Table 2a. Species-Specific Planning Survey Requirements Triggered by Land Cover Types and Habitat Elements in the project area based on Chapter 6 of the Final HCP/NCCP. Land Cover Type in the project area? Species Habitat Element in the project area? Planning Survey Requirement Grasslands, oak savanna, agriculture, ruderal San Xxxxxxx kit xxx Assumed if within modeled range of species Identify and map potential breeding and xxxxxxx habitat and potential dens if within modeled range of species (see Appendix D of HCP/NCCP). Western burrowing owl Assumed Identify and map potential breeding habitat. California Possible over summer Identify potential breeding Land Cover Type in the project area? Species tiger salamander California Red-legged Frog Habitat Element in the project area? habitat in proposed project location. Possible over-summer habitat in proposed project location. Planning Survey Requirement habitat Identify potential breeding habitat Aquatic (ponds, wetlands, streams, slough, channels, & marshes) Seasonal wetlands Giant garter snake California tiger salamander California red-legged frog Covered shrimp Aquatic habitat accessible from San Joaquin River Ponds and wetlands in grassland, oak savanna, oak woodland Vernal pools Reservoirs Small lakes Slow-moving streams, ponds, and wetlands Vernal pools Sandstone rock outcrops Sandstone depressions Identify and map potential habitat. Identify and map potential breeding habitat. Document habitat quality and features. Provide Implementing Entity with photo-documentation and report. Identify and map potential breeding habitat. Document habitat quality and features. Provide Implementing Entity with photo-documentation and report. Identify and map potential breeding habitat. Any Xxxxxxxx’x big-eared xxx Xxxxxxxx’x hawk Golden eagle Rock formations with caves Mines Abandoned buildings outside urban areas Potential nest sites (trees within species’ range usually below 200’) Potential nest sites (secluded cliffs with overhanging ledges; large trees) Map and document potential breeding or roosting habitat. Inspect large trees for presence of nest sites. Document and map potential nests.

Table 2a. Sample characteristics Pre-Assessment N (%) Post-Assessment 1 N (%) Post-Assessment 2 N (%) Gender Girl 713 (51.3%) 1,231 (50.8%) 1,097 (50.5%) Boy 677 (48.7%) 1,193 (49.2%) 1,074 (49.5%) Spoken language Dutch 1,170 (84.2%) 2,110 (87.0%) 1,877 (86.5%) Other 220 (15.8%) 314 (13.0%) 294 (13.5%) Pocket money Yes 1,115 (80.2%) 1,889 (77.9%) 1,698 (78.2%) No 275 (19.8%) 535 (22.1%) 473 (21.8%) Money from doing chores Yes 867 (62.4%) 1,544 (63.7%) 1,444 (66.5%) No Talking about money at home Yes 523 (37.6%) 1,095 (78.8%) 880 (36.3%) 1,937 (79.9%) 727 (33.5%) 1,802 (83.0%) No Talking about money in class Yes 295 (21.2%) 792 (57.0%) 487 (20.1%) 1,714 (70.7%) 369 (17.0%) 1,788 (82.4%) No 598 (43.0%) 710 (29.3%) 383 (17.6%) All primary schools in the Netherlands were classified according to their four-digit postal code (without the two uppercase letters). Each postal code area (with approximately 4,000 citizens) was linked to an area-level socioeconomic status score7 from the Sociaal en Cultureel Planbureau [The Netherlands Institute for Social Research] (2018) according to its inhabitants‘ income level, education level, and occupation. The primary schools were then grouped into low, medium, and high socioeconomic status scores (see Table 2B). In each of the three socioeconomic status groups, the Education Research Department of the Executive Agency (Dienst Uitvoering Onderwijs or DUO)8 of the Dutch Ministry of Education, Culture, and Science recruited fifth grade teachers through a simple random sample selection procedure. These teachers were then asked whether or not they used the financial education program. Based on their responses, the schools were divided into two groups. The schools 7The socioeconomic status score used was for 2014 because this indicator is derived every four years by the Netherlands Institute for Social Research. 8DUO Education Research specializes in research for schools in primary and secondary education and secondary vocational education. that used the program served as the intervention group and the schools that did not use the program served as the control group.

