APC. Inactivation of the Adenomatous Polyposis Coli gene (APC) on chromosome 5q has been shown to be the underlying defect in familial adenomatous polyposis (FAP), in which germline mutations in APC are found. However, inactivation of APC is also one of the earliest events in the development of sporadic colorectal cancers with somatic mutations in the mutation cluster region (MCR).131,132 In the majority of colorectal neoplasia, the APC gene is either deleted or mutationally inactivated by the introduction of premature termination codons. This inactivation is already observed in the smallest precursor lesions of adenomas, the dysplastic aberrant crypt foci132,133 and therefore, APC is called the “gatekeeper” of colorectal epithelial cell proliferation, as its inactivation is a rate-limiting event in the initiation of the adenoma-carcinoma sequence. APC has 3 binding sites which allows for interaction with ß-catenin, a well-known adhesion and signaling molecule which is associated with E-cadherin in the formation of epithelial cell-cell contacts. By the interaction with ß-catenin, APC is a key member of the Wnt signal transduction pathway (Figure 1), which is recognised to function in critical biological processes such as embryonic induction, the generation of cell polarity and the specification of cell fate.134 In general, secreted Wnt/Wingless glycoproteins interact with receptors of the frizzled gene family, thereby activating the cytoplasmatic phosphoprotein dishevelled (dsh). Dsh inhibits the function of the serine/threonine kinase GSK3β. Inhibition of GSK3β results in the accumulation of β-catenin in the cytoplasm and in its translocation to the nucleus where it forms complexes with the TcF/Lef family of HMG transcription factors.135 These complexes can activate target genes, of which c-myc136 and cyclin D1137 are examples. In the absence of the Wnt signal, GSK3β forms a complex together with conductin, axin, APC and β-catenin promoting the rapid degradation of β-catenin.138 Hence, loss of APC results in a critical loss over β-catenin control, leading to constitutive signaling to the nucleus and activation of downstream target genes. E- c ad h erin F r izzled (rec ep to r ) -ca t DS H GS K 3β Deg ra d e d -ca t C AP W n t- 1 -ca t -ca t -ca t Tcf-4 Targ et g en es nu c le u s
APC. The parties hereby agree that APC shall, if formed as a wholly owned subsidiary of ATLS within two business days of the date of this agreement, be deemed to be the Assignee hereunder for all purposes as if it had been party from the original execution time of this Agreement; provided that ATLS shall remain jointly and severally liable for, and shall guarantee payment and performance of, all obligations of APC pursuant to this Agreement.
APC. The term "APC" shall mean ALLIED Property and Casualty Insurance Company, an Iowa stock insurance company.
APC. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of total meat consumption was estimated to be 18.8% lower (p=0.12) in whole crypts and 22.7% lower (p=0.14) in the lower 60% of crypts. Similarly the mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of saturated fat consumption was estimated to be 14.2% lower (p=0.18) in whole crypts and 18.8% lower (p=0.19) in the lower 60% of crypts. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of total fat consumption was estimated to be 17.8% lower (p=0.19) in the lower 60% of crypts. The mean adjusted APC expression among participants in the highest relative to those in the lowest tertile of vegetable and fruit consumption was also estimated to be 22.0% lower (p=0.20) in the lower 60% of crypts, although the direction of this association was opposite to that hypothesized. The estimated associations of the following participant characteristics with APC did not meet our criteria outlined in the statistical analysis section for inclusion in Table 2: age, aspirin use, other NSAID use, smoking, physical activity, BMI, serum 25-OH vitamin D concentrations, total vitamin E intake, total calcium intake, and dietary fiber intake.
APC. Unless the context otherwise requires, the term "APC" includes Alabama Power Company, its directors, officers, employees, agents, successors and permitted assigns.
APC. Article processing charge; a fee payable in order for an article to be published as an Open Access Article.
APC. The APC experience sharing workshop was an excellent introduction by the APC panel. Together with the pre-assessment workshops, these workshops have assisted our candidates to pass the APC without lowering the entry level. Special thanks to Xxxxxxx Xxxx, our APC Convenor, and the active panel Divisional Council & Young Surveyors Group Reports Number of candidates passing 3 written assessment in 2006 but without report submitted Passing rate of oral assessment 46% (enrolment) Passing rate of oral assessment 54% (attempt) Total number of candidates: 122 (enrolled); 112 (attended) Number of candidates passing 37 the oral assessment Overall passing rate 30.3 % (enrolled) 33 % (attended) members such as Xxxxx Xxxx, Xxxxxxxx Xxxx and various panel members who have spent a lot of time to prepare the APC and arranging the workshops. Written Assessment 2007 was finished in October and results are expected to be available in late November. The summary of the Assessment for the year 2006 is as follows: Written Assessment 2006 The results of the APC written assessment held on 12 October 2006 are as follows:
APC. Consultant and its sub-consultants shall ensure that the evaluation and treatment of their employees and applicants for employment are free from such discrimination and harassment. APC, Consultant and its sub-consultants shall comply with the provisions of the Fair Employment and Housing Act (Government Code, Section 12900 et seq.) and the applicable regulations promulgated thereunder (California Code of Regulations, Title 2, Section 7285.0 et seq.). The applicable regulations of the Fair Employment and Housing Commission implementing Government Code Section 12990 (a-f), set forth in Chapter 5 of Division 4 of Title 2 of the California Code of Regulations are incorporated into this Agreement by reference and made part hereof as if set forth in full.
APC. Consultant and its sub-consultants will permit access to all records of employment, employment advertisements, application forms, and other pertinent data and records by the State Fair Employment Practices and Housing Commission or any other agency of the State of California designated by State to investigate compliance with this section. because of race, color, age, creed, sex, or national origin. Such action shall include, but not be limited to, employment, upgrading, demotion or transfer, recruitment, or recruitment advertising, layoff or termination, rates of pay or other forms of compensation and selection for training, including apprenticeship. Cost Principles. APC, Consultant and its sub-consultants will be obligated to agree, that (a) Contract Cost Principles and Procedures, 48 CFR, Federal Acquisition Regulations System, Chapter 1, Part 31, et seq., shall be used to determine the allowability of individual Project cost items and (b) all parties shall comply with Federal administrative procedures in accordance with Title 2, CFR, Part 200, Uniform Administrative Requirements, Cost Administrative Requirements for Federal Awards, and 49 CFR, Part 18, Uniform Administrative Requirements for Grants and Cooperative Agreements to State and Local Governments, as applicable. For more information, refer to: xxxx://xxx.xxxxxxxxx.xxx/nara/index.html.
APC. A los efectos de la Sección 6 de los Términos y Condiciones Generales, las referencias al Coste de Licencia se entenderán referidas a las Tarifas bajo los presentes Términos del Producto.
