Significance. This proposal fits into Intel’s digital health vision where we can extend the PC penetration into the elders' households; therefore creating a new potential market for Intel-based PCs and communication products. In addition, the proposed home-care application is likely to generate high sensor data processing and communication workload, leading to demand for Intel-based PC and communication products upgrades. Home gateway PC runs
Significance. Does the project address an important problem or a critical barrier to progress in the field? Is there a strong scientific premise for the project? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? Does the proposed project have commercial potential to lead to a marketable product, process or service? (In the case of Phase II, Fast-Track, and Phase II Competing Renewals, does the Commercialization Plan demonstrate a high probability of commercialization?) Was the Target Product Profile fully described, in terms of how it will affect clinical practice, existing treatments, and therapeutic development efforts underway in academia and industry. Was the current state of knowledge of the etiology, clinical characteristics, and prevalence of the proposed disease indication adequately described? Are available treatments (if any), their limitations, and how the proposed project would provide an advantage over all existing therapies been adequately described? If the proposed therapy is an improvement over an earlier generation unmarketed agent(s) , has the potential advantages of the new agent been described? Have results from previous clinical trials with related agents been included? Has the relationship of the proposed project to therapy development efforts underway in academia and industry been adequately described? Are the advantages of the new proposed therapy adequately described considering other investigational agents that might be entering the clinical pipeline? Has a Target Product Profile (TPP) based on the FDA guidance showing the ultimate goals of the proposed therapy development effort, such as disease indication and stage, patient population, delivery mode and dosing regimen, treatment duration, and standards for clinical efficacy been provided? Has the rationale behind the minimally acceptable and ideal parameters for the clinical population been adequately discussed? Has the plan for, and feasibility of, the first clinical proof-of-concept study that aligns with the proposed TPP been adequately discussed? In addition, for applications proposing clinical trials Are the scientific rationale and need for a clinical trial to test the proposed hypothesis or intervention well supported by preliminary data, clinica...
Significance. An informed judgement of what is important based on the available evidence. Significance is further defined in the Review Board’s “Reference Bulletin: Operational Interpretation of Key Terminology in Part Five of the Mackenzie Valley Resource Management Act”, available at xxxxxx.xx.xx. Social infrastructure Those community agencies, services, and facilities and other social support measures necessary for adequate functioning of a community, and that contribute to the well-being of its residents. Socio-economic environment
Significance. It is expected to enhance research and innovation cooperation in different fields like Water, Energy, Healthcare, Agritech & Bioeconomy, Integrated Cyber-Physical Systems, Information and Communication Technologies, Nanotechnology, and clean technologies, etc. It will also strengthen the institutional linkages in research, exchange of researchers, students, startups and attract co-investment of resources for co-generation of knowledge.
Significance. The development of a vaccine to prevent AIDS is the best hope for controlling the epidemic that has led to infection of more than 30 million people with the HIV-1 virus worldwide. A vaccine approach that reduces viral load would certainly be beneficial, but one that elicits sterilizing immunity would be preferred. Conventional vaccine approaches based on delivery of HIV-1 envelope (Env) proteins or peptides derived from Env sequences have failed to generate broadly neutralizing antibodies (bNAbs) to the virus, which mutates rapidly to escape from the immune response. Recently, [*] have been discovered from subjects in the [*]. Several of these antibodies, including [*] determinants alone or in the context of the [*] protein. Importantly, these antibodies are even more potent (i.e., they neutralize HIV-1 at lower antibody concentrations) than other newly discovered [*]. Immunogens that elicit antibodies similar to the [*] could be ideal vaccine candidates.
Significance. The results of the study provide insight into the factors that reduce the effectiveness of the partnership between pedagogical universities and schools, helping policy makers and educational managers have appropriate measures to develop the professionalism of teachers in high schools and help pre-service students prepare for future careers.
