewhere.7 The superconducting Tc is 22.5 K, and wavelength dispersive spectroscopy shows that x = 0.074, making this an optimally doped sample. In Ref. 4 Xxx and collaborators used a TDR to obtain global measurements of the temperature-‐induced change of the in-‐plane London penetration depth. The technique is described in Ref. 4 and references therein. In this work, we report local penetration depth measurements performed on the same sample. The sample was primarily stored in a desiccator, but was exposed to atmosphere during shipment and cooldown. No additional cleaving was performed and the sample was measured as received after TDR measurements, which occurred 30 months prior. We use a scanning superconducting quantum interference device susceptometer (SSS) to measure the local diamagnetic response of the sample at three locations, as described previously.8 The temperature-‐induced changes in diamagnetic response can be converted to changes in penetration depth by the scanner calibration constant, which dominates our 7% systematic uncertainty in Δλab(T).8 By repeating the SSS measurement at different locations on the same sample, we can observe any large scale inhomogeneity (>100 µm) in the sample, if it is present. To account for a slow, irreproducible drift in the measurement, we report data that re-‐traces itself on sweeping the temperature up and down.
Experimental. The metallocenes,6 open metallocenes,7 and Fe(C5H5)(2,4-C7H11)8 were prepared by published procedures. The aerogels were kindly prepared and supplied by Dr. Xxxxx Xxxx in the Eyring group. Prior to the incorporation of metal complexes, the aerogels were heated to 150º and maintained under vacuum at that temperature for 2 hours. They were then stored in a glovebox until needed. F-T reactions were carried out by the Eyring group. Deposition into monolithic aerogels was carried out under static vacuum. The appropriate organometallic compound and the aerogel were prevented from physical contact using wire screen. For deposition into powdered samples for spectroscopic studies, a finely powdered aerogel was placed together with the appropriate compound into a Schlenk tube, which was then evacuated and rotated continuously for several hours to ensure uniform incorporation. Solid state NMR spectroscopic studies were carried out by Dr. Xxxxx Xx and Xxxx. Xxx Xxxxxxx. XAFS/XXXXX, TEM, and Xxxxxxxxx studies have been carried out by Xxxx. Xxxxx X. Huggins, Prof. Xxxxxx Xxxx, and Xxxx. Xxxxxx X. Huffman, while ESR and magnetic measurements were carried out by Xx. Xxxxxxxx Xxxxx and Xxxx. Xxxxxxxx Xxxxxx. Samples for F-T reaction studies under supercritical conditions have been sent to Prof. Xxxxx Xxxxxxx.
Experimental. A variable volume view cell (VVVC) unit (Fig. 1) was used to measure the critical properties of hexane and SCH-FTS mixture. The VVVC unit consists of high-pressure variable volume view cell, manual pressure generator, temperature controller, heating tape, pressure gauge, syringe pump, stirring bar, and stirring plate. The volume of the cell can be adjusted by displacement of an internal movable piston controlled by a manual pressure generator (High Pressure Equipment Model 87-6-5) filled with isopropanol and used to manipulate the pressure in the view cell. The dynamic seal between the piston and the walls of the vessel is achieved by using four Viton O-rings. A video camera (QuickCam Pro 4000) system with a fluorescent ring light was mounted close to the ½`` thick quartz window on the front of the cell. Images of the phase transition from vapor-liquid equilibrium (VLE) to supercritical phase and vice versa were digitally recorded on the PC. The temperature in the cell was measured and controlled with a type PR-11 1/16'' RTD (Omega Engineering) and a self tuning PID controller (Omega CN76030) wired to a magnetic contactor (Omega MC-2-2-40-120), respectively. The cell was heated by using a heavy insulated tape 1/2''×2' (Omega; FGH051) and the accuracy of the measured temperatures was ±0.2 °C. The pressure was measured with a Dynisco flush mount transducer (model TPT-432A) with an accuracy of ±0.5 bar.
