S/T methodology and associated work plan. B 1.3.1 Overall strategy and general description
S/T methodology and associated work plan. Overall Strategy of the Work Plan
S/T methodology and associated work plan. 3.1 OVERALL STRATEGY OF THE WORK PLAN NOPTILUS comprises 9 Work-Packages (WP), each consisting of several tasks. The project is organized along 7 technical work packages, one of them dedicated to integration and evaluation, and 2 work packages for management and dissemination, respectively. Each partner takes on one side the responsibility for his research topic, but is also strongly involved in the integration, demonstration and evaluation of the overall system. The common research platform (multi-AUV system) and the integrated demonstrations guarantee a strong interaction and collaboration between the partners. The overall duration of NOPTILUS is scheduled for 4 years (48 months) and is divided in 4 main stages (see Xxxxx chart in Section B1.3.2): Development and design of the individual methodological and algorithmic components and elements addressing the low-level NOPTILUS objectives (i.e. related to communications, sensing, and localization) as well as definition and specification of all hardware components of the NOPTILUS system (WP2 and WP3). Development and design of all methodological and algorithmic components and elements addressing the medium-level NOPTILUS objectives (WP4 and WP5). Development and design of all methodological and algorithmic components and elements addressing the high-level NOPTILUS objectives (WP6 and WP7). Integration, demonstration and evaluation of the overall NOPTILUS system (WP8). Project management and dissemination, training and exploitation activities (WP1 and WP9) constitute a continuous phase that is active during the whole project life. The first 3 of the above stages end with an integration week and are managed along a list of milestones and deliverables. The integration weeks assemble the key project engineers at the Test Case location for 2-3 weeks. The main objective of these meetings is to integrate and test all elements, track progress, identify and resolve potential problems, and define the next phase in more detail. Moreover, these meetings help to integrate the team and their developed technologies, and serve as the main points of reference for the progress of the project. In addition to the integration weeks involving all partners, individual integration will be realized by exchange of PhD students and semester-long visits of individual partners. Furthermore, CERTH will have a technical project manager that will regularly (at least once every year) visit each partner’s lab and discuss all upcoming...
S/T methodology and associated work plan. This section presents the work plan of the project. It presents the detailed work packages, deliver- xxxxx and milestones and the involvement of the different partners.
1.3.1 Overall strategy of the work plan
S/T methodology and associated work plan. Joint Programme of Activities (JPA)
S/T methodology and associated work plan. Fig. 8 shows the time plan and the overall strategy of the ASC-Inclusion project.
S/T methodology and associated work plan. 1.3.1.1 Overall strategy and general description of the workplan Subproject 1 (SP1) will define the genetic aberrations in ETs and how they relate to clinical phenotypes and impinge on the proteome. To this end will derive global network topologies for gene regulatory networks (GRNs) by data-driven modelling and Bayesian inference mainly using mRNA, xxXXX transcriptome profiles and ChIP- chip/seq data from EETP. SP2 will focus on generating data that connect GRNs with cytosolic signalling networks by performing (i) quantitative proteomics experiments on transcription factor (TF) interactions with DNA and proteins; (ii) global phosphoproteomics of TF upstream pathways; (iii) chemical proteomics on a panel of 10 kinase SP3 will develop the mechanistic kinetic models of critical subnetworks based on (i) quantitation of protein network components; (ii) known ET TF oncogene modules (Myc, EWS-FLI1) and as informed by the perturbation and proteomics experiments. These models will be used to identify emergent functional network properties and fragile nodes that can be targeted by drugs, siRNAs and combinations thereof. SP4 will perform validation of the mathematical model predictions in biological models comprising (i) ET cell lines with tunable oncogene expression; (ii) preclinical ET xenograft models; and (iii) clinical specimens. SP5 will establish a datawarehouse to (i) store and manage all ASSET data; (ii) link the data to enable zooming between different resolution models; (iii) enable advanced data analysis and interpretation on a semantic meta- level; and (iv) ensure that the data can be made available to the scientific community. Standardisation of data generation. In order to guarantee consistency and comparability of the data generated in ASSET we will (i) use a defined panel of core cell lines representing the three ET entities: UW-228 (MB) with tet-regulatable c-Myc; A673 (ESFT) with tet-regulatable EWS-FLI1; SH-SY5Y (NB) with differentially regulatable TrkA and N-Myc; and for the ALK work, SK-N-AS (NB) with regulated expression of the ALK F1174L mutant. The core cell line panel will be exome sequenced and all partners will work with the same cells; (ii) establish standard operating procedures (SOPs) for handling the cell lines and experimental measurements; and (iii) establish a short-term exchange programme through which wet and dry researchers will visit partner labs to ensure that data generation and modelling work is pursued according to agreed s...