Significance. A thorough understanding of a historic asset’s significance is the starting point for any sound management plan. Every HPA should include a statement that addresses the collective and individual significance of the assets covered by the agreement. The statement of significance should consider the assets together and identify any collective significance arising, for instance, from shared functions, construction techniques or designs. It should also give brief descriptions of the individual assets in the context of the whole. Focusing on the heritage values of the historic assets will help in the analysis of their significance: evidential value: the extent to which the physical fabric tells how and when an asset was made, how it was used and how it has changed over time historical value: a historic asset may illustrate a particular past way of life or be associated with a specific person or event and there may be physical evidence for these connections which it could be important to retain aesthetic value: the design, construction and craftsmanship of an asset, which can also include the setting and views to and from a historic asset communal value: an historic asset may have particular significance to people for its commemorative, symbolic or spiritual value, or for the part it has played in local cultural or public life. Cadw’s Conservation Principles for the sustainable management of the historic environment in Wales7 provides further information on heritage values. Works The parties to the HPA will have to agree the works that need to be undertaken during the lifetime of the agreement to achieve its objectives. A historic asset’s significance should be a central consideration when formulating any plans. The works should aim to realise the greatest benefit and cause the least harm, so the significance of the asset is sustained or enhanced. If the HPA includes planned works to a listed building that is not a private dwelling, consideration will also need to be given to access issues. The planned works will need to provide reasonable access and have the least detrimental impact on the significance of the listed building. Heritage Impact Assessment in Wales8 provides further information on access issues. An HPA cannot give consent for the demolition of a listed building, the demolition or destruction of a scheduled monument, or tipping on or the flooding of a scheduled monument.9 Every HPA must provide detailed specifications for the works that will ...
Significance. GDM represents a common and serious health care problem in the U.S. and around the world. Increasing evidence from randomized controlled trials (RCT) indicate that lifestyle intervention programs based on promoting good nutrition and physical activity before and early in pregnancy may lower the incidence of GDM (Yin et al., 2014). Some lifestyle intervention studies have reported improvements in risk factors associated with GDM in Caucasian women (Xxxxxx-Xxxxx, 2015); however, the impact of such intervention in Hispanic women has not been investigated. We believe that screening and intervention programs will have a positive impact not only in limiting weight gain during pregnancy, but also in preventing GDM and its complication in overweight/obese Hispanic women.
Significance. Major depression is one of the most common mental disorders in the U.S and the second most common cause of disability-adjusted life years (DALYs) lost from ages 15-44 (SAMHSA, 2017; Xxxxxxx & Xxxxxxxxx, 2015). It causes severe symptoms that affect how one feels and thinks, interfering with their ability to carry out daily activities such as sleeping, eating, working or studying (NIMH, 2016). Some symptoms of depression include persistent sadness or emptiness, feelings of hopelessness or worthlessness, loss of interest in hobbies, decreased energy or fatigue, difficulty concentrating, and difficulty sleeping. Symptoms must be present most of the day, nearly every day for at least 2 weeks in order for someone to be diagnosed with depression (NIMH, 2016). Individuals can have one only episode of depression during their lifetime, however it is more common to have multiple episodes. Depression is most commonly treated with medications or antidepressants, psychotherapy, or a combination of both methods (NIMH, 2016). If left untreated, depression can lead to poor quality of life, which may be evidenced by substance abuse, increased absenteeism, academic or occupational impairment, self-injury or suicide (Xxxxxx, Xxxxxx & Richie, 2014). It is projected that by 2030, depression will be among the top three contributors to burden of disease (Xxxxxxx & Xxxxxx, 2006). In 2016, about 16.2 million adults aged 18 and older (6.7% of all U.S. adults) experienced at least one major depressive episode (MDE) (SAMHSA, 2017). Of this group, nearly two-thirds had an MDE with severe impairment, which means these individuals had difficulty managing at home, managing well at work, maintaining relationships or maintaining a social life (SAMHSA, 2017). Research conducted by the Centers for Disease Control and Prevention revealed that major depressive disorder is more prevalent among women than in men across every age group. It was also found that African-Americans had higher rates of mild, moderate and severe depressive symptoms than whites (NCHS, 2014). African Americans make up approximately 13% of the U.S. population, yet they account for 18.6% of those affected by mental illness (U.S. Census Bureau, 2016; NAMI, 2015). On the 2016 Behavioral Risk Factor Surveillance System Survey, 34.7% of African American adults reported poor mental health status (KFF, 2016). Despite these findings, African-Americans are least likely to receive treatment for depression and other mental illnesses (...
Significance. The proposal identifies a critical need to address the underutilization of mental healthcare by African American women living with depression, and seeks to address this problem in a modern way with the inclusion of a smartphone application to be tailored to the needs of African American women with mental health needs. While I deemed this a xxxxxx proposal supported by peer review research findings, I recommend the following be considered for inclusion in the literature review as well.