Table 2a. Univariate Xxxxxxxx Correlation between Continuous Variables and Total Expenditures within Each County Total Expenditure vs. Variable County A (N=98) County B (N=59) r p-value r p-value Income during year before diagnosis (Xxxx) -0.15096 0.1399 -0.06171 0.6424 Income during year of diagnosis (Yuan) -0.19451 0.0562 -0.03398 0.7983 Difference of incomes before and during diagnosis (Yuan) 0.00797 0.9382 -0.08124 0.5407 Age (years) -0.12082 0.2385 0.16458 0.2129 Distance (km) 0.24661 0.0149 -0.13837 0.2960 Average number of days relatives accompanied patient during hospitalization 0.35890 0.0003 0.18982 0.1535 Average number of visits to TB clinic in one month -0.02052 0.8452 0.11557 0.3877 Cost of transportation from home to TB clinic (Yuan) 0.26661 0.0086 -0.18653 0.1572 Lodging fees (Yuan) 0.75915 <0.0001 0.82617 <0.0001 Examination fee (Yuan) 0.86260 <0.0001 0.80199 <0.0001 B Ultra fee (Yuan) 0.35110 0.0004 0.23494 0.0733 CXR fee (Yuan) 0.59503 <0.0001 -0.04097 0.7580 Chinese medicine fee (Yuan) 0.45437 <0.0001 0.28219 0.0304 Drug fee (Yuan) 0.94189 <0.0001 0.85564 <0.0001 Laboratory fee (Yuan) 0.88779 <0.0001 0.79642 <0.0001 Injection fee (Yuan) 0.94567 <0.0001 0.88118 <0.0001 Oxygen fee (Yuan) 0.46428 <0.0001 0.29231 0.0247 Nursing fee (Yuan) 0.80832 <0.0001 0.76092 <0.0001 Materials fee (Xxxx) 0.78373 <0.0001 0.75465 <0.0001 Treatment fee (Xxxx) --- --- 0.74823 <0.0001 ECG fee (Yuan)** --- --- 0.23864 0.0687 Operation fee (Yuan)** --- --- 0.40127 0.0016 Other fee (Xxxx)** --- --- 0.13188 0.3194 Test fee (Yuan)** --- --- 0.11603 0.3815 Color B Ultra fee (Yuan)** --- --- 0.24828 0.0579 CT fee (Yuan)** --- --- 0.54806 <0.0001 Blood fee (Xxxx)** --- --- 0.31463 0.0152 Ambulance fee (Yuan)** --- --- -0.14761 0.2646 Encephalogram fee (Xxxx)** --- --- -0.13108 0.3224 MRI fee (Xxxx)** --- --- 0.12100 0.3613 County A In County A, the variables that are statistically significantly correlated with total expenditures included distance (r=0.24661, p=0.0149), number of days relatives accompanied patient (r=0.35890, p=0.0003), cost of transportation (r=0.26661, p=0.0086), lodging fee (r=0.75915, p<0.0001), examination fee (r=0.86260, p<0.0001), B ultra fee (r=0.35110, p=0.0004), CXR fee (r=0.59503, p<0.0001), Chinese medicine fee (r=0.45437, p<0.0001), drug fee (r=0.94189, p<0.0001), laboratory fee (r=0.88779, p<0.0001), injection fee (r=0.94567, p<0.0001), oxygen fee (r=0.46428, p<0.0001), nursing fee (r=0.80832, p<0.0001), materials fee (r=0.78373, p<0.0001). These ...

Table 2a. 2021 HEPPP, RLP and ELP funding Program 2021 HEPPP $1,873,057 RLP $8,371,844 ELP $1,947,492 Allocation of places for the purposes of the ELP For the purposes of section 1.61.1 of Division 5 of Part 3 of Chapter 1 of the Other Grants Guidelines (Education) 2012, the number of Commonwealth supported places allocated to the Provider for 2021- 2023 is 564.0.

Table 2a. Genre 1, “Expressed Needs”: Domains, Categories, and Themes Domain Category Theme Frequency(N) Physical/ Cognitive Symptom Management Physical, Occupational, & Respiratory Therapy 7 Medical & Assistive Devices 8 Weight & Nutrition Management 4 Pain Management 2 Pseudobulbar Affect Management 2 Personal Care Assistance with Dressing 4 Assistance with Personal Hygiene/Bathing 5 Assistance with Eating 2 Assistance with Toileting 1 Mobility Assistance Moving Around the Home 2 Transportation Assistance 3 Wheelchair Accessibility 2 Psychosocial Psychological Wellbeing Control Over or Intention to Improve Symptoms 5 Being Realistic/Accepting Disease 4 Hope for Cure 4 Opportunities to Participate in Research 5 Altruistic Actions 5 Positive Outlook/Humor 7 Making the Most Out of It 8 Dealing with Fear & Uncertainty 6 Dealing with Sadness & Depression 8 Planning for End of Life 2 Relationships Love & Support from Family 10 Assistance & Support from Friends 7 Support from ALS Community 5 Spiritual Benefit from Faith Support from Faith Community 8 Trust in Faith Practice for Positive Outcome 6 Spiritual Support Addressing Issues of Theodicy and the Question, “Why me?” 5 Addressing Loss of Faith 1 Management of Care & Information Information Honesty from Provider 2 Value of Information About Disease & Care 8 Interventions & Assistance Preventive Interventions 3 Assistance with Using Medical Devices 2 Access & Quality Concerns About Cost of Care 2 Concerns About Wasting Time & Money On Therapies 2 Desire for More Individualized Care 2 Additional Care Desired Home Care Increased Access to Home Health or Supportive Care 4 Increased Information about Home Health Care & Access 2 Experimental/ Unproven Therapy Complimentary and Alternative Medicine 5 Stem Cell Therapy 1 Medical Marijuana 1 Dietary Supplements 3