S/T methodology and associated work plan. The NFFA Design Study will perform the activities described in five work packages (WPs) with the aim of developing a clear mission, a feasible structure, and a scheme of implementation of the new European Research Infrastructure.
a) definition of the mission of NFFA as European RI and of its Centres, analysis of the multidisciplinary users communities and of the access policy, analysis of all the existing national activities in nanoscience that could usefully converge in participating/supporting NFFA-RI Centres.
b) definition of the specifications of the general structure of the Centres, which will define the NFFA standard. This includes technical work in the development of novel schemes of technical infrastructure (definition of user accessible clean rooms) with built-in flexibility, of instrumentation for nanofabrication and for characterization of materials and systems, of methods of analysis including computation.
c) definition of specialised NFFA Centres and of the users communities that would take maximum benefits from their existence.
d) analysis of the existing LSFs in terms of the best synergies that could be developed with NFFA and definition of a possible roadmap for the RI.
e) definition of schemes for the future training activities at NFFA-RI Centres. Definition of the specifications of a NFFA-RI data repository and its rules of access. Dissemination of the NFFA concept via web site, public workshops and NFFA book. The method that will be followed is to cover the points a-e by actions described in specific work packages that will be co-ordinated by the initial partners of NFFA-Design Study who will aim, during the first year of the Design Study, to reach a full European dimension of the project, also by seeking the direct involvement of more partners who are not in the proposers’ list. Explicit interest in NFFA-Design Study has been expressed by institutions who declare to consider joining NFFA- Design Study after start. This is an important goal of NFFA-Design Study. The initial partners do provide a wide coverage of competences and do represent a relevant part of the future European users community, but by far not all of it, nor most of it. It is nevertheless very appropriate that the starting group is of adequate size to draft the Design Study while reaching out to all relevant LSFs and nanoscience institutions that are needed for a full assessment of NFFA-Design Study objectives. A series of targeted and widely advertised workshops will gu...
S/T methodology and associated work plan. B.1.3.1 Overall strategy and general description The project objectives will be implemented according to the following work plan. The project’s S&T achievements will be guided by WP1 where the application scenarios will be defined in detail, as well as the collection of data sets and their annotation. The scientific and method- ological foundations will be developed in four workpackages: WP2, WP3, WP4, and WP5, along the objectives defined by WP1. The outcomes of these workpackages will be twofold:
(i) New methods and algorithms for audio-visual humanoid robots and (ii) software packages implementing these algorithms and which will be make publicly available on a open-source software (OSS) platform. The development of the OSS platform itself will be carried out in WP6. The platform will integrate software from all partners. WP6 will use software engineering tools in order to facilitate the integration: maintenance of source code, changes and versions track, percentage of author contribution for each source module, associated documentation, etc. The setup and maintenance of this OSS platform will be key to successful integration between the methods developed in WP2-WP5 and their implementation onto a programmable robot (WP7). Technology (hardware-software) integration, hardware development, and proof- of-concept demonstrators will be achieved in WP7: HUMAVIPS S&T findings will be carefully implemented onto the NAO humanoid robot within the framework of the NaoQi architecture. NaoQi provides an interface between the developed software modules and the robot hardware. Hence the integration will be done gradually and tested accordingly. In parallel, WP8 will ensure proper dissemination and exploitation of the project’s outcomes and results. WP9 will implement the project management. The milestones MS3, MS4, MS5, and MS6 will assess the progress accross these workpackages. The timing of the workpackages’ tasks is shown on page 16. The interconnections between the project’s main components are shown on page 17.
B.1.3.2 Timing of workpackages and their components
B.1.3.3 Work package list/overview
S/T methodology and associated work plan. This section describes the proposed work at multiple levels. It begins with a brief overview of how the work is split into different work packages (WPs) and discusses how the various WPs collaborate and integrate toward the overall project objectives. A graphical presentation of the timing and interdependencies of WPs is given. A more detailed description of the work in each WP is then provided.