Experimental. An apparatus was designed for carrying out methanol reforming under supercritical water conditions. Various parts and equipment were acquired and assembled. The flow diagram for the process is shown below in Figure 1. A mixture of methanol and water is fed to the reactor by means of HPLC pump (Waters 590) after passing through a rupture disc. The pump displays the flow rate and pressure on its panel. The reactor consists of a coil of Inconel 600. (Length of the reactor = 1 m, ID = 0.0426”) The reactor is heated with the help of a tubular furnace with temperature controller (Barnstead Thermolyne, Model 21100). The ends of the tube furnace are insulated properly in order to minimize the heat loss and for the proper control of the temperature. A K-type thermocouple (Omega) measures the reactor temperature just before the exit of the reactor. The reactor is then cooled to 20 °C using a double coiled heat exchanger with cooling water as coolant. Pressure is read using the pressure gauge P. The pressure is then let down using a back-pressure regulator (Straval) which is set at 4000 psi. The vapor and liquid mixture is then separated in the phase separator packed with glass beads. The liquid flow rate measured and its TOC content is measured using a TOC analyzer (Xxxxxx-Xxxxxxxx). The gas phase exiting the phase separator passes through a volumetric flow meter (Omega FMA-1600) which displays flow rate, pressure, temperature and the computer attached to it provides the value for totalized flow. The gas mixture is then sent to a six-port injection valve (Valco) for online injection to the GC. The sample loop has a volume of 100 μL. Helium (BOC gases, 5.0 grade) is used as carrier gas. The gas mixture is fed to a gas chromatograph (Varian 3700) with a TCD detector. The GC contains a carbon molecular sieves packed column. (60/80 Carboxen-1000, Supelco, 15’ x 1/8”) The Peaksimple chromatography data system (SRI, Model 203) converts the analog signal from GC and feeds it to the computer for peak area analysis. The TCD of the GC was calibrated using a gas mixture of known composition. (BOC gases, H2 60%, CO 15%, CO2 20%, CH4 5%). A carbon monoxide detector (Nighthawk) with alarm is installed for safety purpose. T Rupture disc T Cooling water P Heat exchanger HPLC pump Gas flow meter Phase separator Peak analysis on PC Data aquisition system Liquid phase TOC analyzer/ HPLC GC with TCD CO detector with alarm Feed tank (Aqueous MeOH)
Experimental. Theoretically, the aqueous-phase reforming of one mole of ethylene glycol would produce five moles of hydrogen. C2H6O2 + 4H2O = 5H2 + 2CO2 Alumina-supported platinum catalysts were prepared by incipient wetness impregnation with aqueous solutions of tetraammineplatinum nitrate (Pt (NH4)4(NO3)2), followed by treatment in an oven at 100oC for 12 h. Then the catalysts with a composition of Pt (1 wt %) and Al2O3 (99 wt %), were calcinated at 260oC for 2 h. The calcined catalysts were then sieved to a 120–230-mesh size (particle diameters between 63 and 125 µm) and loaded into a microautoclave. The aqueous-phase reforming of ethylene glycol was carried out in a horizontal shaking microautoclave system. The microreactor had three parts: a horizontal reactor tube (1 in. o.d. x 4.625 in.), a vertical reactor stem (1/2 in. o.d. x 10 in.) and a multiport valve connected on top of the system. After 0.5 g catalyst was loaded, the reactor was purged with H2 and pressurized to 300 psi at room temperature to test for leakage. The reactor was then purged four times with H2 to remove the air. The reactor was immersed into a fluidized sand bath and heated to the final reduction temperature of 250oC. It was then purged with H2 and pressurized to 400psi at 250oC for 30 minutes to reduce the catalyst. After reduction, the system was cooled to room temperature. The system was purged with He four times to remove the H2. A 15ml liquid solution of 10 wt% ethylene glycol in deionized water was introduced into the reactor with a pump. The reactor was then immersed into the fluidized sand bath and heated to the final reaction temperature of 220oC, during with it was shaken horizontally at 200 cycles per minute. After 6 hours the reaction was terminated. The reactor was rapidly removed from the sand bath and cooled with running cold water. Before opening the reactor to collect the liquid product, the gas product was collected by a gas collector and analyzed by GC (HP6890). The liquid product was analyzed by another GC (HP5890).
