Chronic Toxicity Sample Clauses

The Chronic Toxicity clause defines the standards and procedures for assessing the long-term harmful effects of a substance or product when exposed to humans, animals, or the environment over an extended period. Typically, this clause outlines the required testing protocols, reporting obligations, and acceptable thresholds for chronic toxicity, often referencing regulatory guidelines or scientific studies. Its core function is to ensure that products or substances do not pose unacceptable long-term health or environmental risks, thereby protecting users and complying with safety regulations.
Chronic Toxicity. The discharge is subject to determination of “Pass” or “Fail” from a chronic toxicity test using the Test of Significant Toxicity (TST) statistical t-test approach described in National Pollutant Discharge Elimination System Test of Significant Toxicity Implementation Document (EPA 833-R-10-003, 2010), Appendix A, Figure A-1 and Table A-1, and Appendix B, Table B-1. The null hypothesis (Ho) for the TST statistical approach is: Mean discharge “in-stream” waste concentration (IWC) response ≤0.75 × Mean control response. A test result that rejects this null hypothesis is reported as “Pass”. A test result that does not reject this null hypothesis is reported as “Fail”. This is a t-test (formally Student’s t- test), a statistical analysis comparing two sets of replicate observations—in the case of WET test, only two test concentrations (i.e., a control and IWC). The purpose of this statistical test is to determine if the means of the two sets of observations are different (i.e., if the IWC or receiving water concentration differs from the control (the test result is “Pass” or “Fail”)). The ▇▇▇▇▇’▇ t-test employed by the TST statistical approach is an adaptation of Student’s t-test and is used with two samples having unequal variances. The MDEL for chronic toxicity is exceeded and a violation will be flagged when a chronic toxicity test, analyzed using the TST statistical approach, results in “Fail”. The MDEL for chronic toxicity is set at the IWC for the discharge (1.06% effluent = 1 IWC = 1/minimum initial dilution factor (Dm) = 1/94.6 = 0.0106) and expressed in units of the TST statistical approach (“Pass” or “Fail”). All monitoring for the MDEL for chronic toxicity shall be reported using the IWC effluent concentration and negative control, expressed in units of the TST. The TST hypothesis (see above) is statistically analyzed using the IWC and a negative control. Effluent toxicity tests shall be run using Short-Term Methods for Estimating the Chronic Toxicity of Effluent and Receiving Waters to West Coast Marine Estuarine Organisms (EPA/600/R-95/136, 1995). The San Diego Water Board’s review of reported toxicity test results will include review of concentration-response patterns as appropriate (see section 4.3.5 of the Fact Sheet (Attachment F)). As described in the laboratory audit directives to the San ▇▇▇▇ Creek Water Quality Laboratory from the State Water Board dated August 07, 2014, and from USEPA dated December 24, 2013, the Percent Minimum Significa...
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