Budget and Timeline. This research partnership will commence in April 2016 and will continue for a two-year period. ELRHA and the Strategic Research Partner commit to a review of the partnership every 6 months. For each distinct piece of work a Statement of Work and budget will be agreed between ELRHA and the strategic research partner. The budget will be presented in terms of number of days at a pre- agreed daily rate. For each piece of work payment will be linked to satisfactory completion the milestones and deadlines outlined in the Statement of Works. The partnership will be under the form of a framework agreement. Payment will only be made on the completion of distinct pieces of work, which at this stage we cannot specifically state what they will be. However, ELRHA and the strategic research partner will agree to a minimum commitment of 40 days a year, with a maximum of 40 additional days on a draw-down basis, and with payment upon satisfactory delivery of work. For ad-hoc project work requests, the partner will respond to ELRHA within three days to confirm their availability and statement of works and, for larger tasks, to respond within a period of 7-day period. As part of the initial work request, ELRHA and the research partner will agree on a timely and reasonable start-date for the work. Subject to the production of relevant receipts and the terms of Save the Children UK’s expenses policy, Save the Children UK will reimburse the cost of reasonable travel, accommodation and out-of-pocket expenses reasonably incurred by the Supplier in the course of providing the Services to Save the Children UK, provided the expenses are agreed in advance by Save the Children UK.
Budget and Timeline. We have outlined the anticipated budget for this study in the appended pricing sheet. We will carry out the study in three phases:
Budget and Timeline. The project will consist of three phases, and will be completed in its entirety by December 31, 2019. Phase I: Design and Permitting The phase will include environmental review and pre-project monitoring. The expected cost is $118,550. Phase II: Restore Site #1 The phase is the restoration of Site #1, as a demonstration project. The expected cost is $115,530. Phase III: Restore Site #2 Under Phase III, Site 2 will be restored. The expected cost is $128,340. Deliverables: The DFW will submit quarterly reports to the Central Valley Water Board until completion of the SEP. Quarterly monitoring reports will be due on the 15th of April, July, October, and February and will describe the progress of each SEP phase and monies expended. The first quarterly report will be due on 15 October 2017. The February 2020 quarterly report will also serve as the final report and shall include a Certification of Completion. The Certificate shall be submitted under penalty of perjury and shall include the following:
Budget and Timeline. Reagent quality for LC-MS must be stringent due to the sensitivity of this technique will be billed to Ampio as a pass-through cost. Further, the costs associated with proteomics and metabolomics center on the type ofreagents necessary to answer the research question. For example, proteins or metabolites that have been labeled with heavy atoms are used for standards when quantifying specific proteins/metabolites. However, for semi-quantification, it is not necessary to have a heavy standard, so it depends on where the initial results lead Ampio. Running LC-MS, processing the data, and interpreting results will require significant time from a highly trained TR scientist. As the TR Omics group will be processing samples handed off from other arms of the research group, the timeline will be impacted by the receipt of samples. Once samples are in hand, sample prep for proteomics generally takes 2 days. Metabolomics sample prep can be done and analyzed in one day. Proteomics LC-MS run time is 3 hours per sample. Metabolomics run time is 10-30 minutes per sample. Once these data are obtained, processing, analyses, report writing, and figure generation will be delivered within 4-6 weeks of the completed experiment. The Omics team will deliver protein and metabolite identification reports, corresponding raw data, and team-guided figures to aid visualization of report results, which will be summerzied in a research report. These data will help guide the research team in several ways: 1) elucidate proteins and metabolites that are differentially regulated in chondrocyte biology downstream of Ampion treatment, 2) uncover protein and metabolic pathways that are regulated by or changing with Ampion treatment in chondrocytes and other cells associated with joint inflammation, 3) identify possible targets for future drug development, and 4) understanding how Ampion is affecting the proteome and influencing cellular metabolism .
Budget and Timeline. Bioinformatics analysis of the effect of Ampion on transcription in immunostimulated PBMCs is currently underway. The manuscript entitled "LMWF5A (Ampion) Demonstrates an Anti-Inflammatory Mode of Action and Similar Drug Targets to Dexamethasone in Activated PBMC" is under peer review at Molecular Biology Reports. These data will also be used to draw connections between Ampion and chondrogenesis. Direct analysis of omics data from inflammasome and chondrocyte experiments will be dependent on timing of raw data receipt. Depending on the level of processing of raw data per each experiment, final upload into IPA may take up to 3-4 weeks for a part-time scientist. Full IPA analysis is an ongoing process depending on what data show and the areas of interest that arise. Analysis and manuscript completion may take up to 3-6 months for a part-time scientist. Research report(s) will be delivered within 4-6 weeks of completed work, and a full report summarizing all work will be presented quarterly. Dataset analyses will be deposited to the M drive server at Ampio Pharmaceuticals. The format will be a research report and include all files that are required to repeat the analyses. These files may include but are not limited to original data, programming scripts, IPA summaries, and graphs of interest. Results and findings that are determined to contribute to the drug development of Ampion will be written into manuscripts and submitted to peer-reviewed journals with Sponsor approval. Upon receipt ofreviewed manuscripts, TR will address, if necessary, reviewer's comments and revise the manuscripts.
Budget and Timeline. Set forth on Schedule III is a true, correct and complete copy of the most recent budget and timeline provided by Dos Caminos to NEP DC Holdings with respect to the Dos Caminos Expansion Projects as of the Signing Date.
Budget and Timeline. Xxxxxxx works on time and materials basis and will accomplish the work as identified in each task. The work under Tasks 1-5 will require some flexibility in the proposed budget with the anticipated annual budget estimated at approximately $100,000 per year for each year during the five-year duration of the contract, with an NTE of $500,000. Notice to Proceed (Notice) for Tasks 1-5 is expected no later than July 1, 2024. Project tasks will immediately commence at the direction of City Staff at that time. All timelines associated with project deliverable reporting are identified in each associated task. Task 6 will be only become available with a written notice to proceed issued by the City with an accompanying task order and budget. Budget considerations for Task 6 are not included in the overall budget proposal for tasks 1-5 since specific tasks have not yet been identified. Contract duration will be for a period of three years with an option to renew for two additional years through June 30, 2029. Project check-in between Zanjero and City Staff will occur no less than twice per month for the duration of the Project.
Budget and Timeline. A. Provide a detailed budget breakdown for the proposed services, including all associated costs per the RFP and hourly rates.