Table 2a. Binary Logistic Regression for the Association Between Psychological Distress and Colorectal Cancer Screening in an Age-‐Eligible Population Based Sample (n=1,735), continued Characteristics Adjusted OR 95% CI Demographics Age (cont.) *1.06 1.03, 1.10 Gender Male (ref.) 1.00 Female 0.98 0.64, 1.49 Race/Ethnicity Non Hispanic White 1.00 Hispanic 1.24 0.68, 2.28 Non Hispanic Black *1.98 1.11, 3.54 Non Hispanic Other 1.26 0.57, 2.78 Education Less than High School 1.00 High School Graduate 0.79 0.33, 1.90 Some College 1.05 0.51, 2.20 College Graduate or More 1.21 0.51, 2.86 Household Income Less than $20,000 1.00 $20,000 to <$50,000 *2.55 1.30, 4.97 $50,000 to <$75,000 *3.25 1.39, 7.60 $75,000 or More *7.80 2.99, 20.33 Occupation Employed 1.00 Unemployed 1.56 0.64, 3.79 Other (retired, disabled, homemaker, student, other) *1.98 1.14, 3.45 Marital Status Single, never married 1.00 Married or living as married 0.68 0.29, 1.59 Divorced or Separated 1.14 0.47, 2.79 Widowed 0.29 0.10, 0.83 Note. OR: odds ratio; CI: confidence interval *p<0.05

Table 2a. Development Milestone Events for the GSK-5 Program Milestone Payment [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***]* [***] [***]* [***] Total Development Milestone Payments for the GSK-5 Program [***] *[***]. For avoidance of doubt, except as expressly amended by this Amendment No. 4, the terms and conditions of Section 5.5.2 of the Agreement continue to apply to the GSK-5 Program. Isis understands and acknowledges that, as of the Amendment No. 4 Effective Date, [***].

Table 2a. For Products directed against Initial Collaboration Targets, Additional Targets and Substitute Targets of the Initial Collaboration Targets Base Royalty Rate Portion of Total Annual Net Sales in the Territory (Determined Separately for Each Product) [***] Up to and equal to $1 billion; [***] Greater than $1 billion and less than or equal to $2 billion; [***] Greater than $2 billion and less than or equal to $3 billion; [***] Greater than $3 billion and less than or equal to $4 billion; [***] Greater than $4 billion and less than or equal to $5 billion; [***] Greater than $5 billion. [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Table 2b: For Products directed against Extension Targets and Substitute Targets of the Extension Targets Base Royalty Rate Portion of Total Annual Net Sales in the Territory (Determined Separately for Each Product) [***] [***] [***] [***] [***] [***] [***] [***] For clarity, the Net Sales thresholds in the tables above shall be determined on a Product-by-Product basis. By way of example, if the total annual Net Sales of a Product targeting an Initial Collaboration Target in the Territory in a particular Calendar Year are $2.8 billion, the amount of royalties payable hereunder shall be calculated as follows (subject to any applicable reductions under this Section 8.5): ([***]% x $1 billion) + ([***]% x $1 billion) + ([***]% x $800 million) = $[***] million. Notwithstanding the foregoing, subject to the last sentence of clause 8.5(f) below, in each country where there is no Valid Claim of the Product Specific Patents or CytomX Patent Rights that would be infringed by the sale of such Product in such country absent a license with respect to such Product Specific Patents or CytomX Patent Right under this Agreement, then the Base Royalty Rate (subject to any offsets or reductions set forth below in this Section 8.5) as applied to the sale of such Product in each such country shall be reduced by fifty percent (50%) (i.e., the Base Royalty Rate shall be ½ the rates set forth above in Table 2a or 2b, as applicable, above).

Table 2a. Allocation of Commonwealth supported places for designated higher education courses for 2021 Number of undergraduate medical places (EFTSL) Number of postgraduate medical places (EFTSL) Total number of Commonwealth supported places (EFTSL) Total CGS funding for designated higher education courses Total 0 638 638 $17,226,000 Table 2b: Allocation of Commonwealth supported places for designated higher education courses for 2022 Number of undergraduate medical places (EFTSL) Number of postgraduate medical places (EFTSL) Total number of Commonwealth supported places (EFTSL) Total CGS funding for designated higher education courses Total 0 636 636 $17,566,956 Table 2c: Allocation of Commonwealth supported places for designated higher education courses for 2023 Number of undergraduate medical places (EFTSL) Number of postgraduate medical places (EFTSL) Total number of Commonwealth supported places (EFTSL) Total CGS funding for designated higher education courses Total 0 634 634 $17,914,304 Appendix 3 Indigenous, Regional and Low Socio-Economic Status Attainment Fund In 2021, the Indigenous, Regional and Low Socio-Economic Status Attainment Fund (IRLSAF) consists of five components: Higher Education Participation and Partnerships Program (HEPPP); National Priorities Pool Program; Regional Partnerships Project Pool Program; Regional Loading Program (RLP); and Enabling Loading Program (ELP); IRLSAF funding Grant amounts for the HEPPP, RLP and ELP in 2021-2023 are calculated using the method specified for the relevant component in Divisions 1, 4 and 5 of Part 3 of Chapter 1 of the Higher Education Support (Other Grants) Guidelines 2022 (see paragraph 41-30(a) of the Act) and are estimated in Table 3a below.

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