APC Sample Clauses
APC. Inactivation of the Adenomatous Polyposis Coli gene (APC) on chromosome 5q has been shown to be the underlying defect in familial adenomatous polyposis (FAP), in which germline mutations in APC are found. However, inactivation of APC is also one of the earliest events in the development of sporadic colorectal cancers with somatic mutations in the mutation cluster region (MCR).131,132 In the majority of colorectal neoplasia, the APC gene is either deleted or mutationally inactivated by the introduction of premature termination codons. This inactivation is already observed in the smallest precursor lesions of adenomas, the dysplastic aberrant crypt foci132,133 and therefore, APC is called the “gatekeeper” of colorectal epithelial cell proliferation, as its inactivation is a rate-limiting event in the initiation of the adenoma-carcinoma sequence. APC has 3 binding sites which allows for interaction with ß-catenin, a well-known adhesion and signaling molecule which is associated with E-cadherin in the formation of epithelial cell-cell contacts. By the interaction with ß-catenin, APC is a key member of the Wnt signal transduction pathway (Figure 1), which is recognised to function in critical biological processes such as embryonic induction, the generation of cell polarity and the specification of cell fate.134 In general, secreted Wnt/Wingless glycoproteins interact with receptors of the frizzled gene family, thereby activating the cytoplasmatic phosphoprotein dishevelled (dsh). Dsh inhibits the function of the serine/threonine kinase GSK3β. Inhibition of GSK3β results in the accumulation of β-catenin in the cytoplasm and in its translocation to the nucleus where it forms complexes with the TcF/Lef family of HMG transcription factors.135 These complexes can activate target genes, of which c-myc136 and cyclin D1137 are examples. In the absence of the Wnt signal, GSK3β forms a complex together with conductin, axin, APC and β-catenin promoting the rapid degradation of β-catenin.138 Hence, loss of APC results in a critical loss over β-catenin control, leading to constitutive signaling to the nucleus and activation of downstream target genes. E- c ad h erin F r izzled (rec ep to r ) -ca t DS H GS K 3β Deg ra d e d -ca t C AP W n t- 1 -ca t -ca t -ca t Tcf-4 Targ et g en es nu c le u s
APC. The parties hereby agree that APC shall, if formed as a wholly owned subsidiary of ATLS within two business days of the date of this agreement, be deemed to be the Assignee hereunder for all purposes as if it had been party from the original execution time of this Agreement; provided that ATLS shall remain jointly and severally liable for, and shall guarantee payment and performance of, all obligations of APC pursuant to this Agreement.
APC. A los efectos de la Sección 6 de los Términos y Condiciones Generales, las referencias al Coste de Licencia se entenderán referidas a las Tarifas bajo los presentes Términos del Producto.
APC. Article processing charge; a fee payable in order for an article to be published as an Open Access Article.
APC. APC shall cause AMH to perform all of its obligations relating to this Agreement and the transactions contemplated hereby. [Signature page follows]
APC. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of total meat consumption was estimated to be 18.8% lower (p=0.12) in whole crypts and 22.7% lower (p=0.14) in the lower 60% of crypts. Similarly the mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of saturated fat consumption was estimated to be 14.2% lower (p=0.18) in whole crypts and 18.8% lower (p=0.19) in the lower 60% of crypts. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of total fat consumption was estimated to be 17.8% lower (p=0.19) in the lower 60% of crypts. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of vegetable and fruit consumption was also estimated to be 22.0% lower (p=0.20) in the lower 60% of crypts, although the direction of this association was opposite to that hypothesized. The estimated associations of the following participant characteristics with APC did not meet our criteria outlined in the statistical analysis section for inclusion in Table 2: age, aspirin use, other NSAID use, smoking, physical activity, BMI, serum 25-OH vitamin D concentrations, total vitamin E intake, total calcium intake, and dietary fiber intake.
APC. Consultant and its sub-consultants will permit access to all records of employment, employment advertisements, application forms, and other pertinent data and records by the State Fair Employment Practices and Housing Commission or any other agency of the State of California designated by State to investigate compliance with this section. because of race, color, age, creed, sex, or national origin. Such action shall include, but not be limited to, employment, upgrading, demotion or transfer, recruitment, or recruitment advertising, layoff or termination, rates of pay or other forms of compensation and selection for training, including apprenticeship. Cost Principles. APC, Consultant and its sub-consultants will be obligated to agree, that (a) Contract Cost Principles and Procedures, 48 CFR, Federal Acquisition Regulations System, Chapter 1, Part 31, et seq., shall be used to determine the allowability of individual Project cost items and (b) all parties shall comply with Federal administrative procedures in accordance with Title 2, CFR, Part 200, Uniform Administrative Requirements, Cost Administrative Requirements for Federal Awards, and 49 CFR, Part 18, Uniform Administrative Requirements for Grants and Cooperative Agreements to State and Local Governments, as applicable. For more information, refer to: xxxx://xxx.xxxxxxxxx.xxx/nara/index.html.
APC. The term "APC" shall mean ALLIED Property and Casualty Insurance Company, an Iowa stock insurance company.
APC. All Purpose Clerks (APC) are employees who may be assigned to any work performed by the former positions falling under the following classifications: non-food clerk, food clerk, service deli clerk, wall deli, produce clerk, bakery sales, and click list employees, and including all positions associated with these classifications, such as service booth, front end, floral, nutrition, etc.. The provisions of this Article apply only to these employees. Recognizing that work is currently performed in various departments as established by Xxxxx’x (and that Xxxxx’x may remove or add departments in the future providing prior notice to the Union of such changes), it is agreed that before an employee is regularly scheduled outside their current home department, that they should be qualified to perform the work of that department, as determined by Xxxxx’x. Xxxxx’x retrains the right to train employees and assign work at its discretion. To be considered qualified for work in departments outside an employee’s home department, the employee shall be provided training for such work and must have successfully performed the work of that department (as determined by management). Management retains the right to train employees for departments at its discretion. Notwithstanding, management agrees to allow APCs to sign-up within their store for voluntary training during the first fifteen (15) days of February, to be effective the first workweek in March, and the first fifteen (15) days in August to be effective the first workweek in September. With respect to voluntary training, it is understood and agreed: Management will train at least two (2) employees, by seniority within each store from the voluntary list for each department during each six month period referenced above. Nothing herein prevents the Employer from assigning employees to training based on store or company needs. Employees shall be allowed to bid to another department when a vacancy occurs within their store and provided such employee is of the same status (full-time/part-time) required by the vacancy. If the employees that bid are equally qualified (in management’s judgement), seniority will prevail. In no event shall an employee be allowed to successfully bid more than once in any twelve (12) consecutive calendar month period. Management retains the right to determine the number of full-time and part-time positions in each department and thus may move full-time employees between departments, if deemed necessa...
APC. Alberta Purchasing Connection, an online site created by the government to post opportunities for a transparent process. xxx.xxxxxxxxxxxxxxxxxxxx.xx.